ID   SCC4_AEDAE              Reviewed;         620 AA.
AC   Q16NZ8;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=MAU2 chromatid cohesion factor homolog;
DE   AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN   ORFNames=AAEL011819;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Required for association of the cohesin complex with
CC       chromatin during interphase. Plays a role in sister chromatid cohesion
CC       and normal progression through prometaphase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the cohesin loading complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Note=Binds to
CC       chromatin from the end of mitosis until prophase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR   EMBL; CH477801; EAT36076.1; -; Genomic_DNA.
DR   RefSeq; XP_001661928.1; XM_001661878.1.
DR   AlphaFoldDB; Q16NZ8; -.
DR   STRING; 7159.AAEL011819-PA; -.
DR   GeneID; 5575408; -.
DR   KEGG; aag:5575408; -.
DR   VEuPathDB; VectorBase:AAEL011819; -.
DR   eggNOG; KOG2300; Eukaryota.
DR   HOGENOM; CLU_030238_0_0_1; -.
DR   InParanoid; Q16NZ8; -.
DR   OMA; SSQDAWY; -.
DR   OrthoDB; 240898at2759; -.
DR   PhylomeDB; Q16NZ8; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR019440; MAU2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR21394; PTHR21394; 1.
DR   Pfam; PF10345; Cohesin_load; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..620
FT                   /note="MAU2 chromatid cohesion factor homolog"
FT                   /id="PRO_0000382727"
FT   REPEAT          90..123
FT                   /note="TPR 1"
FT   REPEAT          445..478
FT                   /note="TPR 2"
FT   REPEAT          485..518
FT                   /note="TPR 3"
SQ   SEQUENCE   620 AA;  70629 MW;  3EBC903EC564F799 CRC64;
     MTSSQDACYI SLLGLAEYFR TSSPPNIKKC IQCLQALFTF KPPLKVEART HLQLGQILMA
     YTKNTDLARN HLEQAWMLSE NINNFDDVKF DTASLLAQLY QQQEQSSLAK PVLRKAIELS
     QHNVYWHCKL LFQLAQTHAT DKEYALASEL LAVGVESTDE TNATYLKTLF LLSRAMIMMI
     ERKTGDVLTI LNQAGTMIDN AVQNIHLKEY LKVFFYVLQV CHYLQLGQVK TVKTSLKQLQ
     QSIQTIMAPN WPADEQIFGQ SNTEMFMWLP KEQLYVLVYL VTVSHSMMAG YMDKAQKYTE
     KALTQIEKLK SQENKPILAV FQIILLEHII MCRLVMGNKS LAIKEIALAK DVCLSSSNKF
     LLKKHSAQLH CLLGLYAMSA SYFEHAERQF FACINDTTER DLKLFANLNL AIVYLRMKRE
     QELRQILDQV QQENSQCSNS QALMGSFYYV QGLNAFHKSS FHEAKRFLRE TLKMANAEDL
     NRLTSCSLVL LSHVFLSIGN SKESMNMVTP AMQLASKIPD IHVQLWGSAI LKDLHRMLKE
     PALETEAYNN HCNFSQNLIA DQMKCTKFPE HTLISWVQGD PPLPMLSQEI LEAPPAATIQ
     QQSATVVRLS GQPGQQVIYQ