SCAR3_HUMAN
ID SCAR3_HUMAN Reviewed; 606 AA.
AC Q6AZY7; Q9UM15; Q9UM16;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Scavenger receptor class A member 3;
DE AltName: Full=Cellular stress response gene protein;
GN Name=SCARA3; Synonyms=CSR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=9580669; DOI=10.1093/hmg/7.6.1039;
RA Han H.-J., Tokino T., Nakamura Y.;
RT "CSR, a scavenger receptor-like protein with a protective role against
RT cellular damage caused by UV irradiation and oxidative stress.";
RL Hum. Mol. Genet. 7:1039-1046(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLN-130; THR-325; GLN-423;
RP ILE-428; LEU-467 AND SER-551.
RG NIEHS SNPs program;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Seems to protect cells by scavenging oxidative molecules or
CC harmful products of oxidation. {ECO:0000269|PubMed:9580669}.
CC -!- INTERACTION:
CC Q6AZY7; O43760: SYNGR2; NbExp=3; IntAct=EBI-8657660, EBI-2826419;
CC Q6AZY7-2; P05067: APP; NbExp=3; IntAct=EBI-21598366, EBI-77613;
CC Q6AZY7-2; P19404: NDUFV2; NbExp=3; IntAct=EBI-21598366, EBI-713665;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:9580669}; Single-pass type II membrane protein
CC {ECO:0000269|PubMed:9580669}. Golgi apparatus membrane
CC {ECO:0000269|PubMed:9580669}; Single-pass type II membrane protein
CC {ECO:0000269|PubMed:9580669}. Note=Endoplasmic reticulum and/or Golgi.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=CSR1;
CC IsoId=Q6AZY7-1; Sequence=Displayed;
CC Name=2; Synonyms=CSR2;
CC IsoId=Q6AZY7-2; Sequence=VSP_017135, VSP_017136;
CC -!- TISSUE SPECIFICITY: Expressed ubiquitously.
CC {ECO:0000269|PubMed:9580669}.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/scara3/";
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DR EMBL; AB007829; BAA86201.1; -; mRNA.
DR EMBL; AB007830; BAA86202.1; -; mRNA.
DR EMBL; DQ205185; ABA27098.1; -; Genomic_DNA.
DR EMBL; BC060811; AAH60811.1; -; mRNA.
DR EMBL; BC075067; AAH75067.1; -; mRNA.
DR EMBL; BC075068; AAH75068.1; -; mRNA.
DR CCDS; CCDS34870.1; -. [Q6AZY7-2]
DR CCDS; CCDS34871.1; -. [Q6AZY7-1]
DR RefSeq; NP_057324.2; NM_016240.2. [Q6AZY7-1]
DR RefSeq; NP_878185.1; NM_182826.1. [Q6AZY7-2]
DR RefSeq; XP_016869024.1; XM_017013535.1. [Q6AZY7-1]
DR AlphaFoldDB; Q6AZY7; -.
DR SMR; Q6AZY7; -.
DR BioGRID; 119539; 117.
DR IntAct; Q6AZY7; 31.
DR MINT; Q6AZY7; -.
DR STRING; 9606.ENSP00000301904; -.
DR GlyGen; Q6AZY7; 10 sites.
DR iPTMnet; Q6AZY7; -.
DR PhosphoSitePlus; Q6AZY7; -.
DR BioMuta; SCARA3; -.
DR DMDM; 74736352; -.
DR jPOST; Q6AZY7; -.
DR MassIVE; Q6AZY7; -.
DR MaxQB; Q6AZY7; -.
DR PaxDb; Q6AZY7; -.
DR PeptideAtlas; Q6AZY7; -.
DR PRIDE; Q6AZY7; -.
DR ProteomicsDB; 66202; -. [Q6AZY7-1]
DR ProteomicsDB; 66203; -. [Q6AZY7-2]
DR Antibodypedia; 23041; 119 antibodies from 27 providers.
DR DNASU; 51435; -.
DR Ensembl; ENST00000301904.4; ENSP00000301904.3; ENSG00000168077.14. [Q6AZY7-1]
DR Ensembl; ENST00000337221.8; ENSP00000337985.3; ENSG00000168077.14. [Q6AZY7-2]
DR GeneID; 51435; -.
DR KEGG; hsa:51435; -.
DR MANE-Select; ENST00000301904.4; ENSP00000301904.3; NM_016240.3; NP_057324.2.
DR UCSC; uc003xga.2; human. [Q6AZY7-1]
DR CTD; 51435; -.
DR DisGeNET; 51435; -.
DR GeneCards; SCARA3; -.
DR HGNC; HGNC:19000; SCARA3.
DR HPA; ENSG00000168077; Tissue enhanced (brain).
DR MIM; 602728; gene.
DR neXtProt; NX_Q6AZY7; -.
DR OpenTargets; ENSG00000168077; -.
DR PharmGKB; PA38775; -.
DR VEuPathDB; HostDB:ENSG00000168077; -.
DR eggNOG; ENOG502QV37; Eukaryota.
DR GeneTree; ENSGT00940000158238; -.
DR HOGENOM; CLU_027961_0_0_1; -.
DR InParanoid; Q6AZY7; -.
DR OMA; GPHCSRC; -.
DR OrthoDB; 508661at2759; -.
DR PhylomeDB; Q6AZY7; -.
DR TreeFam; TF332426; -.
DR PathwayCommons; Q6AZY7; -.
DR SignaLink; Q6AZY7; -.
DR BioGRID-ORCS; 51435; 8 hits in 1072 CRISPR screens.
DR ChiTaRS; SCARA3; human.
DR GenomeRNAi; 51435; -.
DR Pharos; Q6AZY7; Tbio.
DR PRO; PR:Q6AZY7; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q6AZY7; protein.
DR Bgee; ENSG00000168077; Expressed in calcaneal tendon and 161 other tissues.
DR Genevisible; Q6AZY7; HS.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005044; F:scavenger receptor activity; TAS:ProtInc.
DR GO; GO:0006979; P:response to oxidative stress; TAS:ProtInc.
DR GO; GO:0009650; P:UV protection; TAS:ProtInc.
DR InterPro; IPR008160; Collagen.
DR Pfam; PF01391; Collagen; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Collagen; Endoplasmic reticulum; Glycoprotein;
KW Golgi apparatus; Membrane; Reference proteome; Repeat; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..606
FT /note="Scavenger receptor class A member 3"
FT /id="PRO_0000181633"
FT TOPO_DOM 1..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..606
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 455..513
FT /note="Collagen-like 1"
FT DOMAIN 544..603
FT /note="Collagen-like 2"
FT REGION 454..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..559
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..606
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 224
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 313
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 337
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 365
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 400
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 430
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 451
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 458..466
FT /note="APGPPGPRG -> HTLFSHNRI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:9580669"
FT /id="VSP_017135"
FT VAR_SEQ 467..606
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:9580669"
FT /id="VSP_017136"
FT VARIANT 130
FT /note="R -> Q (in dbSNP:rs34791518)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_025228"
FT VARIANT 325
FT /note="M -> T (in dbSNP:rs33930667)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_025229"
FT VARIANT 423
FT /note="R -> Q (in dbSNP:rs3735754)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_025230"
FT VARIANT 428
FT /note="V -> I (in dbSNP:rs34086286)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_025231"
FT VARIANT 467
FT /note="F -> L (in dbSNP:rs17057523)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_025232"
FT VARIANT 551
FT /note="P -> S (in dbSNP:rs35928641)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_025233"
FT CONFLICT 488
FT /note="S -> I (in Ref. 1; BAA86201)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 606 AA; 65137 MW; 15EEC028AAF7762E CRC64;
MKVRSAGGDG DALCVTEEDL AGDDEDMPTF PCTQKGRPGP RCSRCQKNLS LHTSVRILYL
FLALLLVAVA VLASLVFRKV DSLSEDISLT QSIYDKKLVL MQKNLQGLDP KALNNCSFCH
EAGQLGPEIR KLQEELEGIQ KLLLAQEVQL DQTLQAQEVL STTSRQISQE MGSCSFSIHQ
VNQSLGLFLA QVRGWQATTA GLDLSLKDLT QECYDVKAAV HQINFTVGQT SEWIHGIQRK
TDEETLTLQK IVTDWQNYTR LFSGLRTTST KTGEAVKNIQ ATLGASSQRI SQNSESMHDL
VLQVMGLQLQ LDNISSFLDD HEENMHDLQY HTHYAQNRTV ERFESLEGRM ASHEIEIGTI
FTNINATDNH VHSMLKYLDD VRLSCTLGFH THAEELYYLN KSVSIMLGTT DLLRERFSLL
SARLDLNVRN LSMIVEEMKA VDTQHGEILR NVTILRGAPG PPGPRGFKGD MGVKGPVGGR
GPKGDPGSLG PLGPQGPQGQ PGEAGPVGER GPVGPRGFPG LKGSKGSFGT GGPRGQPGPK
GDIGPPGPEG PPGSPGPSGP QGKPGIAGKT GSPGQRGAMG PKGEPGIQGP PGLPGPPGPP
GSQSFY
