ID   SCAMP_CANLF             Reviewed;         110 AA.
AC   Q9GLJ9; Q28261;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Putative protein SCAMPER;
DE   AltName: Full=Sphingolipid calcium release-mediating protein of the endoplasmic reticulum;
DE            Short=SCaMPER;
GN   Name=SCAMPER;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Kidney;
RX   PubMed=8700873; DOI=10.1073/pnas.93.5.1993;
RA   Mao C., Kim S.H., Almenoff J.S., Rudner X.L., Kearney D.M., Kindman L.A.;
RT   "Molecular cloning and characterization of SCaMPER, a sphingolipid Ca2+
RT   release-mediating protein from endoplasmic reticulum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:1993-1996(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RX   PubMed=11829755; DOI=10.1042/0264-6021:3620183;
RA   Schnurbus R., de Pietri Tonelli D., Grohovaz F., Zacchetti D.;
RT   "Re-evaluation of primary structure, topology, and localization of Scamper,
RT   a putative intracellular Ca2+ channel activated by
RT   sphingosylphosphocholine.";
RL   Biochem. J. 362:183-189(2002).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=12421694; DOI=10.1152/ajpcell.00382.2002;
RA   Cavalli A.L., O'Brien N.W., Barlow S.B., Betto R., Glembotski C.C.,
RA   Palade P.T., Sabbadini R.A.;
RT   "Expression and functional characterization of SCaMPER: a sphingolipid-
RT   modulated calcium channel of cardiomyocytes.";
RL   Am. J. Physiol. 284:C780-C790(2003).
CC   -!- FUNCTION: Putative sphingolipid-gated calcium channel.
CC       {ECO:0000269|PubMed:8700873}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum. Sarcoplasmic reticulum
CC       membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
CC       Note=Localizes to the sarcotubular junctions where T tubules connect to
CC       the sarcoplasmic reticulum. {ECO:0000250}.
CC   -!- CAUTION: According to PubMed:11829755, the data associated with
CC       PubMed:8700873 are to be considered with caution due to a frameshift in
CC       the cDNA used for the experiments. {ECO:0000305}.
CC   -!- CAUTION: According to PubMed:12421694, orthologs exist in human (AC
CC       Q8IWQ8) and rat (AC Q8CGM6). However, the submitted sequences do not
CC       match human and rat reference genome assemblies, suggesting that they
CC       are artifactual and that SCAMPER most probably does not exist in human
CC       and rat. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC48538.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U33628; AAC48538.1; ALT_FRAME; mRNA.
DR   EMBL; AF263546; AAG23168.1; -; mRNA.
DR   RefSeq; NP_001003197.2; NM_001003197.2.
DR   AlphaFoldDB; Q9GLJ9; -.
DR   PaxDb; Q9GLJ9; -.
DR   Ensembl; ENSCAFT00030015590; ENSCAFP00030013585; ENSCAFG00030008495.
DR   Ensembl; ENSCAFT00040022749; ENSCAFP00040019713; ENSCAFG00040012340.
DR   Ensembl; ENSCAFT00845047474; ENSCAFP00845037250; ENSCAFG00845026947.
DR   GeneID; 403847; -.
DR   KEGG; cfa:403847; -.
DR   CTD; 403847; -.
DR   VEuPathDB; HostDB:ENSCAFG00845026947; -.
DR   GeneTree; ENSGT00950000185491; -.
DR   HOGENOM; CLU_2170142_0_0_1; -.
DR   OMA; WRNIFIY; -.
DR   Proteomes; UP000002254; Chromosome 5.
DR   Bgee; ENSCAFG00000019657; Expressed in lymph node and 24 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Sarcoplasmic reticulum; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..110
FT                   /note="Putative protein SCAMPER"
FT                   /id="PRO_0000392602"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   110 AA;  12418 MW;  2F114AE014CB812C CRC64;
     MLKVSRVSSE GLISLSITEA PDLKIRDPKI EKLYLPVFYL NAHIYLNALS TLLNSHCGEN
     CFHGYEQLQN ATFPVWRNIF IYINRVRNIK RQGGGGGVSG KGEMKQCFLS