SCC13_ARATH
ID SCC13_ARATH Reviewed; 693 AA.
AC Q9FQ19; Q9M1B3;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Sister chromatid cohesion 1 protein 3;
DE AltName: Full=SCC1 homolog 3;
DE Short=AtRAD21-2;
GN Name=SYN3; OrderedLocusNames=At3g59550; ORFNames=T16L24.100;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
RC STRAIN=cv. Wassilewskija;
RX PubMed=11410371; DOI=10.1016/s0378-1119(01)00499-1;
RA Dong F., Cai X., Makaroff C.A.;
RT "Cloning and characterization of two Arabidopsis genes that belong to the
RT RAD21/REC8 family of chromosome cohesin proteins.";
RL Gene 271:99-108(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. Columbia;
RA Costa-Nunes J.A., Bhatt A.M., Dickinson H.G.;
RT "Functional analysis of the three Arabidopsis RAD21 homologs.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: May be involved in sister chromatid cohesion during mitosis.
CC -!- SUBUNIT: Component of the cohesin complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9FQ19-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FQ19-2; Sequence=VSP_007494, VSP_007495;
CC Name=3;
CC IsoId=Q9FQ19-3; Sequence=VSP_007496;
CC -!- TISSUE SPECIFICITY: Low expression in shoots, buds, siliques, leaves
CC and roots. Found in, but not limited to, actively dividing cells: in
CC procambium, protoderm and ground meristem in roots, and in shoot and
CC floral meristems.
CC -!- MISCELLANEOUS: [Isoform 2]: Derived from PCR data. Produced by intron
CC retention. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: Derived from PCR data. Produced by intron
CC retention. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the rad21 family. {ECO:0000305}.
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DR EMBL; AF281155; AAG44843.1; -; mRNA.
DR EMBL; AF400128; AAL62059.1; -; mRNA.
DR EMBL; AL138659; CAB75452.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79939.1; -; Genomic_DNA.
DR PIR; T49296; T49296.
DR RefSeq; NP_191514.1; NM_115817.3. [Q9FQ19-1]
DR AlphaFoldDB; Q9FQ19; -.
DR SMR; Q9FQ19; -.
DR STRING; 3702.AT3G59550.1; -.
DR iPTMnet; Q9FQ19; -.
DR PaxDb; Q9FQ19; -.
DR PRIDE; Q9FQ19; -.
DR ProteomicsDB; 232842; -. [Q9FQ19-1]
DR EnsemblPlants; AT3G59550.1; AT3G59550.1; AT3G59550. [Q9FQ19-1]
DR GeneID; 825124; -.
DR Gramene; AT3G59550.1; AT3G59550.1; AT3G59550. [Q9FQ19-1]
DR KEGG; ath:AT3G59550; -.
DR Araport; AT3G59550; -.
DR TAIR; locus:2097548; AT3G59550.
DR eggNOG; KOG1213; Eukaryota.
DR HOGENOM; CLU_018792_0_0_1; -.
DR InParanoid; Q9FQ19; -.
DR OMA; QQEEPYG; -.
DR OrthoDB; 171779at2759; -.
DR PhylomeDB; Q9FQ19; -.
DR PRO; PR:Q9FQ19; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9FQ19; baseline and differential.
DR Genevisible; Q9FQ19; AT.
DR GO; GO:0008278; C:cohesin complex; IBA:GO_Central.
DR GO; GO:0000798; C:nuclear cohesin complex; ISS:TAIR.
DR GO; GO:0005730; C:nucleolus; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; ISS:TAIR.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0009561; P:megagametogenesis; IMP:TAIR.
DR GO; GO:0000278; P:mitotic cell cycle; IEP:TAIR.
DR GO; GO:0009555; P:pollen development; IMP:TAIR.
DR GO; GO:1990414; P:replication-born double-strand break repair via sister chromatid exchange; IBA:GO_Central.
DR GO; GO:0007062; P:sister chromatid cohesion; IBA:GO_Central.
DR Gene3D; 1.10.10.580; -; 1.
DR InterPro; IPR039781; Rad21/Rec8-like.
DR InterPro; IPR006909; Rad21/Rec8_C_eu.
DR InterPro; IPR006910; Rad21_Rec8_N.
DR InterPro; IPR023093; ScpA-like_C.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12585; PTHR12585; 1.
DR Pfam; PF04824; Rad21_Rec8; 1.
DR Pfam; PF04825; Rad21_Rec8_N; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell cycle; Cell division; Chromosome partition;
KW Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..693
FT /note="Sister chromatid cohesion 1 protein 3"
FT /id="PRO_0000097877"
FT REGION 167..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 334..338
FT /note="VHPSP -> GELAT (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_007494"
FT VAR_SEQ 339..693
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_007495"
FT VAR_SEQ 660
FT /note="L -> LVSDSLYICFSLYLCSASSLDELFLNLQ (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_007496"
FT CONFLICT 179
FT /note="S -> R (in Ref. 1; AAG44843)"
FT /evidence="ECO:0000305"
FT CONFLICT 346
FT /note="Missing (in Ref. 1; AAG44843)"
FT /evidence="ECO:0000305"
FT CONFLICT 481
FT /note="Q -> K (in Ref. 1; AAG44843)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 693 AA; 77141 MW; 757B9248A62F990B CRC64;
MFYSHTLLAR KGPLGTVWCA AHVHQRLKKS QYTSINIPDT VDNIMFPEVP LALRTSSHLL
VGVVRIYSKK VDYLYNDWNL LNTWVAKAFV STQVNLPEDA RQAPPESVTL PQALNLDEFD
LEDDTLDMEF DNHTRSEEDI TLTDQIPTGI DPYVAVTFDE DIISESIPMD VDQSTEPVSR
HTGEIDVETA HETGPDNEPR DSNIAFDTGT YSPRNVTEEF TEVQDPRQSN LTEERIPNSE
RNDATSPGTV PEIERMRDAA HDLSPTSHPS FAAQQQDVRV ERTESLDETL NEKEPTIPSI
DEEMLNSGRH SAFELRSGSP GSAAGSEEER ADFVHPSPQL VLQPSPPPQP QRRARKRKNF
DGVTVLTNKN ISERLKDPSD TLRKRKKMPS SKLKFWRMNN QSRKDQNFNE PLFTGFSDDL
RNVFEKDYVA SKPHLAVSDE TLPEPASVSP TREAEVEINP VSPIPDSTNP DSTVQLSPAQ
QTEDVLDSAG PRPAHAESVA TEAQSPRTFD NDDMGIEHLR DGGFPVYMPS PPPRSSPFRT
DDFTTQSGNW ETESYRTEPS TSTVPEDLPG QRNLGLSPVS ERTDEELYFL EVGGNSPVGT
PASQDSAALT GRARALAQYL KQRSSSSPTT SSHPSGDLSL SEILAGKTRK LAARMFFETL
VLKSRGLIDM QQDRPYGDIA LKLMPALFSK VQT
