ID   SCC4_DROPS              Reviewed;         620 AA.
AC   Q296H8;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=MAU2 chromatid cohesion factor homolog;
DE   AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN   ORFNames=GA18027;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Required for association of the cohesin complex with
CC       chromatin during interphase. Plays a role in sister chromatid cohesion
CC       and normal progression through prometaphase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with Nipped-B to form the cohesin loading complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Note=Binds to
CC       chromatin from the end of mitosis until prophase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR   EMBL; CM000070; EAL28479.2; -; Genomic_DNA.
DR   RefSeq; XP_001359334.2; XM_001359297.4.
DR   AlphaFoldDB; Q296H8; -.
DR   STRING; 7237.FBpp0284397; -.
DR   EnsemblMetazoa; FBtr0285959; FBpp0284397; FBgn0078035.
DR   GeneID; 4802411; -.
DR   KEGG; dpo:Dpse_GA18027; -.
DR   eggNOG; KOG2300; Eukaryota.
DR   HOGENOM; CLU_030238_0_0_1; -.
DR   InParanoid; Q296H8; -.
DR   OMA; SSQDAWY; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0078035; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR019440; MAU2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR21394; PTHR21394; 1.
DR   Pfam; PF10345; Cohesin_load; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..620
FT                   /note="MAU2 chromatid cohesion factor homolog"
FT                   /id="PRO_0000382735"
FT   REPEAT          452..485
FT                   /note="TPR 1"
FT   REPEAT          492..525
FT                   /note="TPR 2"
SQ   SEQUENCE   620 AA;  70145 MW;  B2209CDBB9D0F99B CRC64;
     MSTTNTAAAS QDACYISLLG LAEYFRTSQP PNVKKCIQCL QALFTFTPPS KVEARTHLQM
     GQILMAYTKN IDMARQHLEK AWNIAEPLMN FDDVKFDTAS VLAQLHLQTD QSSHTAKAML
     RRAVELSQHN VYWHCKLLLQ LSQIHASDRE YSLASELLAV GAESAEEAGA TYLKVLFLLS
     RAMILMIERK TNDVLALLNT AGQIIDNNIP NPHQKEYLKV FFLVLQVCYY LALGQVKTVK
     PSLKQLQMSI QTIMAPNWPT DEAIFGANQL EMFVWLPKEQ LYVLVYLVTV SHSMMAGYMD
     KAQKYTEKAL TQIEKLKMQE DKPILSVFKV ILLEHIVMCR MVMGNRELAI REIAAARDVC
     LAVPHRSLLK RHSAQLHCLI GLYSMSTSFF EHAERQFLVC VNETTERDLK LFANLNLAII
     YLRTKRDADL KQILDAVSTE NTHTYSSQAL MGGFYYVQGL HAFHKNSFHE AKRFLRETLK
     MANAEDLNRL TSCSLVLLSH VFLSIGNSKE SMNMVTPAMQ LASKIPDIHV QLWGSAILKD
     LHRMSKDAQH EKDAYANHVK YSENLIADQR KCVQSAHHEL VNWFQGDPPV TSGAAALILS
     EIPTTSALQP TTGQQFGQFY