SCAR3_MOUSE
ID SCAR3_MOUSE Reviewed; 606 AA.
AC Q8C850; Q8C6N1;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Scavenger receptor class A member 3;
GN Name=Scara3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Oviduct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Seems to protect cells by scavenging oxidative molecules or
CC harmful products of oxidation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus
CC membrane {ECO:0000250}; Single-pass type II membrane protein
CC {ECO:0000250}. Note=Endoplasmic reticulum and/or Golgi. {ECO:0000250}.
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DR EMBL; AK048423; BAC33332.1; -; mRNA.
DR EMBL; AK054188; BAC35687.1; -; mRNA.
DR EMBL; BC051636; AAH51636.2; -; mRNA.
DR CCDS; CCDS49524.1; -.
DR RefSeq; NP_766192.1; NM_172604.3.
DR AlphaFoldDB; Q8C850; -.
DR SMR; Q8C850; -.
DR STRING; 10090.ENSMUSP00000046525; -.
DR GlyGen; Q8C850; 10 sites.
DR iPTMnet; Q8C850; -.
DR PhosphoSitePlus; Q8C850; -.
DR jPOST; Q8C850; -.
DR MaxQB; Q8C850; -.
DR PaxDb; Q8C850; -.
DR PRIDE; Q8C850; -.
DR ProteomicsDB; 256740; -.
DR Antibodypedia; 23041; 119 antibodies from 27 providers.
DR DNASU; 219151; -.
DR Ensembl; ENSMUST00000042046; ENSMUSP00000046525; ENSMUSG00000034463.
DR GeneID; 219151; -.
DR KEGG; mmu:219151; -.
DR UCSC; uc007ujr.1; mouse.
DR CTD; 51435; -.
DR MGI; MGI:2444418; Scara3.
DR VEuPathDB; HostDB:ENSMUSG00000034463; -.
DR eggNOG; ENOG502QV37; Eukaryota.
DR GeneTree; ENSGT00940000158238; -.
DR HOGENOM; CLU_027961_0_0_1; -.
DR InParanoid; Q8C850; -.
DR OMA; GPHCSRC; -.
DR OrthoDB; 508661at2759; -.
DR PhylomeDB; Q8C850; -.
DR TreeFam; TF332426; -.
DR BioGRID-ORCS; 219151; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8C850; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8C850; protein.
DR Bgee; ENSMUSG00000034463; Expressed in molar tooth and 213 other tissues.
DR Genevisible; Q8C850; MM.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IBA:GO_Central.
DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR InterPro; IPR008160; Collagen.
DR Pfam; PF01391; Collagen; 3.
PE 2: Evidence at transcript level;
KW Collagen; Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Membrane;
KW Reference proteome; Repeat; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..606
FT /note="Scavenger receptor class A member 3"
FT /id="PRO_0000181634"
FT TOPO_DOM 1..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..606
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 456..558
FT /note="Collagen-like 1"
FT DOMAIN 559..601
FT /note="Collagen-like 2"
FT REGION 455..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..501
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..559
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..606
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 224
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 313
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 337
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 365
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 400
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 430
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 451
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 241
FT /note="T -> I (in Ref. 1; BAC35687)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 606 AA; 65471 MW; 7D72ED778397DA36 CRC64;
MKVRSAGSDR DVLCVTEEDL AGEDEDMPSF PCTQEGRAGP RCNRCQKNLS LHTSVRILYL
FLTLLLVAVA VLASLVFRKV DSLSEDISLA QSIYNKKLVS MQENLQGLDP KALINCSFCR
EAEQLGQEIR KVQEELEGLQ KMLLAQEVQL DQTSQTHELL STRSSQISQE MGSCSFSIHQ
VNQSLGLFLA QVRGWQATTA GMDITLKDLT QECYDVKAAV HQINFTVGQT AEWIHGIQRK
TDEETLTLQK IVTDWQNYTR LFGGLRTTSA KTGEIVKTIQ TTLGASSQRI SQNSESMHDL
VLQVMGLQLQ LDNISSFLDD HEENMHDLQY HTRYAQNRTV ERFESLEGRM ASHEIEIGTI
FTNINATDNH VHSMLKYLDD VRLSCTLGFH THAEELYYLN KSVSLMLGTT DLLRERFSLL
SARLDFNVRN LSMIMEEMKA VDTHHGEILR NVTVIRGVPG PPGPRGLKGD TGVKGPVGSR
GPKGDPGNLG PPGPQGPQGQ PGEPGPVGER GPAGPRGFPG LKGSKGSFGT GGPRGQPGPK
GDVGPLGPEG PPGSPGPSGP QGKPGISGKT GSPGQRGATG PKGEPGIQGP PGLPGPPGPP
GNQSPY
