SCC4_ARATH
ID SCC4_ARATH Reviewed; 726 AA.
AC Q9FGN7; Q0WPL4;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Sister chromatid cohesion protein SCC4 {ECO:0000303|PubMed:28137757};
DE AltName: Full=Protein SISTER-CHROMATID COHESION 4 {ECO:0000303|PubMed:28137757};
DE Short=AtSCC4 {ECO:0000303|PubMed:28137757};
GN Name=SCC4 {ECO:0000303|PubMed:28137757};
GN OrderedLocusNames=At5g51340 {ECO:0000312|Araport:AT5G51340};
GN ORFNames=MFG13.4 {ECO:0000312|EMBL:BAB09745.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND INTERACTION WITH
RP SCC2.
RC STRAIN=cv. Columbia;
RX PubMed=28137757; DOI=10.1242/jcs.196865;
RA Minina E.A., Reza S.H., Gutierrez-Beltran E., Elander P.H., Bozhkov P.V.,
RA Moschou P.N.;
RT "The Arabidopsis homolog of Scc4/MAU2 is essential for embryogenesis.";
RL J. Cell Sci. 130:1051-1063(2017).
CC -!- FUNCTION: Essential protein required for cell fate determination during
CC embryogenesis. Involved in sister chromatid cohesion. Forms a complex
CC with SCC2, which is required for the association of the cohesin complex
CC with chromosomes. {ECO:0000269|PubMed:28137757}.
CC -!- SUBUNIT: Interacts with SCC2 to form the cohesin loading complex.
CC {ECO:0000269|PubMed:28137757}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28137757}. Cytoplasm
CC {ECO:0000269|PubMed:28137757}. Note=Associates with chromatin,
CC especially during telophase, prophase and interphase. Mostly localized
CC in the nucleus during interphase and preprophase stages, but not in the
CC nucleolus. During prometaphase, metaphase, anaphase and telophase,
CC mostly cytoplasmic. {ECO:0000269|PubMed:28137757}.
CC -!- TISSUE SPECIFICITY: Expressed ubiquitously.
CC {ECO:0000269|PubMed:28137757}.
CC -!- DISRUPTION PHENOTYPE: Defective embryo arrested at preglobular/early
CC globular stage. Suspensor overproliferation phenotype preceded by
CC ectopic auxin maxima distribution. Reduced efficacy of cohesin
CC immobilization in nuclei. {ECO:0000269|PubMed:28137757}.
CC -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR EMBL; AB025621; BAB09745.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96068.1; -; Genomic_DNA.
DR EMBL; AK229053; BAF00935.1; -; mRNA.
DR RefSeq; NP_199947.1; NM_124513.3.
DR AlphaFoldDB; Q9FGN7; -.
DR STRING; 3702.AT5G51340.1; -.
DR PaxDb; Q9FGN7; -.
DR PRIDE; Q9FGN7; -.
DR ProteomicsDB; 232915; -.
DR EnsemblPlants; AT5G51340.1; AT5G51340.1; AT5G51340.
DR GeneID; 835208; -.
DR Gramene; AT5G51340.1; AT5G51340.1; AT5G51340.
DR KEGG; ath:AT5G51340; -.
DR Araport; AT5G51340; -.
DR TAIR; locus:2163655; AT5G51340.
DR eggNOG; KOG2300; Eukaryota.
DR HOGENOM; CLU_027111_0_0_1; -.
DR InParanoid; Q9FGN7; -.
DR OMA; SSQDAWY; -.
DR OrthoDB; 240898at2759; -.
DR PhylomeDB; Q9FGN7; -.
DR PRO; PR:Q9FGN7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FGN7; baseline and differential.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0032116; C:SMC loading complex; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR019440; MAU2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR21394; PTHR21394; 1.
DR Pfam; PF10345; Cohesin_load; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Chromosome partition; Cytoplasm; Mitosis;
KW Nucleus; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..726
FT /note="Sister chromatid cohesion protein SCC4"
FT /id="PRO_0000440651"
FT REPEAT 7..40
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 88..121
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REPEAT 132..165
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT REPEAT 229..262
FT /note="TPR 4"
FT /evidence="ECO:0000255"
FT REPEAT 443..477
FT /note="TPR 5"
FT /evidence="ECO:0000255"
FT REPEAT 531..564
FT /note="TPR 6"
FT /evidence="ECO:0000255"
FT REPEAT 572..605
FT /note="TPR 7"
FT /evidence="ECO:0000255"
FT REGION 697..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 437
FT /note="N -> K (in Ref. 3; BAF00935)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 726 AA; 81880 MW; 74F3A6F3EC3ABBCD CRC64;
MEGAAVAEGL WGLADHHQKL GEIGKTIKCL EAICQSQISF LPLVEVKSRL RLAALLLRYS
HNVNHAKSHL ERSLLLLKSI PSSYDLKFQN YSLLSHCYHL LASFPPQRNL LVKALELASS
VPQDISAYLW SCNFNSQLAN TFIIQADFPS SLSALESGFL SASHICFPEL QMFFTASMLH
VHIMQWTDDY SVEKAVQRCD EIWQTISSDK TDRCPGLFFY NEMLHVFYRL RLCDYKNAQH
HVDRLDQAMN AHSHKMQEIQ QLLDELSSLN LSLSRYDLPS RERSALSARQ SQLQDRVNAL
SPSSSTVNSL EPAYFGNIDR GWTEKLLLSP SPIDGEWLPK SAIDALVHLM VVISGRPKGL
FKECSKRIES GLQIIQDELI KLGITDEVRE ADLRHTAIWM SRVFLMLQMQ FLENRVALEL
TRSDYVEAEE ALVDMKNWFT RFPTILQASE CMIEMLRGQY SHSVGCYSEA AFHCIEATKL
TESISMQASC QAFAAVSYLT IGDAESSSKA LDLIGPLNGM TNSLSGVREE ASILFAYGLL
LMKQRDLQEA RNRLAKGLQI AHNHMGNLQL VAQYLTLLGN LALSLHDTVQ AREILRSSLT
LAKKLYDIPT QLWVLSIFTA LYQQLGEKGN EMENEEFRKK KWDELQSRLA EARGSIHHIE
LVAKARIELY QIDNNPQEQS LVASAQSMQG NLDIPESVGI EGPSPAPSSS RLVGLDTGKR
WGKRRM
