ID   SCC4_DROAN              Reviewed;         639 AA.
AC   B3M1B7;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=MAU2 chromatid cohesion factor homolog;
DE   AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN   ORFNames=GF17837;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for association of the cohesin complex with
CC       chromatin during interphase. Plays a role in sister chromatid cohesion
CC       and normal progression through prometaphase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with Nipped-B to form the cohesin loading complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Note=Binds to
CC       chromatin from the end of mitosis until prophase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR   EMBL; CH902617; EDV42144.1; -; Genomic_DNA.
DR   RefSeq; XP_001953583.1; XM_001953547.2.
DR   AlphaFoldDB; B3M1B7; -.
DR   STRING; 7217.FBpp0121029; -.
DR   EnsemblMetazoa; FBtr0122537; FBpp0121029; FBgn0094855.
DR   GeneID; 6500620; -.
DR   KEGG; dan:6500620; -.
DR   eggNOG; KOG2300; Eukaryota.
DR   HOGENOM; CLU_030238_0_0_1; -.
DR   InParanoid; B3M1B7; -.
DR   OMA; SSQDAWY; -.
DR   OrthoDB; 240898at2759; -.
DR   PhylomeDB; B3M1B7; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR019440; MAU2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR21394; PTHR21394; 1.
DR   Pfam; PF10345; Cohesin_load; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..639
FT                   /note="MAU2 chromatid cohesion factor homolog"
FT                   /id="PRO_0000382729"
FT   REPEAT          453..486
FT                   /note="TPR 1"
FT   REPEAT          493..526
FT                   /note="TPR 2"
SQ   SEQUENCE   639 AA;  71840 MW;  28372873688ADD12 CRC64;
     MSASTSTTAA ASQDACYISL LGLAEYFRTS QPPNIKKCIQ CLQALFTFMP PSKVEARTHL
     QMGQILMAYT QNIDLARHHL EKAWSISEPL ANFDVKFDTA SLLAQLHLQT DQNSNQAKAM
     LRRAVELSQH NVYWHCKLLL QLAQIHASDR EYSLASDLLA VGAENADEAG ATYLKVLFLL
     SRAMILMIER KTNDVLALLN SAGQIIDNNI PNPHQKEYLK VFFLVLQVCY YLALGQVKTV
     KPSLKQLQMS IQTIMAPNWP SDETIFGANQ LEMFVWLPKE QLYVLVYLVT VSHSMMAGYM
     DKAQKYTEKA LTQIEKLKQQ EDKPILSVFK VILLEHIVMC RMVMGNRELA IREIAAARDV
     CLAAPQRSLL RRHSAQLHCL IGLYSMSTSF FEHAERQFLV CVSETNERDL KLFANLNLAI
     IYLRTKRDTD LKQILDAVSS ENTNTYSSQA LMGGFYYVQG LHAFHKNSFH EAKRFLRETL
     KMANAEDLNR LTSCSLVLLS HVFLSIGNSK ESMNMVTPAM QLASKIPDIH VQLWGSAILK
     DLHRMSKDAQ HEKDAYANHL KYSENLIADQ RKSVQSSHHE LVNWFHGDPP VTSGPPTTTA
     VAMILPDSSA AVGPVPVIAS TSTGMQQAIQ PVGQYGQFY