SCC4_DROGR
ID SCC4_DROGR Reviewed; 623 AA.
AC B4JHK2;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=MAU2 chromatid cohesion factor homolog;
DE AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN ORFNames=GH18976;
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for association of the cohesin complex with
CC chromatin during interphase. Plays a role in sister chromatid cohesion
CC and normal progression through prometaphase (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with Nipped-B to form the cohesin loading complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Note=Binds to
CC chromatin from the end of mitosis until prophase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR EMBL; CH916369; EDV92829.1; -; Genomic_DNA.
DR RefSeq; XP_001989767.1; XM_001989731.1.
DR AlphaFoldDB; B4JHK2; -.
DR STRING; 7222.FBpp0152882; -.
DR EnsemblMetazoa; FBtr0154390; FBpp0152882; FBgn0126443.
DR GeneID; 6564191; -.
DR KEGG; dgr:6564191; -.
DR eggNOG; KOG2300; Eukaryota.
DR HOGENOM; CLU_030238_0_0_1; -.
DR InParanoid; B4JHK2; -.
DR OMA; SSQDAWY; -.
DR OrthoDB; 240898at2759; -.
DR PhylomeDB; B4JHK2; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR019440; MAU2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR21394; PTHR21394; 1.
DR Pfam; PF10345; Cohesin_load; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..623
FT /note="MAU2 chromatid cohesion factor homolog"
FT /id="PRO_0000382731"
FT REPEAT 96..129
FT /note="TPR 1"
FT REPEAT 451..484
FT /note="TPR 2"
FT REPEAT 491..524
FT /note="TPR 3"
SQ SEQUENCE 623 AA; 70298 MW; 249E8E915258DF78 CRC64;
MSVANTTAAS QDACYISLLG LAEYFRTSQP PNIKKCIQCL QALFTFQPPS KVEARTHLQM
GQVLMAYTCN IDLARRHLEQ AWSISEPLMN FDDVKFDTAS LLAQLHLKTE QSPHAKAMLR
RAVELSQNNV YWHCKLLLQL SQIHANDREY SLASDLLAVG AESAEEAGAT YLKVLFLLSR
AMILMIERKT NDVLALLNSA GQIIDNNIPN PHQKEYLKVF FLVLQVCYYL ALGQVKTVKP
SLKQLQMSIQ TIMAPNWPSD ESIFGGNQLE MFVWLPKEQL YVLVYLVTVS HSMMAGYMDK
AQKYTEKALT QIEKLKLQED KSILSVFKVI LLEHIVMCRM VMGNRELAIR EIAAARDVCL
AVPHRSLLKR HSAQLHCLIG LYSMSTSFFE HAERQFLVCV NETGERDLKL FANLNLAIIY
LRTKRDADLK QILDAVSTEN THTYSSQALM GGFYYVQGLH AFHKNSFHEA KRFLRETLKM
ANAEDLNRLT SCSLVLLSHV FLSIGNSKES MNMVTPAMQL ASKIPDIHVQ LWGSAILKDL
HRMSKDVQHE KEAYANHVKY SENLIADQRK CVQSAHHELV NWFQGDPPLT SGASLTHLPV
AAAAPEASTS SLQASTAQFG QFY
