ID   SCC4_XENLA              Reviewed;         607 AA.
AC   B4ZIX8;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=MAU2 chromatid cohesion factor homolog;
DE            Short=MAU-2;
DE   AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN   Name=mau2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=18628396; DOI=10.1101/gad.1683308;
RA   Takahashi T.S., Basu A., Bermudez V., Hurwitz J., Walter J.C.;
RT   "Cdc7-Drf1 kinase links chromosome cohesion to the initiation of DNA
RT   replication in Xenopus egg extracts.";
RL   Genes Dev. 22:1894-1905(2008).
RN   [2]
RP   SUBUNIT.
RX   PubMed=16682347; DOI=10.1016/j.cub.2006.03.049;
RA   Watrin E., Schleiffer A., Tanaka K., Eisenhaber F., Nasmyth K.,
RA   Peters J.M.;
RT   "Human Scc4 is required for cohesin binding to chromatin, sister-chromatid
RT   cohesion, and mitotic progression.";
RL   Curr. Biol. 16:863-874(2006).
CC   -!- FUNCTION: Plays an important role in the loading of the cohesin complex
CC       on to DNA. Plays a role in sister chromatid cohesion and normal
CC       progression through prometaphase. {ECO:0000250|UniProtKB:Q9Y6X3}.
CC   -!- SUBUNIT: Interacts with one or more paralogs of nipbl to form the
CC       cohesin loading complex. {ECO:0000269|PubMed:16682347}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q9Y6X3}. Note=Binds to chromatin from the end of
CC       mitosis until prophase. {ECO:0000250|UniProtKB:Q9Y6X3}.
CC   -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR   EMBL; EU747648; ACF40224.1; -; mRNA.
DR   RefSeq; NP_001124425.1; NM_001130953.1.
DR   AlphaFoldDB; B4ZIX8; -.
DR   MaxQB; B4ZIX8; -.
DR   GeneID; 100174813; -.
DR   KEGG; xla:100174813; -.
DR   CTD; 100174813; -.
DR   Xenbase; XB-GENE-5991498; mau2.S.
DR   OrthoDB; 240898at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 100174813; Expressed in blastula and 19 other tissues.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0090694; C:Scc2-Scc4 cohesin loading complex; ISS:UniProtKB.
DR   GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071921; P:cohesin loading; ISS:UniProtKB.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR019440; MAU2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR21394; PTHR21394; 1.
DR   Pfam; PF10345; Cohesin_load; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..607
FT                   /note="MAU2 chromatid cohesion factor homolog"
FT                   /id="PRO_0000382724"
FT   REPEAT          102..135
FT                   /note="TPR 1"
FT   REPEAT          374..407
FT                   /note="TPR 2"
FT   REPEAT          453..486
FT                   /note="TPR 3"
FT   REPEAT          493..526
FT                   /note="TPR 4"
SQ   SEQUENCE   607 AA;  68866 MW;  0FCE1022ED4CAFFB CRC64;
     MSVMAATAVV SPQAEASESW YLALLGFAEH FRTSSPPKIR LCVHCLQAVF QFKPPQRIEA
     RTHLQLGSVL YHHTKNSELA RQHLEKAWFI SQQIPQFEDV KFEAASLLSE LYCQENSVDA
     AKPLLRKAIQ ISQQTPYWHC RLLFQLAQLH TLEKDLVSAC DLLGVGAEYA RVVGSEYTRA
     LFLLSKGMLL LMERKLQEVH PLLTLCGQIV ENWQGNPIQK ESLRVFFLVL QVTHYLDAGQ
     VKSVKPCLKQ LQQCIQTIST LHDDEILPSN PADLFHWLPK EHMCVLVYLV TVMHSMQAGY
     LEKAQKYTDK ALMQLEKLKM LDSSPILSSF QVILLEHIIM CRLVTGHKAT ALQEISQLCQ
     LCQQSPRLFS NHAAQLHTLL GLYCISVNCM DNAEAQFTTA LRLTTHQELW TFIVTNLASV
     YIREGNRHQE LYALLERINP DHNFPVSSHC LRAAAFYIRG LFSFFQGRYN EAKRFLRETL
     KMSNAEDLNR LTACSLVLLG HIFYVLGNHR ESNNMVVPAM QLASKIPDMS VQLWSSALLR
     DLNKACGNNI DAHEAAQMHQ NFSQQLLQDH IEACSLPEHN LITWTDGSPP VQFQAQNGPT
     TSLASLL