ID   SCAM5_BOVIN             Reviewed;         235 AA.
AC   Q17QF8;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Secretory carrier-associated membrane protein 5;
DE            Short=Secretory carrier membrane protein 5;
GN   Name=SCAMP5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the calcium-dependent exocytosis of signal
CC       sequence-containing cytokines such as CCL5. Probably acts in
CC       cooperation with the SNARE machinery (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via C-terminal part) with SYT1 and SYT2;
CC       interaction with synaptotagmins making a link with the SNARE molecules.
CC       Interacts with SLC9A7 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi
CC       network membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Recycling endosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle,
CC       synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Note=Mainly localizes in Golgi apparatus membrane. Upon
CC       calcium-triggered exocytosis, it translocates to the cell membrane.
CC       Highly enriched in synaptic vesicles (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCAMP family. SCAMP5 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI18387.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC118386; AAI18387.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001160037.1; NM_001166565.1.
DR   AlphaFoldDB; Q17QF8; -.
DR   SMR; Q17QF8; -.
DR   STRING; 9913.ENSBTAP00000054032; -.
DR   PaxDb; Q17QF8; -.
DR   GeneID; 508510; -.
DR   KEGG; bta:508510; -.
DR   CTD; 192683; -.
DR   eggNOG; KOG3088; Eukaryota.
DR   HOGENOM; CLU_066546_1_0_1; -.
DR   InParanoid; Q17QF8; -.
DR   OrthoDB; 995882at2759; -.
DR   TreeFam; TF313797; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0055038; C:recycling endosome membrane; IBA:GO_Central.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032588; C:trans-Golgi network membrane; IBA:GO_Central.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; ISS:UniProtKB.
DR   GO; GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   InterPro; IPR007273; SCAMP.
DR   PANTHER; PTHR10687; PTHR10687; 1.
DR   Pfam; PF04144; SCAMP; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasmic vesicle; Endosome; Exocytosis; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Synapse; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..235
FT                   /note="Secretory carrier-associated membrane protein 5"
FT                   /id="PRO_0000370552"
FT   TOPO_DOM        1..39
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..67
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..102
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..148
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        170..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   235 AA;  26116 MW;  C86DDC86B030B7BB CRC64;
     MSEKVNNFPP LPKFIPLKPC FYQDFEADIP PQHLSMTKRL YYLWMLNSVT LAVNLVGCLA
     WLIGGGGATN FGLAFLWLIL FTPCSYVCWF RPIYKAFKTD SSFSFMAFFF TFMAQLVISI
     IQAVGIPGWG VCGWIATISF FGTNIGSAVV MLIPTVLFTV MAVFSFIALS MVHKFYRGSG
     GSFSKAQEEW TTGAWKNPHV QQAAQNAAMG AAQGAMNQPQ TQYSATPNYT YSNEM