ID   SCC4_SCHPO              Reviewed;         559 AA.
AC   O94459;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=MAU2 chromatid cohesion factor homolog;
DE   AltName: Full=Sister chromatid cohesion protein ssl3;
GN   Name=ssl3; ORFNames=SPAC1687.18c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION, AND INTERACTION WITH MIS4 AND RAD21.
RX   PubMed=16682348; DOI=10.1016/j.cub.2006.03.037;
RA   Bernard P., Drogat J., Maure J.-F., Dheur S., Vaur S., Genier S.,
RA   Javerzat J.-P.;
RT   "A screen for cohesion mutants uncovers ssl3, the fission yeast counterpart
RT   of the cohesin loading factor scc4.";
RL   Curr. Biol. 16:875-881(2006).
CC   -!- FUNCTION: Involved in sister chromatid cohesion. Forms a complex with
CC       mis4, which is required for the association of the cohesin complex with
CC       chromosomes. {ECO:0000269|PubMed:16682348}.
CC   -!- SUBUNIT: Interacts with mis4 and rad21. {ECO:0000269|PubMed:16682348}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Associates with chromatin.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAA22612.1; -; Genomic_DNA.
DR   PIR; T37761; T37761.
DR   RefSeq; NP_593137.1; NM_001018533.2.
DR   AlphaFoldDB; O94459; -.
DR   BioGRID; 278768; 7.
DR   STRING; 4896.SPAC1687.18c.1; -.
DR   MaxQB; O94459; -.
DR   PaxDb; O94459; -.
DR   EnsemblFungi; SPAC1687.18c.1; SPAC1687.18c.1:pep; SPAC1687.18c.
DR   GeneID; 2542301; -.
DR   KEGG; spo:SPAC1687.18c; -.
DR   PomBase; SPAC1687.18c; ssl3.
DR   VEuPathDB; FungiDB:SPAC1687.18c; -.
DR   eggNOG; ENOG502RK5N; Eukaryota.
DR   HOGENOM; CLU_491032_0_0_1; -.
DR   InParanoid; O94459; -.
DR   OMA; EIPTRTH; -.
DR   PhylomeDB; O94459; -.
DR   Reactome; R-SPO-2470946; Cohesin Loading onto Chromatin.
DR   PRO; PR:O94459; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0090694; C:Scc2-Scc4 cohesin loading complex; EXP:PomBase.
DR   GO; GO:0032116; C:SMC loading complex; IDA:PomBase.
DR   GO; GO:0003690; F:double-stranded DNA binding; IDA:PomBase.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0140588; P:chromatin looping; IDA:PomBase.
DR   GO; GO:0061780; P:mitotic cohesin loading; IDA:PomBase.
DR   GO; GO:0062022; P:mitotic cohesin ssDNA (lagging strand) loading; IDA:PomBase.
DR   InterPro; IPR019440; MAU2.
DR   PANTHER; PTHR21394; PTHR21394; 1.
DR   Pfam; PF10345; Cohesin_load; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..559
FT                   /note="MAU2 chromatid cohesion factor homolog"
FT                   /id="PRO_0000116739"
SQ   SEQUENCE   559 AA;  64772 MW;  E0003AF06A42884B CRC64;
     MTGLNETDAR ILVTSRHLFL WPLAETYFKN AEKVLQDCGV CDSFGRLLST GLQCLYSVLM
     DTKMEPRVEL LTRKRICEVL LSHTVEYADV EAILNRALII AEQHNLTEYK FSLQLLLSRV
     FCRTSPKAAK VLLTRCVREA EEYAKVAEIY HSNNQSNPHR WVYEFLLATL EFQNVSQVAN
     SIHNYANHHK HQHLQLLAMI LNQSLPMDEI STDSDQISIL CLVTQIAQCL RKGEILLARE
     ILPKIHSKLE SETFVWPSSY IDFFIDDTSK ISIKWMSINQ LYLLIYLISG FCYISDSTSG
     RASRFLQEGL RITGDFKHQE RCVLEYLESQ KWINNITKDM KYYLIATYLS RSRLSKAERI
     LQSTEDDQTG FLGILKGMYL QKRGDLKKAE VHYRETAKNF SFRTDTFIIS TLNLINILED
     SAAASRCLES IEPLCNKHEK KIFKLWLLVL KVIREGPQVH QSNVLPRVIQ QSSEYANTQL
     QYISLTELSE RFGKLEHAEK MAISALELAK KSKDELWCLI SGRILEDFYR SVQKYDKMRQ
     QALENSAYSK LIEDIYSFV