ID   SCC4_CULQU              Reviewed;         616 AA.
AC   B0WYS3;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=MAU2 chromatid cohesion factor homolog;
DE   AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN   ORFNames=CPIJ012302;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for association of the cohesin complex with
CC       chromatin during interphase. Plays a role in sister chromatid cohesion
CC       and normal progression through prometaphase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the cohesin loading complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Note=Binds to
CC       chromatin from the end of mitosis until prophase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR   EMBL; DS232197; EDS37183.1; -; Genomic_DNA.
DR   RefSeq; XP_001862545.1; XM_001862510.1.
DR   AlphaFoldDB; B0WYS3; -.
DR   STRING; 7176.CPIJ012302-PA; -.
DR   EnsemblMetazoa; XM_001862510.2; XP_001862545.1; LOC6045145.
DR   GeneID; 6045145; -.
DR   KEGG; cqu:CpipJ_CPIJ012302; -.
DR   VEuPathDB; VectorBase:CPIJ012302; -.
DR   VEuPathDB; VectorBase:CQUJHB003871; -.
DR   eggNOG; KOG2300; Eukaryota.
DR   HOGENOM; CLU_030238_0_0_1; -.
DR   InParanoid; B0WYS3; -.
DR   OMA; SSQDAWY; -.
DR   OrthoDB; 240898at2759; -.
DR   PhylomeDB; B0WYS3; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR019440; MAU2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR21394; PTHR21394; 1.
DR   Pfam; PF10345; Cohesin_load; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..616
FT                   /note="MAU2 chromatid cohesion factor homolog"
FT                   /id="PRO_0000382728"
FT   REPEAT          90..123
FT                   /note="TPR 1"
FT   REPEAT          445..478
FT                   /note="TPR 2"
FT   REPEAT          485..518
FT                   /note="TPR 3"
SQ   SEQUENCE   616 AA;  70131 MW;  B17AE74E8C42B575 CRC64;
     MTSSQDACYI SLLGLAEYFR TSSPPNIKKC IQCLQALFTF KPPLKVEART HLQLGQILMA
     YTKNTELARN HLEQAWMLSE NINNFDDVKF DTASLLAQLY QQQEQSSLAK PVLRKAIELS
     QHNVYWHCKL LFQLAQTHAT DKEYALASEL LAVGVESTDE SNATYLKSLF LLSRAMIMMI
     ERKSSDVLAI LNQAGTIIDN AIQNIHLKEY LKVFFFVLQV CHYLQLGQVK TVKTSLKQLQ
     QSIQTIMAPN WPSDEQIFGQ NSTEMFMWLP KEQLYVLVYL VTVSHSMMAG YMDKAQKYTE
     KALTQIEKLK SQENKPILAV FQIILLEHII MCRLVMGNKS LAIKEIALAK DVCLSSSHKF
     LLKKHSPQLH CLLGLYSMSA SLFDHAERQF YTCIQETTER DLKLFANLNL AIVYLRMKRE
     PDLRAILDQV QQENSLCSNS QALMGSFYYV QGLNAFHKSS FHEAKRFLRE TLKMANAEDL
     NRLTSCSLVL LSHVFLSIGN SKESMNMVTP AMQLASKIPD IHVQLWGSAI LKDLHRMLKE
     PALEQEAYNN HLNFSQNLIA DQLKCTKFQE HTLINWIQGD PPMPMLTTQE PMMGEPSQAA
     AMRVAAGAPG QQVIFQ