ID   SCC4_DROVI              Reviewed;         621 AA.
AC   B4M4L4;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=MAU2 chromatid cohesion factor homolog;
DE   AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN   ORFNames=GJ10962;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for association of the cohesin complex with
CC       chromatin during interphase. Plays a role in sister chromatid cohesion
CC       and normal progression through prometaphase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with Nipped-B to form the cohesin loading complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Note=Binds to
CC       chromatin from the end of mitosis until prophase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR   EMBL; CH940652; EDW59575.1; -; Genomic_DNA.
DR   RefSeq; XP_002056463.1; XM_002056427.2.
DR   AlphaFoldDB; B4M4L4; -.
DR   STRING; 7244.FBpp0225379; -.
DR   EnsemblMetazoa; FBtr0226887; FBpp0225379; FBgn0198230.
DR   GeneID; 6632657; -.
DR   KEGG; dvi:6632657; -.
DR   eggNOG; KOG2300; Eukaryota.
DR   HOGENOM; CLU_030238_0_0_1; -.
DR   InParanoid; B4M4L4; -.
DR   OMA; SSQDAWY; -.
DR   OrthoDB; 240898at2759; -.
DR   PhylomeDB; B4M4L4; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR019440; MAU2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR21394; PTHR21394; 1.
DR   Pfam; PF10345; Cohesin_load; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..621
FT                   /note="MAU2 chromatid cohesion factor homolog"
FT                   /id="PRO_0000382738"
FT   REPEAT          96..129
FT                   /note="TPR 1"
FT   REPEAT          451..484
FT                   /note="TPR 2"
FT   REPEAT          491..524
FT                   /note="TPR 3"
SQ   SEQUENCE   621 AA;  70184 MW;  F8B94D7891913168 CRC64;
     MSGVNTTAAS QDACYISLLG LAEYFRTSQP PNIKKCIQCL QALFTFQPPS KVEARTHLQM
     GQVLMAYTRN IDLARQHLEQ AWSISEPLMN FDDVKFDTAS LLAQLHLQTE QSSHAKAMLR
     RAVELSQNNV YWHCKLLLQL SQIHANDREY SLASDLLAVG AESAEEAGAT YLKVLFLLSR
     AMILMIERKT NDVLALLNSA GQIIDNNIPN PHQKEYLKVF FLVLQVCYYL ALGQVKTVKP
     SLKQLQMSIQ TIMAPNWPSD EVIFGANQLE MFVWLPKEQL YVLVYLVTVS HSMMAGYMDK
     AQKYTEKALT QIEKLKLQED KSILSVFKVI LLEHIVMCRM VMGNRELAIR EIAAARDVCI
     AAPHRNLLKR HSAQLHCLIG LYSMSTSFFE HAERQFLVCV NETGERDLKL FANLNLAIIY
     LRTKREADLK QILDAVSTEN THTYSSQALM GGFYYVQGLH AFHKNSFHEA KRFLRETLKM
     ANAEDLNRLT SCSLVLLSHV FLSIGNSKES MNMVTPAMQL ASKIPDIHVQ LWGSAILKDL
     HRMSKDAQHE KEAYANHVKY SENLIADQRK CVQSAHHELV NWFQGDPPVT SGASLNLPVA
     VATTEASTSA IQQPAQFGQF Y