ID   SCC4_DROWI              Reviewed;         663 AA.
AC   B4NKT1;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=MAU2 chromatid cohesion factor homolog;
DE   AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN   ORFNames=GK13302;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for association of the cohesin complex with
CC       chromatin during interphase. Plays a role in sister chromatid cohesion
CC       and normal progression through prometaphase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with Nipped-B to form the cohesin loading complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Note=Binds to
CC       chromatin from the end of mitosis until prophase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDW84142.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CH964272; EDW84142.1; ALT_FRAME; Genomic_DNA.
DR   RefSeq; XP_002073156.2; XM_002073120.2.
DR   AlphaFoldDB; B4NKT1; -.
DR   STRING; 7260.FBpp0242445; -.
DR   EnsemblMetazoa; FBtr0243953; FBpp0242445; FBgn0215311.
DR   GeneID; 6650393; -.
DR   KEGG; dwi:6650393; -.
DR   eggNOG; KOG2300; Eukaryota.
DR   InParanoid; B4NKT1; -.
DR   OrthoDB; 240898at2759; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR019440; MAU2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR21394; PTHR21394; 1.
DR   Pfam; PF10345; Cohesin_load; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..663
FT                   /note="MAU2 chromatid cohesion factor homolog"
FT                   /id="PRO_0000382739"
FT   REPEAT          455..488
FT                   /note="TPR 1"
FT   REPEAT          495..528
FT                   /note="TPR 2"
SQ   SEQUENCE   663 AA;  73979 MW;  F2E7B8568FE66E84 CRC64;
     MSGPSSANPA ASQDACYISL LGLAEYFRTS QPPNIKKCIQ CLQALFTFTP PSKVEARTHL
     QMGQILMAYT RNIDMARQHL EKAWNISESL MNFDDVKFDT ASLLAQLHLQ TEPSSNAAKA
     MLRRAVELSQ NNVYWHCKLL LQLSQIHASD REYSSASELL AVGADSAEEA GATYLKVLFL
     LSRAMILMIE RKTNDVLALL NSAGQIIDNN IPNPHQKEYL KVFFLVLQVC YYLALGQVKT
     VKPSLKQLQM SIQTIMAPNW PSDDTIFGSN QLEMFVWLPK EQLYVLVYLV TVSHSMMAGY
     MDKAQKYTEK ALTQIEKLKL QEDKPILSVF KVILLEHIVM CRMVMGNREL AIREIAAARD
     VCLAAPQRRS LLKRHSAQLH CLIGLYAMST SFFDHAERQF LVCVSETTER DLKLFANLNL
     AIIYLRTKRE TDLKQILDAV STENTHTYSS QALMGGFYYV QGLHAFHKNS FHEAKRFLRE
     TLKMANAEDL NRLTSCSLVL LSHVFLSIGN SKESMNMVTP AMQLASKIPD IHVQLWGSAI
     LKDLHRMSKD AQHEKEAYAN HVKYSENLIA DQRKCVQSSH HELVNWFHGD PPITTGAPLT
     LPVIPEAINN PVTPLTPSSA AVAATAGAAA STTPMTQTNV AVASTSALQP PVGAVAGQFG
     QFY