ID   SCC4_NEMVE              Reviewed;         611 AA.
AC   A7SUU7;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=MAU2 chromatid cohesion factor homolog;
DE   AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN   ORFNames=v1g174619;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Required for association of the cohesin complex with
CC       chromatin during interphase. Plays a role in sister chromatid cohesion
CC       and normal progression through prometaphase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the cohesin loading complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Note=Binds to
CC       chromatin from the end of mitosis until prophase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR   EMBL; DS469820; EDO32521.1; -; Genomic_DNA.
DR   RefSeq; XP_001624621.1; XM_001624571.1.
DR   AlphaFoldDB; A7SUU7; -.
DR   STRING; 45351.EDO32521; -.
DR   EnsemblMetazoa; EDO32521; EDO32521; NEMVEDRAFT_v1g174619.
DR   eggNOG; KOG2300; Eukaryota.
DR   HOGENOM; CLU_030238_0_0_1; -.
DR   InParanoid; A7SUU7; -.
DR   OMA; SSQDAWY; -.
DR   OrthoDB; 240898at2759; -.
DR   PhylomeDB; A7SUU7; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR019440; MAU2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR21394; PTHR21394; 1.
DR   Pfam; PF10345; Cohesin_load; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..611
FT                   /note="MAU2 chromatid cohesion factor homolog"
FT                   /id="PRO_0000382741"
FT   REPEAT          11..46
FT                   /note="TPR 1"
FT   REPEAT          91..124
FT                   /note="TPR 2"
FT   REPEAT          131..164
FT                   /note="TPR 3"
FT   REPEAT          371..404
FT                   /note="TPR 4"
FT   REPEAT          490..523
FT                   /note="TPR 5"
FT   REGION          581..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        583..611
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   611 AA;  69033 MW;  349E9C777DDF7F30 CRC64;
     MAVILSVDPC YAGLVGLAEG FRTSNPPRIR ECIQCLQAIL QFNPPPATQA KTHLQIGRIL
     QQYTKNDDLA RRTLEKAVSA ELGHGYEEIS FEASSILSLV YKDQGQYPLA KQVLRQALEI
     TSGENLYFWQ FRLFFQLAEV HACDNEFTAS VEVLEMGERI AEQCGSQYMR YNIRHSHNCI
     IIVLLIMKDV NRVSNILMST GSFLERWQGQ SYQRESLVVF HLLLRVWQLL SVGQAKTVRP
     YLKQLQQSIQ NLTTMTFEGM QPGPNVYEAE KFEWLPREHL CVLVYLVTVM HSMYAGYMDK
     VLKYSAKALN QVERLKVTSP SALVSVFQLM LLEHTIMCRV VQGQPAHAIK EISQVYQTLK
     HENCLVRAHK PILHTLLGLY AMSMNLMEQA TTHFNIAFKT ADNPVLANFV GLNLSIIYIR
     AGESKQIELS SVMSSIHPSN MATNSHSLQA GYYYVCALRA FFQTRIQDAK KYLRESLKIA
     NAEDLNRLTA CSLVLLGHTF LASGNPQEAL NMVLPATQLS GKIPDNYIQL WAAGLLRDLY
     GMLGQPVQAS ESFHKHHSIT KQLIENHMQA RKLPEHGLTE WTGAVSPTKS STIPPQQSFQ
     TWSQPGPSRL S