ID   SCC4_DROSE              Reviewed;         632 AA.
AC   B4HE12;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=MAU2 chromatid cohesion factor homolog;
DE   AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN   ORFNames=GM24202;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for association of the cohesin complex with
CC       chromatin during interphase. Plays a role in sister chromatid cohesion
CC       and normal progression through prometaphase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with Nipped-B to form the cohesin loading complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Note=Binds to
CC       chromatin from the end of mitosis until prophase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR   EMBL; CH480815; EDW42104.1; -; Genomic_DNA.
DR   RefSeq; XP_002031118.1; XM_002031082.1.
DR   AlphaFoldDB; B4HE12; -.
DR   STRING; 7238.B4HE12; -.
DR   EnsemblMetazoa; FBtr0207187; FBpp0205679; FBgn0179066.
DR   GeneID; 6606313; -.
DR   KEGG; dse:6606313; -.
DR   HOGENOM; CLU_030238_0_0_1; -.
DR   OMA; SSQDAWY; -.
DR   PhylomeDB; B4HE12; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR019440; MAU2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR21394; PTHR21394; 1.
DR   Pfam; PF10345; Cohesin_load; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..632
FT                   /note="MAU2 chromatid cohesion factor homolog"
FT                   /id="PRO_0000382736"
FT   REPEAT          453..486
FT                   /note="TPR 1"
FT   REPEAT          493..526
FT                   /note="TPR 2"
SQ   SEQUENCE   632 AA;  71231 MW;  24E298A7D6FA2EB2 CRC64;
     MSASTSTSTA ASQDACYISL LGLAEYFRTS QPPNIKKCIQ CLQALFTFMP PSKVEARTHL
     QMGQILMAYT KNIDLARQHL EKAWSISEPL PNFDVKFDTA SLLAQLHLQT DRNSHQAKAM
     LRRAVELSQN NVYWHCKLLL QLSQIHASDR EYSLASELLA VGAESADEAS ATYLKVLFLL
     SRAMILMIER KTNDVLALLN SAGQIIDNNI PNPHQKEYLK VFFLVLQVCY YLALGQVKTV
     KPSLKQLQMS IQTIMAPNWP SDEAIFGANQ LEMFVWLPKE QLYVLVYLVT VSHSMMAGYM
     DKAQKYTEKA LTQIEKLKQQ EDKPILSVFK VILLEHIVMC RMVMGNRELA IREIAAARDV
     CMAAPQRSLL RRHSAQLHCL IGLYSMSTNL FEHAERQFVV CVSETSERDL KLFANLNLAI
     IYLRTKRDTD LKQILDAVST ENTHTYSSQA LMGGFYYVQG LHAFHKNSFH EAKRFLRETL
     KMANAEDLNR LTSCSLVLLS HVFLSIGNSK ESMNMVTPAM QLASKIPDIH VQLWGSAILK
     DLHRMSKDVQ HEKDAYANHV KYSENLIADQ RKCVQSAHHE LVNWFQGDPP VTSGPPAVPV
     LLMPESSVTA SVPVIASTSA AMQPAGQYGQ FY