SCC4_DROME
ID SCC4_DROME Reviewed; 632 AA.
AC Q9VFC0;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=MAU2 chromatid cohesion factor homolog {ECO:0000250|UniProtKB:Q9Y6X3};
DE AltName: Full=Cohesin loading complex subunit SCC4 homolog {ECO:0000250|UniProtKB:Q9Y6X3};
DE AltName: Full=Mau2 sister chromatid cohesion factor {ECO:0000312|FlyBase:FBgn0038300};
GN Name=Mau2 {ECO:0000312|FlyBase:FBgn0038300};
GN ORFNames=CG4203 {ECO:0000312|FlyBase:FBgn0038300};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Required for association of the cohesin complex with
CC chromatin during interphase. Plays a role in sister chromatid cohesion
CC and normal progression through prometaphase (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with Nipped-B to form the cohesin loading complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Note=Binds to
CC chromatin from the end of mitosis until prophase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF55140.1; -; Genomic_DNA.
DR EMBL; AY069560; AAL39705.1; -; mRNA.
DR RefSeq; NP_650428.1; NM_142171.4.
DR AlphaFoldDB; Q9VFC0; -.
DR BioGRID; 66894; 2.
DR DIP; DIP-29197N; -.
DR IntAct; Q9VFC0; 2.
DR STRING; 7227.FBpp0082507; -.
DR PaxDb; Q9VFC0; -.
DR PRIDE; Q9VFC0; -.
DR DNASU; 41830; -.
DR EnsemblMetazoa; FBtr0083048; FBpp0082507; FBgn0038300.
DR GeneID; 41830; -.
DR KEGG; dme:Dmel_CG4203; -.
DR UCSC; CG4203-RA; d. melanogaster.
DR CTD; 23383; -.
DR FlyBase; FBgn0038300; Mau2.
DR VEuPathDB; VectorBase:FBgn0038300; -.
DR eggNOG; KOG2300; Eukaryota.
DR GeneTree; ENSGT00390000012198; -.
DR HOGENOM; CLU_030238_0_0_1; -.
DR InParanoid; Q9VFC0; -.
DR OMA; SSQDAWY; -.
DR OrthoDB; 240898at2759; -.
DR PhylomeDB; Q9VFC0; -.
DR Reactome; R-DME-2470946; Cohesin Loading onto Chromatin.
DR SignaLink; Q9VFC0; -.
DR BioGRID-ORCS; 41830; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41830; -.
DR PRO; PR:Q9VFC0; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038300; Expressed in egg cell and 21 other tissues.
DR Genevisible; Q9VFC0; DM.
DR GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; ISS:FlyBase.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR019440; MAU2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR21394; PTHR21394; 1.
DR Pfam; PF10345; Cohesin_load; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..632
FT /note="MAU2 chromatid cohesion factor homolog"
FT /id="PRO_0000382732"
FT REPEAT 453..486
FT /note="TPR 1"
FT REPEAT 493..526
FT /note="TPR 2"
SQ SEQUENCE 632 AA; 71217 MW; CB1B9D3D3F4A54A5 CRC64;
MSASTSTSTA ASQDACYISL LGLAEYFRTS QPPNIKKCIQ CLQALFTFMP PSKVEARTHL
QMGQILMAYT KNIDLARQHL EKAWSISEPL PNFDVKFDTA SLLAQLHLQT DRNSHQAKAM
LRRAVELSQN NVYWHCKLLL QLAQIHASDR EYSLASELLA VGAESADEAS ATYLKVLFLL
SRAMILMIER KTNDVLALLN SAGQIIDNNI PNPHQKEYLK VFFLVLQVCY YLALGQVKTV
KPSLKQLQMS IQTIMAPNWP SDEAIFGANQ LEMFVWLPKE QLYVLVYLVT VSHSMMAGYM
DKAQKYTEKA LTQIEKLKQQ EDKPILSVFK VILLEHIVMC RMVMGNRELA IREIAAARDV
CMAAPQRSLL RRHSAQLHCL IGLYSMSTNL FEHAERQFVV CVSETSERDL KLFANLNLAI
IYLRTKRDTD LKQILDAVST ENTHTYSSQA LMGGFYYVQG LHAFHKNSFH EAKRFLRETL
KMANAEDLNR LTSCSLVLLS HVFLSIGNSK ESMNMVTPAM QLASKIPDIH VQLWGSAILK
DLHRMSKDVQ HEKDAYANHV KYSENLIADQ RKCVQSAHHE LVNWFQGDPP VTSGPPAAPV
LLMPESSVTA SVPVIASTST AMQPAGQYGQ FY
