SCC11_ARATH
ID SCC11_ARATH Reviewed; 627 AA.
AC Q9S7T7; Q3E9L1; Q9SQI1;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Sister chromatid cohesion 1 protein 1;
DE AltName: Full=Protein DETERMINATE INFERTILE 1;
DE AltName: Full=SCC1 homolog 1;
GN Name=SYN1; Synonyms=DIF1; OrderedLocusNames=At5g05490; ORFNames=MOP10.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND ALTERNATIVE PROMOTER
RP USAGE.
RC STRAIN=cv. Wassilewskija;
RX PubMed=10072401; DOI=10.2307/3870870;
RA Bai X., Peirson B.N., Dong F., Xue C., Makaroff C.A.;
RT "Isolation and characterization of SYN1, a RAD21-like gene essential for
RT meiosis in Arabidopsis.";
RL Plant Cell 11:417-430(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=cv. Landsberg erecta;
RX PubMed=10504568; DOI=10.1046/j.1365-313x.1999.00548.x;
RA Bhatt A.M., Lister C., Page T., Fransz P.F., Findlay K., Jones G.H.,
RA Dickinson H.G., Dean C.;
RT "The DIF1 gene of Arabidopsis is required for meiotic chromosome
RT segregation and belongs to the REC8/RAD21 cohesin gene family.";
RL Plant J. 19:463-472(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Involved in chromosome condensation, pairing and segregation
CC during meiosis. Responsible for cohesion between replicated sister
CC chromatids.
CC -!- SUBUNIT: Component of the cohesin complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage; Named isoforms=2;
CC Name=2;
CC IsoId=Q9S7T7-1; Sequence=Displayed;
CC Name=1;
CC IsoId=Q9S7T7-2; Sequence=VSP_007492;
CC -!- TISSUE SPECIFICITY: Isoform 2 is expressed at low levels in buds,
CC leaves and roots, whereas expression of isoform 1 is confined to buds.
CC -!- SIMILARITY: Belongs to the rad21 family. {ECO:0000305}.
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DR EMBL; AF080620; AAF08982.1; -; mRNA.
DR EMBL; AF080619; AAF08981.1; -; mRNA.
DR EMBL; AJ238306; CAB64643.1; -; mRNA.
DR EMBL; AB005241; BAB11538.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90879.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90880.1; -; Genomic_DNA.
DR PIR; T52571; T52571.
DR RefSeq; NP_196168.1; NM_120631.2. [Q9S7T7-2]
DR RefSeq; NP_850773.1; NM_180442.2. [Q9S7T7-1]
DR AlphaFoldDB; Q9S7T7; -.
DR STRING; 3702.AT5G05490.1; -.
DR PaxDb; Q9S7T7; -.
DR PRIDE; Q9S7T7; -.
DR ProteomicsDB; 232936; -. [Q9S7T7-1]
DR EnsemblPlants; AT5G05490.1; AT5G05490.1; AT5G05490. [Q9S7T7-1]
DR EnsemblPlants; AT5G05490.2; AT5G05490.2; AT5G05490. [Q9S7T7-2]
DR GeneID; 830432; -.
DR Gramene; AT5G05490.1; AT5G05490.1; AT5G05490. [Q9S7T7-1]
DR Gramene; AT5G05490.2; AT5G05490.2; AT5G05490. [Q9S7T7-2]
DR KEGG; ath:AT5G05490; -.
DR Araport; AT5G05490; -.
DR TAIR; locus:2169667; AT5G05490.
DR eggNOG; KOG1213; Eukaryota.
DR InParanoid; Q9S7T7; -.
DR OMA; THDFIKV; -.
DR OrthoDB; 345127at2759; -.
DR PhylomeDB; Q9S7T7; -.
DR PRO; PR:Q9S7T7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9S7T7; baseline and differential.
DR Genevisible; Q9S7T7; AT.
DR GO; GO:0005694; C:chromosome; IDA:TAIR.
DR GO; GO:0008278; C:cohesin complex; ISS:TAIR.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0051276; P:chromosome organization; IMP:TAIR.
DR GO; GO:0010032; P:meiotic chromosome condensation; IMP:TAIR.
DR GO; GO:0051754; P:meiotic sister chromatid cohesion, centromeric; IMP:TAIR.
DR GO; GO:0051455; P:monopolar spindle attachment to meiosis I kinetochore; IMP:TAIR.
DR GO; GO:0007062; P:sister chromatid cohesion; IMP:TAIR.
DR Gene3D; 1.10.10.580; -; 1.
DR InterPro; IPR039781; Rad21/Rec8-like.
DR InterPro; IPR006909; Rad21/Rec8_C_eu.
DR InterPro; IPR006910; Rad21_Rec8_N.
DR InterPro; IPR023093; ScpA-like_C.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12585; PTHR12585; 1.
DR Pfam; PF04824; Rad21_Rec8; 1.
DR Pfam; PF04825; Rad21_Rec8_N; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 2: Evidence at transcript level;
KW Alternative promoter usage; Cell cycle; Chromosome partition; Meiosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..627
FT /note="Sister chromatid cohesion 1 protein 1"
FT /id="PRO_0000097875"
FT REGION 211..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..16
FT /note="MLRLESLIVTVWGPAT -> MFYSHQ (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:10072401,
FT ECO:0000303|PubMed:10504568"
FT /id="VSP_007492"
SQ SEQUENCE 627 AA; 71228 MW; 05D815E914233650 CRC64;
MLRLESLIVT VWGPATLLAR KAPLGQIWMA ATLHAKINRK KLDKLDIIQI CEEILNPSVP
MALRLSGILM GGVVIVYERK VKLLFDDVNR FLVEINGAWR TKSVPDPTLL PKGKTHARKE
AVTLPENEEA DFGDFEQTRN VPKFGNYMDF QQTFISMRLD ESHVNNNPEP EDLGQQFHQA
DAENITLFEY HGSFQTNNET YDRFERFDIE GDDETQMNSN PREGAEIPTT LIPSPPRHHD
IPEGVNPTSP QRQEQQENRR DGFAEQMEEQ NIPDKEEHDR PQPAKKRARK TATSAMDYEQ
TIIAGHVYQS WLQDTSDILC RGEKRKVRGT IRPDMESFKR ANMPPTQLFE KDSSYPPQLY
QLWSKNTQVL QTSSSESRHP DLRAEQSPGF VQERMHNHHQ TDHHERSDTS SQNLDSPAEI
LRTVRTGKGA SVESMMAGSR ASPETINRQA ADINVTPFYS GDDVRSMPST PSARGAASIN
NIEISSKSRM PNRKRPNSSP RRGLEPVAEE RPWEHREYEF EFSMLPEKRF TADKEILFET
ASTQTQKPVC NQSDEMITDS IKSHLKTHFE TPGAPQVESL NKLAVGMDRN AAAKLFFQSC
VLATRGVIKV NQAEPYGDIL IARGPNM
