SCC4_DROMO
ID SCC4_DROMO Reviewed; 625 AA.
AC B4K4X6;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=MAU2 chromatid cohesion factor homolog;
DE AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN ORFNames=GI22403;
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for association of the cohesin complex with
CC chromatin during interphase. Plays a role in sister chromatid cohesion
CC and normal progression through prometaphase (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with Nipped-B to form the cohesin loading complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Note=Binds to
CC chromatin from the end of mitosis until prophase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR EMBL; CH933806; EDW16129.1; -; Genomic_DNA.
DR RefSeq; XP_002000668.1; XM_002000632.2.
DR AlphaFoldDB; B4K4X6; -.
DR STRING; 7230.FBpp0171620; -.
DR EnsemblMetazoa; FBtr0173128; FBpp0171620; FBgn0145131.
DR GeneID; 6574634; -.
DR KEGG; dmo:Dmoj_GI22403; -.
DR eggNOG; KOG2300; Eukaryota.
DR HOGENOM; CLU_030238_0_0_1; -.
DR InParanoid; B4K4X6; -.
DR OMA; SSQDAWY; -.
DR OrthoDB; 240898at2759; -.
DR PhylomeDB; B4K4X6; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR019440; MAU2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR21394; PTHR21394; 1.
DR Pfam; PF10345; Cohesin_load; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..625
FT /note="MAU2 chromatid cohesion factor homolog"
FT /id="PRO_0000382733"
FT REPEAT 96..129
FT /note="TPR 1"
FT REPEAT 451..484
FT /note="TPR 2"
FT REPEAT 491..524
FT /note="TPR 3"
FT REGION 600..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 625 AA; 70787 MW; BF3E88F72D75A344 CRC64;
MSVVSTTPAS QDACYISLLG LAEYFRTSQP PNIKKCIQCL QALFTFQPPS KVEARTHLQM
GQVLMAYTCN IDLARRHLEQ AWSIAEPLMN FDDVKFDTAS LLAQLHLKTE QSSHAKAMLR
RAVELSQNNV YWHCKLLLQL SQIHASDREY SLASDLLAVG AESAEEAGAT YLKVLFLLSR
AMILMIERKT NDVLALLNSA GQIIDNNIPN PHQKEYLKVF FLVLQVCYYL ALGQVKTVKP
SLKQLQMSIQ TIMAPNWPSD ETIFGGNQLE MFVWLPKEQL YVLVYLVTVS HSMMAGYMDK
AQKYTEKALT QIEKLKQQED KSILSVFKVI LLEHIVMCRM VMGNRELAIR EIAAARDVCL
AVPHRNLLKR HSAQLHCLIG LYSMSTSFFE HAERQFLVCV NETTERDLKL FANLNLAIIY
LRTKREADLK QILDAVSTEN THTYSSQALM GGFYYVQGLH AFHKNSFHEA KRFLRETLKM
ANAEDLNRLT SCSLVLLSHV FLSIGNSKES MNMVTPAMQL ASKIPDIHVQ LWGSAILKDL
HRMSKDAQHE KEAYANHVKY SENLIADQRK CVQSAHHELI NWFQGNPPVT SNSSLNPAVT
VPTTETSTSA LQQPQQPAAQ FGQFY
