SCAPE_HUMAN
ID SCAPE_HUMAN Reviewed; 1400 AA.
AC Q9BY12; F5H7X8; H3BNR7; Q3B7X7; Q96BS9; Q9H3D8; Q9NT03; Q9P274;
DT 15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2013, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=S phase cyclin A-associated protein in the endoplasmic reticulum {ECO:0000305};
DE Short=S phase cyclin A-associated protein in the ER;
DE AltName: Full=Zinc finger protein 291;
GN Name=SCAPER {ECO:0000312|HGNC:HGNC:13081}; Synonyms=KIAA1454, ZNF291;
GN ORFNames=MSTP063;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Carim-Todd L., Sumoy L., Estivill X., Escarceller M.;
RT "Identification and characterization of ZNF291, a novel protein on
RT chromosome 15q24.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-1089.
RC TISSUE=Brain;
RX PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:143-150(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1135-1400 (ISOFORM 1).
RC TISSUE=Retina, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-551 AND 1024-1340 (ISOFORM 1).
RC TISSUE=Colon, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 246-1340 (ISOFORM 1), AND VARIANT
RP THR-1089.
RC TISSUE=Heart;
RA Zhao B., Xu Y.Y., Liu Y.Q., Wang X.Y., Lui B., Ye J., Song L., Zhao Y.,
RA Cao H.Q., Zhao X.W., Gao Y., Zhang C.L., Zhang J., Liu L.S., Ding J.F.,
RA Gao R.L., Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T.;
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1109-1400 (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP FUNCTION, INTERACTION WITH CCNA2/CDK2 COMPLEX, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF 26-ARG--LEU-28;
RP 199-ARG--LEU-201 AND 678-ARG--LEU-680.
RX PubMed=17698606; DOI=10.1083/jcb.200701166;
RA Tsang W.Y., Wang L., Chen Z., Sanchez I., Dynlacht B.D.;
RT "SCAPER, a novel cyclin A-interacting protein that regulates cell cycle
RT progression.";
RL J. Cell Biol. 178:621-633(2007).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP INVOLVEMENT IN IDDRP, TISSUE SPECIFICITY, AND VARIANTS IDDRP GLU-620 DEL
RP AND ASN-1219.
RX PubMed=28794130; DOI=10.1136/jmedgenet-2017-104632;
RA Tatour Y., Sanchez-Navarro I., Chervinsky E., Hakonarson H., Gawi H.,
RA Tahsin-Swafiri S., Leibu R., Lopez-Molina M.I., Fernandez-Sanz G.,
RA Ayuso C., Ben-Yosef T.;
RT "Mutations in SCAPER cause autosomal recessive retinitis pigmentosa with
RT intellectual disability.";
RL J. Med. Genet. 54:698-704(2017).
CC -!- FUNCTION: CCNA2/CDK2 regulatory protein that transiently maintains
CC CCNA2 in the cytoplasm. {ECO:0000269|PubMed:17698606}.
CC -!- SUBUNIT: Interacts with CCNA2/CDK2 complex, but not with CCNA2/CDC2,
CC CCNB1/CDC2 or CCNE1/CDK2 complexes, at multiple phases of the cell
CC cycle, including S and G2/M. {ECO:0000269|PubMed:17698606}.
CC -!- INTERACTION:
CC Q9BY12; P24941: CDK2; NbExp=3; IntAct=EBI-308519, EBI-375096;
CC Q9BY12-3; Q9Y5Z0: BACE2; NbExp=3; IntAct=EBI-25837959, EBI-11282723;
CC Q9BY12-3; P46379-2: BAG6; NbExp=3; IntAct=EBI-25837959, EBI-10988864;
CC Q9BY12-3; P28329-3: CHAT; NbExp=3; IntAct=EBI-25837959, EBI-25837549;
CC Q9BY12-3; P02489: CRYAA; NbExp=3; IntAct=EBI-25837959, EBI-6875961;
CC Q9BY12-3; O75190-2: DNAJB6; NbExp=3; IntAct=EBI-25837959, EBI-12593112;
CC Q9BY12-3; P50570-2: DNM2; NbExp=3; IntAct=EBI-25837959, EBI-10968534;
CC Q9BY12-3; Q14204: DYNC1H1; NbExp=3; IntAct=EBI-25837959, EBI-356015;
CC Q9BY12-3; P22607: FGFR3; NbExp=3; IntAct=EBI-25837959, EBI-348399;
CC Q9BY12-3; Q8TB36: GDAP1; NbExp=3; IntAct=EBI-25837959, EBI-11110431;
CC Q9BY12-3; P14136: GFAP; NbExp=3; IntAct=EBI-25837959, EBI-744302;
CC Q9BY12-3; O14908-2: GIPC1; NbExp=3; IntAct=EBI-25837959, EBI-25913156;
CC Q9BY12-3; P01112: HRAS; NbExp=3; IntAct=EBI-25837959, EBI-350145;
CC Q9BY12-3; P42858: HTT; NbExp=6; IntAct=EBI-25837959, EBI-466029;
CC Q9BY12-3; O14901: KLF11; NbExp=3; IntAct=EBI-25837959, EBI-948266;
CC Q9BY12-3; Q92876: KLK6; NbExp=3; IntAct=EBI-25837959, EBI-2432309;
CC Q9BY12-3; P35240: NF2; NbExp=3; IntAct=EBI-25837959, EBI-1014472;
CC Q9BY12-3; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-25837959, EBI-2811583;
CC Q9BY12-3; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-25837959, EBI-5235340;
CC Q9BY12-3; O14656-2: TOR1A; NbExp=3; IntAct=EBI-25837959, EBI-25847109;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:17698606}. Nucleus {ECO:0000269|PubMed:17698606}.
CC Note=Predominantly located in the endoplasmic reticulum, only a small
CC portion is detected in the nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BY12-1; Sequence=Displayed;
CC Name=3;
CC IsoId=Q9BY12-3; Sequence=VSP_046503;
CC -!- TISSUE SPECIFICITY: Widely expressed with high expression in testis.
CC Isoform 1 is detected in various tissues, including retina, fetal and
CC adult brain. Isoform 2 is expressed in the retina at high levels, and
CC in the brain at very low levels (PubMed:28794130).
CC {ECO:0000269|PubMed:17698606, ECO:0000269|PubMed:28794130}.
CC -!- DEVELOPMENTAL STAGE: Expressed at each stage of the cell cycle,
CC including G0, although the expression is somewhat higher in late G1 and
CC S phases. {ECO:0000269|PubMed:17698606}.
CC -!- PTM: Phosphorylated in vitro by the CCNA2/CDK2 complex.
CC -!- DISEASE: Intellectual developmental disorder and retinitis pigmentosa
CC (IDDRP) [MIM:618195]: An autosomal recessive disease characterized by
CC mild to moderate intellectual disability, retinitis pigmentosa, and
CC attention-deficit hyperactivity disorder observed in some patients.
CC {ECO:0000269|PubMed:28794130}. Note=The disease may be caused by
CC variants affecting the gene represented in this entry.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG47945.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH15212.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI07416.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=AAK29205.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA95978.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AF242528; AAK29205.1; ALT_INIT; mRNA.
DR EMBL; AB040887; BAA95978.1; ALT_SEQ; mRNA.
DR EMBL; AL137612; CAB70841.1; -; mRNA.
DR EMBL; BX647285; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC015798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC016343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC027243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC051643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471136; EAW99218.1; -; Genomic_DNA.
DR EMBL; BC015212; AAH15212.1; ALT_INIT; mRNA.
DR EMBL; BC107415; AAI07416.1; ALT_SEQ; mRNA.
DR EMBL; AF119814; AAG47945.1; ALT_INIT; mRNA.
DR EMBL; BT006762; AAP35408.1; -; mRNA.
DR CCDS; CCDS53961.1; -. [Q9BY12-3]
DR CCDS; CCDS53962.1; -. [Q9BY12-1]
DR PIR; T46314; T46314.
DR RefSeq; NP_001139395.1; NM_001145923.1. [Q9BY12-3]
DR RefSeq; NP_065894.2; NM_020843.2. [Q9BY12-1]
DR RefSeq; XP_005254476.1; XM_005254419.2.
DR RefSeq; XP_016877758.1; XM_017022269.1. [Q9BY12-1]
DR RefSeq; XP_016877759.1; XM_017022270.1. [Q9BY12-1]
DR AlphaFoldDB; Q9BY12; -.
DR SMR; Q9BY12; -.
DR BioGRID; 119067; 22.
DR IntAct; Q9BY12; 35.
DR STRING; 9606.ENSP00000454973; -.
DR iPTMnet; Q9BY12; -.
DR PhosphoSitePlus; Q9BY12; -.
DR BioMuta; SCAPER; -.
DR DMDM; 510120715; -.
DR EPD; Q9BY12; -.
DR jPOST; Q9BY12; -.
DR MassIVE; Q9BY12; -.
DR MaxQB; Q9BY12; -.
DR PaxDb; Q9BY12; -.
DR PeptideAtlas; Q9BY12; -.
DR PRIDE; Q9BY12; -.
DR ProteomicsDB; 27620; -.
DR ProteomicsDB; 41275; -.
DR ProteomicsDB; 79561; -. [Q9BY12-1]
DR Antibodypedia; 27436; 70 antibodies from 17 providers.
DR DNASU; 49855; -.
DR Ensembl; ENST00000324767.11; ENSP00000326924.7; ENSG00000140386.13. [Q9BY12-1]
DR Ensembl; ENST00000538941.6; ENSP00000442190.2; ENSG00000140386.13. [Q9BY12-3]
DR Ensembl; ENST00000563290.6; ENSP00000454973.1; ENSG00000140386.13. [Q9BY12-1]
DR GeneID; 49855; -.
DR KEGG; hsa:49855; -.
DR MANE-Select; ENST00000563290.6; ENSP00000454973.1; NM_020843.4; NP_065894.2.
DR UCSC; uc002bbx.4; human. [Q9BY12-1]
DR CTD; 49855; -.
DR DisGeNET; 49855; -.
DR GeneCards; SCAPER; -.
DR HGNC; HGNC:13081; SCAPER.
DR HPA; ENSG00000140386; Tissue enhanced (retina).
DR MalaCards; SCAPER; -.
DR MIM; 611611; gene.
DR MIM; 618195; phenotype.
DR neXtProt; NX_Q9BY12; -.
DR OpenTargets; ENSG00000140386; -.
DR Orphanet; 110; Bardet-Biedl syndrome.
DR Orphanet; 791; Retinitis pigmentosa.
DR PharmGKB; PA162402512; -.
DR VEuPathDB; HostDB:ENSG00000140386; -.
DR eggNOG; KOG4722; Eukaryota.
DR GeneTree; ENSGT00390000011159; -.
DR HOGENOM; CLU_005178_0_0_1; -.
DR InParanoid; Q9BY12; -.
DR OMA; CEHPLAE; -.
DR OrthoDB; 82115at2759; -.
DR PhylomeDB; Q9BY12; -.
DR TreeFam; TF324831; -.
DR PathwayCommons; Q9BY12; -.
DR SignaLink; Q9BY12; -.
DR BioGRID-ORCS; 49855; 15 hits in 1078 CRISPR screens.
DR ChiTaRS; SCAPER; human.
DR GenomeRNAi; 49855; -.
DR Pharos; Q9BY12; Tbio.
DR PRO; PR:Q9BY12; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q9BY12; protein.
DR Bgee; ENSG00000140386; Expressed in cortical plate and 189 other tissues.
DR ExpressionAtlas; Q9BY12; baseline and differential.
DR Genevisible; Q9BY12; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:1990917; C:ooplasm; IEA:Ensembl.
DR GO; GO:0061827; C:sperm head; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0001547; P:antral ovarian follicle growth; IEA:Ensembl.
DR GO; GO:0060041; P:retina development in camera-type eye; IMP:MGI.
DR GO; GO:0072520; P:seminiferous tubule development; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR032446; SCAPER_N.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR Pfam; PF16501; SCAPER_N; 1.
DR SMART; SM00451; ZnF_U1; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disease variant; Endoplasmic reticulum;
KW Intellectual disability; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Retinitis pigmentosa; Zinc; Zinc-finger.
FT CHAIN 1..1400
FT /note="S phase cyclin A-associated protein in the
FT endoplasmic reticulum"
FT /id="PRO_0000047513"
FT ZN_FING 792..816
FT /note="C2H2-type"
FT REGION 36..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 832
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..257
FT /note="MMASFQRSNSHDKVRRIVAEEGRTARNLIAWSVPLESKDDDGKPKCQTGGKS
FT KRTIQGTHKTTKQSTAVDCKITSSTTGDKHFDKSPTKTRHPRKIDLRARYWAFLFDNLR
FT RAVDEIYVTCESDQSVVECKEVLMMLDNYVRDFKALIDWIQLQEKLEKTDAQSRPTSLA
FT WEVKKMSPGRHVIPSPSTDRINVTSNARRSLNFGGSTGTVPAPRLAPTGVSWADKVKAH
FT HTGSTASSEITPAQSCPPMTVQKASRKN -> MKTKYIFCNIT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_046503"
FT VARIANT 620
FT /note="Missing (in IDDRP; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:28794130"
FT /id="VAR_081681"
FT VARIANT 1089
FT /note="P -> T (in dbSNP:rs1607017)"
FT /evidence="ECO:0000269|PubMed:10819331, ECO:0000269|Ref.7"
FT /id="VAR_019978"
FT VARIANT 1139
FT /note="A -> T (in dbSNP:rs3743176)"
FT /id="VAR_059910"
FT VARIANT 1140
FT /note="A -> T (in dbSNP:rs3743176)"
FT /id="VAR_052806"
FT VARIANT 1219
FT /note="S -> N (in IDDRP; unknown pathological significance;
FT dbSNP:rs1305542291)"
FT /evidence="ECO:0000269|PubMed:28794130"
FT /id="VAR_081682"
FT MUTAGEN 26..28
FT /note="RNL->AAA: No effect on CCNA2/CDK2 complex-binding."
FT /evidence="ECO:0000269|PubMed:17698606"
FT MUTAGEN 199..201
FT /note="RSL->AAA: Loss of CCNA2/CDK2 complex-binding."
FT /evidence="ECO:0000269|PubMed:17698606"
FT MUTAGEN 678..680
FT /note="RAL->AAA: No effect on CCNA2/CDK2 complex-binding."
FT /evidence="ECO:0000269|PubMed:17698606"
FT CONFLICT 1
FT /note="M -> V (in Ref. 1; AAK29205)"
FT /evidence="ECO:0000305"
FT CONFLICT 1262
FT /note="S -> F (in Ref. 7; AAG47945)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1400 AA; 158287 MW; 9DBAF02F75CB1AA7 CRC64;
MMASFQRSNS HDKVRRIVAE EGRTARNLIA WSVPLESKDD DGKPKCQTGG KSKRTIQGTH
KTTKQSTAVD CKITSSTTGD KHFDKSPTKT RHPRKIDLRA RYWAFLFDNL RRAVDEIYVT
CESDQSVVEC KEVLMMLDNY VRDFKALIDW IQLQEKLEKT DAQSRPTSLA WEVKKMSPGR
HVIPSPSTDR INVTSNARRS LNFGGSTGTV PAPRLAPTGV SWADKVKAHH TGSTASSEIT
PAQSCPPMTV QKASRKNERK DAEGWETVQR GRPIRSRSTA VMPKVSLATE ATRSKDDSDK
ENVCLLPDES IQKGQFVGDG TSNTIESHPK DSLHSCDHPL AEKTQFTVST LDDVKNSGSI
RDNYVRTSEI SAVHIDTECV SVMLQAGTPP LQVNEEKFPA EKARIENEMD PSDISNSMAE
VLAKKEELAD RLEKANEEAI ASAIAEEEQL TREIEAEENN DINIETDNDS DFSASMGSGS
VSFCGMSMDW NDVLADYEAR ESWRQNTSWG DIVEEEPARP PGHGIHMHEK LSSPSRKRTI
AESKKKHEEK QMKAQQLREK LREEKTLKLQ KLLEREKDVR KWKEELLDQR RRMMEEKLLH
AEFKREVQLQ AIVKKAQEEE AKVNEIAFIN TLEAQNKRHD VLSKLKEYEQ RLNELQEERQ
RRQEEKQARD EAVQERKRAL EAERQARVEE LLMKRKEQEA RIEQQRQEKE KAREDAARER
ARDREERLAA LTAAQQEAME ELQKKIQLKH DESIRRHMEQ IEQRKEKAAE LSSGRHANTD
YAPKLTPYER KKQCSLCNVL ISSEVYLFSH VKGRKHQQAV RENTSIQGRE LSDEEVEHLS
LKKYIIDIVV ESTAPAEALK DGEERQKNKK KAKKIKARMN FRAKEYESLM ETKNSGSDSP
YKAKLQRLAK DLLKQVQVQD SGSWANNKVS ALDRTLGEIT RILEKENVAD QIAFQAAGGL
TALEHILQAV VPATNVNTVL RIPPKSLCNA INVYNLTCNN CSENCSDVLF SNKITFLMDL
LIHQLTVYVP DENNTILGRN TNKQVFEGLT TGLLKVSAVV LGCLIANRPD GNCQPATPKI
PTQEMKNKPS QGDPFNNRVQ DLISYVVNMG LIDKLCACFL SVQGPVDENP KMAIFLQHAA
GLLHAMCTLC FAVTGRSYSI FDNNRQDPTG LTAALQATDL AGVLHMLYCV LFHGTILDPS
TASPKENYTQ NTIQVAIQSL RFFNSFAALH LPAFQSIVGA EGLSLAFRHM ASSLLGHCSQ
VSCESLLHEV IVCVGYFTVN HPDNQVIVQS GRHPTVLQKL CQLPFQYFSD PRLIKVLFPS
LIAACYNNHQ NKIILEQEMS CVLLATFIQD LAQTPGQAEN QPYQPKGKCL GSQDYLELAN
RFPQQAWEEA RQFFLKKEKK
