SCC4_CAEEL
ID SCC4_CAEEL Reviewed; 593 AA.
AC O17581;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Maternal uncoordinated protein 2;
DE AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN Name=mau-2 {ECO:0000312|WormBase:C09H6.3};
GN ORFNames=C09H6.3 {ECO:0000312|WormBase:C09H6.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP DISRUPTION PHENOTYPE.
RX PubMed=8601479; DOI=10.1093/genetics/141.4.1351;
RA Hekimi S., Boutis P., Lakowski B.;
RT "Viable maternal-effect mutations that affect the development of the
RT nematode Caenorhabditis elegans.";
RL Genetics 141:1351-1364(1995).
RN [3]
RP DISRUPTION PHENOTYPE.
RX PubMed=9362469; DOI=10.1242/dev.124.24.5115;
RA Takagi S., Benard C., Pak J., Livingstone D., Hekimi S.;
RT "Cellular and axonal migrations are misguided along both body axes in the
RT maternal-effect mau-2 mutants of Caenorhabditis elegans.";
RL Development 124:5115-5126(1997).
RN [4]
RP FUNCTION, DEVELOPMENTAL STAGE, AND SUBCELLULAR LOCATION.
RX PubMed=15539489; DOI=10.1242/dev.01433;
RA Benard C.Y., Kebir H., Takagi S., Hekimi S.;
RT "mau-2 acts cell-autonomously to guide axonal migrations in Caenorhabditis
RT elegans.";
RL Development 131:5947-5958(2004).
CC -!- FUNCTION: Plays an important role in the loading of the cohesin complex
CC on to DNA (By similarity). Forms a heterodimeric complex (also known as
CC cohesin loading complex) with scc-2/SCC2 which mediates the loading of
CC the cohesin complex onto chromatin (By similarity). Required for normal
CC development until the fourth larval stage. Functions cell autonomously
CC to guide migrations during the development of the nervous system.
CC Participates in the guidance of mechanosensory neuron AVM by a slt-1-
CC independent mechanism. Regulates chromosome segregation in early
CC embryos. {ECO:0000250|UniProtKB:Q9Y6X3, ECO:0000269|PubMed:15539489}.
CC -!- SUBUNIT: May heterodimerize with scc-2/SCC2 to form the cohesin loading
CC complex. {ECO:0000250|UniProtKB:Q9Y6X3}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000269|PubMed:15539489}. Cytoplasm {ECO:0000269|PubMed:15539489}.
CC Note=Binds to chromatin from the end of mitosis until prophase.
CC Localizes to the cytoplasm of neurons.
CC -!- DEVELOPMENTAL STAGE: Ubiquitously expressed in embryos by late
CC gastrulation. Becomes predominantly expressed in the nervous system as
CC morphogenesis progresses. {ECO:0000269|PubMed:15539489}.
CC -!- DISRUPTION PHENOTYPE: Chromosomal, neuroanatomical, guidance and egg-
CC laying defects. Altering the activity of both the dorsal repellent slt-
CC 1 and mau-2 leads to the abnormal dorsal projection of the AVM axon.
CC Migrating cells and axons are mispositioned along both the antero-
CC posterior and dorsoventral body axes. {ECO:0000269|PubMed:8601479,
CC ECO:0000269|PubMed:9362469}.
CC -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284601; CAB03867.1; -; Genomic_DNA.
DR PIR; T19169; T19169.
DR RefSeq; NP_492228.1; NM_059827.4.
DR AlphaFoldDB; O17581; -.
DR BioGRID; 38032; 3.
DR STRING; 6239.C09H6.3; -.
DR EPD; O17581; -.
DR PaxDb; O17581; -.
DR PeptideAtlas; O17581; -.
DR PRIDE; O17581; -.
DR EnsemblMetazoa; C09H6.3.1; C09H6.3.1; WBGene00003136.
DR GeneID; 172598; -.
DR KEGG; cel:CELE_C09H6.3; -.
DR CTD; 172598; -.
DR WormBase; C09H6.3; CE15611; WBGene00003136; mau-2.
DR eggNOG; KOG2300; Eukaryota.
DR GeneTree; ENSGT00390000012198; -.
DR HOGENOM; CLU_030238_0_0_1; -.
DR InParanoid; O17581; -.
DR OMA; MELYFRI; -.
DR OrthoDB; 1283106at2759; -.
DR PhylomeDB; O17581; -.
DR Reactome; R-CEL-2470946; Cohesin Loading onto Chromatin.
DR PRO; PR:O17581; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00003136; Expressed in embryo and 4 other tissues.
DR GO; GO:0030424; C:axon; IDA:WormBase.
DR GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0033564; P:anterior/posterior axon guidance; IMP:WormBase.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0033563; P:dorsal/ventral axon guidance; IMP:WormBase.
DR GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR GO; GO:0018991; P:oviposition; IMP:WormBase.
DR InterPro; IPR019440; MAU2.
DR PANTHER; PTHR21394; PTHR21394; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW Developmental protein; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..593
FT /note="Maternal uncoordinated protein 2"
FT /id="PRO_0000382726"
SQ SEQUENCE 593 AA; 67867 MW; 048EBB6469D65202 CRC64;
MNQDAVAKAL LGMAEALRTQ DPPKLKMAIK CARSTLSMEI SDEMKAICNL QLGKLLFFYT
DNFELAKNHL QCAYDKMSAM GTFYTRDKMN AISMLADLHI HYQQWPLTSI KATIRHEITT
TRGFPALSNK LMFQLIELMK IDKDVEGAIE MCQLAINSSH ADPKMELYFR IAKTLVTYQL
MHEEPDISDV TRIGSMIKVM ENSTTSDKAH LECIKDFYVC TKLAYMFYEG KSRTSRQLLR
QIQKSQTSGE TKIHGIRWLG EPSITLLACV MNQICALVQS NTDRVEKYYH LVIKHADEII
FKSTRSPQEP GVVRCINMIK MTTLEMMACC NVLACRPQKT LHNVRDMLEW SNRTSGPLLT
RYFTPHIHYI LGLQCCYFRQ HENAENHFRA AMKKLHKEDI TAHNTMALLN LNLAITYLNQ
LKMADYYEVS ENLTAPKISS CSQMLKNNVK LLSAFFAYIT NKLNECKLLS HEVLDDSKAE
DFFRLHGLGL LLLSLVTDVD EKGVRPTVDW SKKSHDHVVI LFSHSLYEKI LLAAGYDPKS
ELMKMVVSEQ LASRRMLSVE NLTPLVANMP ASKLLQWFDG DPFKLLPRDE TVL
