ID   SCAM5_XENTR             Reviewed;         231 AA.
AC   Q28F21; Q66KC1;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Secretory carrier-associated membrane protein 5;
DE            Short=Secretory carrier membrane protein 5;
GN   Name=scamp5; ORFNames=TGas073j15.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the calcium-dependent exocytosis of signal
CC       sequence-containing cytokines. Probably acts in cooperation with the
CC       SNARE machinery (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi
CC       network membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Recycling endosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle,
CC       synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Note=Mainly localizes in Golgi apparatus membrane. Upon
CC       calcium-triggered exocytosis, it translocates to the cell membrane.
CC       Highly enriched in synaptic vesicles (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCAMP family. SCAMP5 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH80466.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CR762215; CAJ83857.1; -; mRNA.
DR   EMBL; BC080466; AAH80466.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001007955.1; NM_001007954.1.
DR   RefSeq; XP_012821918.1; XM_012966464.1.
DR   RefSeq; XP_012821919.1; XM_012966465.2.
DR   AlphaFoldDB; Q28F21; -.
DR   SMR; Q28F21; -.
DR   DNASU; 493330; -.
DR   Ensembl; ENSXETT00000082693; ENSXETP00000075981; ENSXETG00000010669.
DR   GeneID; 493330; -.
DR   KEGG; xtr:493330; -.
DR   CTD; 493330; -.
DR   Xenbase; XB-GENE-22061154; scamp5.1.
DR   InParanoid; Q28F21; -.
DR   OrthoDB; 995882at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000010669; Expressed in brain and 14 other tissues.
DR   ExpressionAtlas; Q28F21; differential.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; ISS:UniProtKB.
DR   GO; GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007273; SCAMP.
DR   PANTHER; PTHR10687; PTHR10687; 1.
DR   Pfam; PF04144; SCAMP; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasmic vesicle; Endosome; Exocytosis; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Synapse; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..231
FT                   /note="Secretory carrier-associated membrane protein 5"
FT                   /id="PRO_0000370557"
FT   TOPO_DOM        1..39
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..67
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..102
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..148
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        170..231
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   231 AA;  25445 MW;  C34421A86DC9F5D0 CRC64;
     MAEKANNFPP LPRFIPLKPC FHQDFENDIP DLHRTTCKRL YSLWMLNSIT LGVNLIGCLA
     WMIGGGGAIN FGLAILWVIL FTPCSYVCWF RPAYKAFKTD SSFNFMAFFF TFSAQLVISI
     IQAVGIPGWG VCGWIATVGF FGTSVGAAVV MLFPTILFTA VAVLSFVALT KVHRFYRGAG
     GSLSKAQEEW TTGAWKNPHV QQAAQNAAQG AMSHNDPQYS ATPNYGYSNQ M