SCDA_STAA1
ID SCDA_STAA1 Reviewed; 224 AA.
AC A7WXS1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Iron-sulfur cluster repair protein ScdA {ECO:0000255|HAMAP-Rule:MF_01156};
GN Name=scdA {ECO:0000255|HAMAP-Rule:MF_01156}; OrderedLocusNames=SAHV_0258;
OS Staphylococcus aureus (strain Mu3 / ATCC 700698).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=418127;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu3 / ATCC 700698;
RX PubMed=17954695; DOI=10.1128/aac.00534-07;
RA Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.;
RT "Mutated response regulator graR is responsible for phenotypic conversion
RT of Staphylococcus aureus from heterogeneous vancomycin-intermediate
RT resistance to vancomycin-intermediate resistance.";
RL Antimicrob. Agents Chemother. 52:45-53(2008).
CC -!- FUNCTION: Di-iron-containing protein involved in the repair of iron-
CC sulfur clusters damaged by oxidative and nitrosative stress conditions.
CC {ECO:0000255|HAMAP-Rule:MF_01156}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01156}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01156}.
CC -!- SIMILARITY: Belongs to the RIC family. ScdA subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01156}.
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DR EMBL; AP009324; BAF77141.1; -; Genomic_DNA.
DR RefSeq; WP_000608818.1; NC_009782.1.
DR AlphaFoldDB; A7WXS1; -.
DR SMR; A7WXS1; -.
DR KEGG; saw:SAHV_0258; -.
DR HOGENOM; CLU_076075_0_1_9; -.
DR OMA; ACTTWRV; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030091; P:protein repair; IEA:UniProtKB-UniRule.
DR GO; GO:0051409; P:response to nitrosative stress; IEA:UniProtKB-UniRule.
DR GO; GO:0006979; P:response to oxidative stress; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3910.10; -; 1.
DR HAMAP; MF_01156; RIC_ScdA; 1.
DR InterPro; IPR012312; Hemerythrin-like.
DR InterPro; IPR019903; RIC_family.
DR InterPro; IPR023551; ScdA.
DR InterPro; IPR038062; ScdA-like_N_sf.
DR PANTHER; PTHR36438; PTHR36438; 1.
DR Pfam; PF01814; Hemerythrin; 1.
DR Pfam; PF04405; ScdA_N; 1.
DR SUPFAM; SSF140683; SSF140683; 1.
DR TIGRFAMs; TIGR03652; FeS_repair_RIC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Iron; Metal-binding; Stress response.
FT CHAIN 1..224
FT /note="Iron-sulfur cluster repair protein ScdA"
FT /id="PRO_1000065534"
SQ SEQUENCE 224 AA; 25468 MW; 056F55A750C2C712 CRC64;
MINKNDIVAD IVIDYPKAAD IFRSVGIDFC CGGQVSIEAA SLEKKNVDLN ELLQRLNDVE
QTNTPGSLNP KFLNVSSLIQ YIQAAYHEPL REEFKNLTPY VTKLSKVHGP NHPYLVELKE
TYDTFKSGML EHMQKEDDVD FPKLIKYEQG EVVNDINTVI DDLVSDHIAT GQLLVKMSDL
TSSYEPPIEA CGTWRLVYQR LKALEVLTHE HVHLENHVLF KKVS