ID   SCC4_XENTR              Reviewed;         604 AA.
AC   B1H1Z8;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=MAU2 chromatid cohesion factor homolog;
DE            Short=MAU-2;
DE   AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN   Name=mau2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16802858; DOI=10.1371/journal.pbio.0040242;
RA   Seitan V.C., Banks P., Laval S., Majid N.A., Dorsett D., Rana A., Smith J.,
RA   Bateman A., Krpic S., Hostert A., Rollins R.A., Erdjument-Bromage H.,
RA   Tempst P., Benard C.Y., Hekimi S., Newbury S.F., Strachan T.;
RT   "Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon
RT   migration guidance.";
RL   PLoS Biol. 4:E242-E242(2006).
CC   -!- FUNCTION: Plays an important role in the loading of the cohesin complex
CC       on to DNA. Plays a role in sister chromatid cohesion and normal
CC       progression through prometaphase. {ECO:0000250|UniProtKB:Q9Y6X3}.
CC   -!- SUBUNIT: Interacts with nipbl to form the cohesin loading complex.
CC       {ECO:0000250|UniProtKB:B4ZIX8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q9Y6X3}. Note=Binds to chromatin from the end of
CC       mitosis until prophase. {ECO:0000250|UniProtKB:Q9Y6X3}.
CC   -!- DISRUPTION PHENOTYPE: Early embryos exhibit numerous developmental
CC       defects including shortening of the A-P axis, ventralization, and
CC       defects in neural, somite, head, eye, and tail development.
CC       {ECO:0000269|PubMed:16802858}.
CC   -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC160796; AAI60796.1; -; mRNA.
DR   AlphaFoldDB; B1H1Z8; -.
DR   STRING; 8364.ENSXETP00000058524; -.
DR   PaxDb; B1H1Z8; -.
DR   eggNOG; KOG2300; Eukaryota.
DR   HOGENOM; CLU_030238_0_0_1; -.
DR   InParanoid; B1H1Z8; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0090694; C:Scc2-Scc4 cohesin loading complex; ISS:UniProtKB.
DR   GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071921; P:cohesin loading; ISS:UniProtKB.
DR   GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR019440; MAU2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR21394; PTHR21394; 1.
DR   Pfam; PF10345; Cohesin_load; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..604
FT                   /note="MAU2 chromatid cohesion factor homolog"
FT                   /id="PRO_0000382725"
FT   REPEAT          99..132
FT                   /note="TPR 1"
FT   REPEAT          371..404
FT                   /note="TPR 2"
FT   REPEAT          450..483
FT                   /note="TPR 3"
FT   REPEAT          490..523
FT                   /note="TPR 4"
SQ   SEQUENCE   604 AA;  68490 MW;  DA23AE0F3E129335 CRC64;
     MAATAVVAPQ AEASESWYLA LLGFAEHFRT SSPPKIRLCV HCLQAVFQFK PSQRIEARTH
     LQLGSVLYHH TKNSELARQH LEKAWLISQQ IPQFEDVKFE AASLLSELYC QENSVDAAKP
     LLRKAIQISQ QTPYWHCRLL FQLAQLHTLE KDLVSACDLL GVGAEYARVV GSEYTRALFL
     LSKGMLLLME RKLQEVHPLL TLCGQIVENW QGNPIQKESL RVFFLVLQVT HYLDAGQVKS
     VKPCLKQLQQ CIQTISTLHD DEILPSNPAD LFHWLPKEHM CVLVYLVTVM HSMQAGYLEK
     AQKYTDKALM QLEKLKMLDS SPILSSFQVI LLEHIIMCRL VTGHKATALQ EISQVCQLCQ
     QSPRLFSNHA AQLHTLLGLY CISVNCMDNA EAQFTTALRL TTHQELWTFI VTNLASVYIR
     EGNRHQELYS LLERINPDHN FPVSSHCLRA AAFYIRGLFS FFQGRYNEAK RFLRETLKMS
     NAEDLNRLTA CSLVLLGHIF YVLGNHRESN NMVVPAMQLA SKIPDMSVQL WSSALLRDLN
     KACGNNIDAH EAAQMHQNFS QQLLQDHIEA CSLPEHNLIT WTDGSPPVQF QAQNGPTTSL
     ASLL