SCD2_SCHPO
ID SCD2_SCHPO Reviewed; 536 AA.
AC P40996;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 162.
DE RecName: Full=Protein scd2/ral3;
GN Name=scd2; Synonyms=ral3; ORFNames=SPAC22H10.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SP870;
RX PubMed=7923372; DOI=10.1016/0092-8674(94)90406-5;
RA Chang E.C., Barr M., Wang Y., Jung V., Xu H.-P., Wigler M.H.;
RT "Cooperative interaction of S. pombe proteins required for mating and
RT morphogenesis.";
RL Cell 79:131-141(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for mating and morphogenesis. Interacts directly
CC with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42
CC interactions.
CC -!- SUBUNIT: Scd1, scd2, cdc42, and ras1, in its GTP-bound state, act
CC cooperatively to form a protein complex.
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DR EMBL; U12539; AAA50557.1; -; Genomic_DNA.
DR EMBL; CU329670; CAA93608.1; -; Genomic_DNA.
DR PIR; T38210; T38210.
DR RefSeq; NP_593744.1; NM_001019175.2.
DR AlphaFoldDB; P40996; -.
DR SMR; P40996; -.
DR BioGRID; 278220; 12.
DR MINT; P40996; -.
DR STRING; 4896.SPAC22H10.07.1; -.
DR iPTMnet; P40996; -.
DR MaxQB; P40996; -.
DR PaxDb; P40996; -.
DR PRIDE; P40996; -.
DR EnsemblFungi; SPAC22H10.07.1; SPAC22H10.07.1:pep; SPAC22H10.07.
DR GeneID; 2541726; -.
DR KEGG; spo:SPAC22H10.07; -.
DR PomBase; SPAC22H10.07; scd2.
DR VEuPathDB; FungiDB:SPAC22H10.07; -.
DR eggNOG; KOG4773; Eukaryota.
DR HOGENOM; CLU_014957_0_1_1; -.
DR InParanoid; P40996; -.
DR OMA; YWYIIEA; -.
DR PhylomeDB; P40996; -.
DR Reactome; R-SPO-5668599; RHO GTPases Activate NADPH Oxidases.
DR Reactome; R-SPO-8941237; Invadopodia formation.
DR PRO; PR:P40996; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0071521; C:Cdc42 GTPase complex; TAS:PomBase.
DR GO; GO:0032153; C:cell division site; IDA:PomBase.
DR GO; GO:0051286; C:cell tip; HDA:PomBase.
DR GO; GO:0090726; C:cortical dynamic polarity patch; IDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0043332; C:mating projection tip; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0031520; C:plasma membrane of cell tip; EXP:PomBase.
DR GO; GO:0035091; F:phosphatidylinositol binding; ISM:PomBase.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IPI:PomBase.
DR GO; GO:0000902; P:cell morphogenesis; IEA:InterPro.
DR GO; GO:0000747; P:conjugation with cellular fusion; IBA:GO_Central.
DR GO; GO:0071963; P:establishment or maintenance of cell polarity regulating cell shape; IMP:PomBase.
DR GO; GO:1902917; P:positive regulation of mating projection assembly; IMP:PomBase.
DR GO; GO:0031137; P:regulation of conjugation with cellular fusion; IMP:PomBase.
DR GO; GO:2000769; P:regulation of establishment or maintenance of cell polarity regulating cell shape; IMP:PomBase.
DR GO; GO:1901901; P:regulation of protein localization to cell division site involved in cytokinesis; IMP:PomBase.
DR CDD; cd06890; PX_Bem1p; 1.
DR CDD; cd11878; SH3_Bem1p_1; 1.
DR CDD; cd11879; SH3_Bem1p_2; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR030507; Bem1/Scd2.
DR InterPro; IPR035550; Bem1/Scd2_PX.
DR InterPro; IPR035548; Bem1/Scd2_SH3_1.
DR InterPro; IPR035549; Bem1/Scd2_SH3_2.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15706:SF2; PTHR15706:SF2; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 2.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF50044; SSF50044; 2.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome; Repeat; SH3 domain.
FT CHAIN 1..536
FT /note="Protein scd2/ral3"
FT /id="PRO_0000097620"
FT DOMAIN 24..86
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 123..185
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 293..413
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT DOMAIN 459..533
FT /note="PB1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT REGION 88..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 536 AA; 60043 MW; 7B86BA8CB32D1762 CRC64;
MLKIKRTWKT HSRILDKDPF SIEPPRKVIR ALYDYTARKA TEVSFAKGDF FHVIGRENDK
AWYEVCNPAA GTRGFVPVSH FEEIGKTVKS ERDSDGSGQI SFTDLTTNSS TTRSSISELH
SGSQPLFGIV QFDFAAERPD ELEAKAGEAI IIIARSNHEW LVAKPIGRLG GPGLIPLSFI
QLRDLKTGAV IKDVSEAVLR ISCIPRVEDW KRAAADYKKS SIPLGKFSDG ETQTMPSLSP
STENLQINND VTYQAATDNS STFPGSVANE LTPLQTLESR TASIASKNKK DMSSEPTVVA
AMVENYMIRD DQYWYLVRAV MSDGKHRNLC RYYEDFFNFQ TKFLELFPNE AGRGDERRVI
PYMPGPVDDV NELISSQRAM DLDVYLKEMC RLPARLLENE LVKLFFLPLD GDVESPHPTS
TMPEALPREP LSFSLPEKAP EKATNISIPE SAPTTAGSTC KVKVRLGDET FALRVPSDIS
FEDFCERLTN KLGECEHLSY RDTNANKVLP LNNVDDLRKA CSQESGVLLF AERRRF
