SCC2_ASHGO
ID SCC2_ASHGO Reviewed; 1479 AA.
AC Q750S2;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Sister chromatid cohesion protein 2;
GN Name=SCC2; OrderedLocusNames=AGL133W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Plays a structural role in chromatin. Probably involved in
CC sister chromatid cohesion, possibly by interacting with the cohesin
CC complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SCC2/Nipped-B family. {ECO:0000305}.
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DR EMBL; AE016820; AAS54358.1; -; Genomic_DNA.
DR RefSeq; NP_986534.1; NM_211596.1.
DR PDB; 5C6G; X-ray; 2.60 A; B/D=1-218.
DR PDB; 5ME3; X-ray; 2.85 A; A/B=378-1479.
DR PDBsum; 5C6G; -.
DR PDBsum; 5ME3; -.
DR AlphaFoldDB; Q750S2; -.
DR SMR; Q750S2; -.
DR STRING; 33169.AAS54358; -.
DR EnsemblFungi; AAS54358; AAS54358; AGOS_AGL133W.
DR GeneID; 4622833; -.
DR KEGG; ago:AGOS_AGL133W; -.
DR eggNOG; KOG1020; Eukaryota.
DR HOGENOM; CLU_259053_0_0_1; -.
DR InParanoid; Q750S2; -.
DR OMA; YVTKCLL; -.
DR Proteomes; UP000000591; Chromosome VII.
DR GO; GO:0005729; C:2-micrometer circle DNA; IEA:EnsemblFungi.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0090694; C:Scc2-Scc4 cohesin loading complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0043515; F:kinetochore binding; IEA:EnsemblFungi.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:EnsemblFungi.
DR GO; GO:0034087; P:establishment of mitotic sister chromatid cohesion; IBA:GO_Central.
DR GO; GO:0071169; P:establishment of protein localization to chromatin; IBA:GO_Central.
DR GO; GO:0007076; P:mitotic chromosome condensation; IEA:EnsemblFungi.
DR GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR GO; GO:1905309; P:positive regulation of cohesin loading; IEA:EnsemblFungi.
DR GO; GO:0070550; P:rDNA chromatin condensation; IEA:EnsemblFungi.
DR GO; GO:0010468; P:regulation of gene expression; IEA:EnsemblFungi.
DR GO; GO:1990414; P:replication-born double-strand break repair via sister chromatid exchange; IBA:GO_Central.
DR GO; GO:0000972; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0070058; P:tRNA gene clustering; IEA:EnsemblFungi.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026003; Cohesin_HEAT.
DR InterPro; IPR024986; Nipped-B_C.
DR InterPro; IPR033031; Scc2/Nipped-B.
DR PANTHER; PTHR21704; PTHR21704; 1.
DR Pfam; PF12765; Cohesin_HEAT; 1.
DR Pfam; PF12830; Nipped-B_C; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..1479
FT /note="Sister chromatid cohesion protein 2"
FT /id="PRO_0000218602"
FT REPEAT 681..718
FT /note="HEAT 1"
FT REPEAT 720..757
FT /note="HEAT 2"
FT REPEAT 792..829
FT /note="HEAT 3"
FT REPEAT 1117..1154
FT /note="HEAT 4"
FT REPEAT 1229..1266
FT /note="HEAT 5"
FT TURN 5..8
FT /evidence="ECO:0007829|PDB:5C6G"
FT STRAND 9..11
FT /evidence="ECO:0007829|PDB:5C6G"
FT HELIX 15..19
FT /evidence="ECO:0007829|PDB:5C6G"
FT HELIX 31..35
FT /evidence="ECO:0007829|PDB:5C6G"
FT STRAND 41..47
FT /evidence="ECO:0007829|PDB:5C6G"
FT HELIX 58..62
FT /evidence="ECO:0007829|PDB:5C6G"
FT HELIX 99..101
FT /evidence="ECO:0007829|PDB:5C6G"
FT STRAND 102..104
FT /evidence="ECO:0007829|PDB:5C6G"
FT HELIX 107..112
FT /evidence="ECO:0007829|PDB:5C6G"
FT TURN 113..115
FT /evidence="ECO:0007829|PDB:5C6G"
FT HELIX 121..123
FT /evidence="ECO:0007829|PDB:5C6G"
FT STRAND 124..126
FT /evidence="ECO:0007829|PDB:5C6G"
FT STRAND 424..427
FT /evidence="ECO:0007829|PDB:5ME3"
FT TURN 428..430
FT /evidence="ECO:0007829|PDB:5ME3"
FT STRAND 431..434
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 435..444
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 450..455
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 461..493
FT /evidence="ECO:0007829|PDB:5ME3"
FT TURN 497..499
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 501..514
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 523..535
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 546..568
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 579..583
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 586..602
FT /evidence="ECO:0007829|PDB:5ME3"
FT STRAND 605..607
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 609..627
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 639..649
FT /evidence="ECO:0007829|PDB:5ME3"
FT TURN 664..666
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 667..674
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 678..681
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 683..692
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 693..695
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 699..715
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 717..721
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 723..734
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 738..749
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 755..757
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 758..761
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 762..764
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 770..786
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 790..802
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 809..823
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 825..828
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 834..852
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 856..868
FT /evidence="ECO:0007829|PDB:5ME3"
FT TURN 869..871
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 873..875
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 878..902
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 914..926
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 935..941
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 943..946
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 953..965
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 973..986
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 992..1009
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1013..1024
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1027..1034
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1045..1059
FT /evidence="ECO:0007829|PDB:5ME3"
FT STRAND 1073..1076
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1078..1088
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1096..1112
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1114..1118
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1120..1132
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1135..1156
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1187..1205
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1210..1226
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1231..1233
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1235..1241
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1247..1263
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1265..1270
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1272..1286
FT /evidence="ECO:0007829|PDB:5ME3"
FT TURN 1288..1290
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1291..1293
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1297..1305
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1309..1326
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1334..1350
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1356..1378
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1381..1383
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1386..1388
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1391..1414
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1419..1423
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1433..1436
FT /evidence="ECO:0007829|PDB:5ME3"
FT STRAND 1437..1440
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1451..1454
FT /evidence="ECO:0007829|PDB:5ME3"
FT HELIX 1464..1472
FT /evidence="ECO:0007829|PDB:5ME3"
SQ SEQUENCE 1479 AA; 170017 MW; 5DA48A04CA8E4D3D CRC64;
MSTFPGEDTR IPKRISEALS HQPLNHLVPK RELSRLLSKP VQISVQLESE DAFEEVPEEL
WQYPHPIDLD PLRLEESQPL RFRRPRGARL DYREDSSEIA DLPGMGQLAR ACLSGTQLVD
SAAIVESIES NAKKRKQTLA IGDVEMVSPD KKTKVMASVS PVSLNRVALG SQHLKTLERL
MQYIGADESS AEFGDFEYWI TLEDRATHIL SEQCIDKLHI VFRNILSIPA VWTELDVSLL
QRIMDVCVST ITICLEKIEL KEYSHDYTLI AFGSSMVVFF IFLLDQNDRR LQLEQYMMVP
LQFLTFTADN LEEEFDRGGN GVERSLAMLH STLDVFYMYI SNKPKLDDGL VVKLVYMFTE
LIMSTWSHNV SSVSLQNHIG NVKTIGMKSI EVLFEKLPEQ RLFIIDELLS HLDNLPNTRS
QKRMKNIGKN LHITHFSYIM LSILQVWNNY DYCSNLVSPD TEQLHDLIAH HAATQSDLEF
AADHIIDTIL KKCFSNISKY RFVFDQFVTD MTTVVTLPDW PVSDLILARL LKKLLSIFNP
QSQKHINIES VALQGIGLIG STILDIRLSS NSNPTANLIH LFNYPEDIDG LFKAYRTCLA
YCTNSVQHHT PYKFLWCKQL DVLTKLKEMD KESQGWGSKL QQKFLSLIES IHLPLEQAAN
LGAVEILPTY CSTLLTSELI NMYEPYLKLV LSLLERHKVK LRSGAIRCLA LLISKDKNML
YTPIVKETIE NRLTDSSPLV KDAILELIEL GSSYIDFYQH ININYNDDSM LVRKHVLRMN
QIIYDDTEDI IIKAYVASRI LRRIEDEEDV IIETARSELL KRWILSIQCP NAKPELQIKN
CRVSIRVIAQ LLVGGDKICD LFEHFLIFYV LNKNAHTEDQ NKLISSSLCL LTDQVIEMVI
ENEAADVDNQ REEEGRNIMK FLSVLSSCQD SFITKDHITA LYPYLHSDTK SDFQLHILKV
YRNTFEQLSH FKPKFLYDLE TTILSRLPRM NVRELDEAIP LSWSLSRHRK DDTRICKACA
SCLGQLSPYI ANATTDPSAV RPDGKLQRLL YLATGFARFC SFENTEGKFP NLKTRENIFE
YVTKCLLMFT KENIHHVIRR IATKNLVKIA SRYPKLFNSR HVLTVLDTQF EKGILDIQLV
VLESLYDFFL AEERRSLIQV GVDGTISSNN ELRKVVANHT KSDSINDGIC SALVSRYLDK
ILKICLIADL NNAMVAIRFL KQILTYGYTN PSLCVPTVIA LTASPNSYMR DLSSEMFSEL
LQGYESMAFN CLNQGIRLGT EYAVKIRPKQ FHEDSMFLRR LQQLMSTNKR NRSKFLKVVK
KTVFSNYLST SVNYEESCYH IIYLLHNLSK ISYDNMLELY EMLRSVISVS EYFSDRISER
LDGFQSNQNT AAEVSAIIVT RLSIEEFKRF MFEQHHLSEA KLTLLDATDD ENLRNKSVAA
LDDQVGSLHM ENIFLGYENP INNKDYCWKY ISTLHRDEI
