ID   SCDA_STAEQ              Reviewed;         224 AA.
AC   Q5HR69;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Iron-sulfur cluster repair protein ScdA {ECO:0000255|HAMAP-Rule:MF_01156};
GN   Name=scdA {ECO:0000255|HAMAP-Rule:MF_01156}; OrderedLocusNames=SERP0324;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Di-iron-containing protein involved in the repair of iron-
CC       sulfur clusters damaged by oxidative and nitrosative stress conditions.
CC       {ECO:0000255|HAMAP-Rule:MF_01156}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01156}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01156}.
CC   -!- SIMILARITY: Belongs to the RIC family. ScdA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01156}.
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DR   EMBL; CP000029; AAW53686.1; -; Genomic_DNA.
DR   RefSeq; WP_001832101.1; NC_002976.3.
DR   AlphaFoldDB; Q5HR69; -.
DR   SMR; Q5HR69; -.
DR   STRING; 176279.SERP0324; -.
DR   EnsemblBacteria; AAW53686; AAW53686; SERP0324.
DR   GeneID; 50019405; -.
DR   KEGG; ser:SERP0324; -.
DR   eggNOG; COG2846; Bacteria.
DR   HOGENOM; CLU_076075_0_1_9; -.
DR   OMA; ACTTWRV; -.
DR   OrthoDB; 1701106at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030091; P:protein repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0051409; P:response to nitrosative stress; IEA:UniProtKB-UniRule.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3910.10; -; 1.
DR   HAMAP; MF_01156; RIC_ScdA; 1.
DR   InterPro; IPR012312; Hemerythrin-like.
DR   InterPro; IPR019903; RIC_family.
DR   InterPro; IPR023551; ScdA.
DR   InterPro; IPR038062; ScdA-like_N_sf.
DR   PANTHER; PTHR36438; PTHR36438; 1.
DR   Pfam; PF01814; Hemerythrin; 1.
DR   Pfam; PF04405; ScdA_N; 1.
DR   SUPFAM; SSF140683; SSF140683; 1.
DR   TIGRFAMs; TIGR03652; FeS_repair_RIC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Iron; Metal-binding; Reference proteome; Stress response.
FT   CHAIN           1..224
FT                   /note="Iron-sulfur cluster repair protein ScdA"
FT                   /id="PRO_0000220343"
SQ   SEQUENCE   224 AA;  25936 MW;  E37787339EF2188A CRC64;
     MITKEDIVAD VVTDYPKSAD IFRNAGIDFC CGGQESIASA VNHKPNIDLN SLLNKLNHID
     NTEGNSTINP KFLNVESLIQ YIQSAYHETL KEEFKNLTPY MTKLAKVHGP SHPYLLKLQD
     LYREFRDSML DHIRKEDEED FPKLIQYSQG QDVQNIKIIL EDLINDHEDT GQLLNVMNQL
     TSDYQTPEEA CGTWKLVYQR LQNIERQTHQ HVHLENHVLF KKVS