ID   SCDA_STAHJ              Reviewed;         222 AA.
AC   Q4L8T8;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Iron-sulfur cluster repair protein ScdA;
GN   Name=scdA; OrderedLocusNames=SH0628;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Di-iron-containing protein involved in the repair of iron-
CC       sulfur clusters damaged by oxidative and nitrosative stress conditions.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RIC family. ScdA subfamily. {ECO:0000305}.
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DR   EMBL; AP006716; BAE03937.1; -; Genomic_DNA.
DR   RefSeq; WP_011274953.1; NC_007168.1.
DR   AlphaFoldDB; Q4L8T8; -.
DR   SMR; Q4L8T8; -.
DR   STRING; 279808.SH0628; -.
DR   EnsemblBacteria; BAE03937; BAE03937; SH0628.
DR   GeneID; 58063180; -.
DR   KEGG; sha:SH0628; -.
DR   eggNOG; COG2846; Bacteria.
DR   HOGENOM; CLU_076075_0_1_9; -.
DR   OMA; ACTTWRV; -.
DR   OrthoDB; 1701106at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030091; P:protein repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0051409; P:response to nitrosative stress; IEA:UniProtKB-UniRule.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3910.10; -; 1.
DR   InterPro; IPR012312; Hemerythrin-like.
DR   InterPro; IPR019903; RIC_family.
DR   InterPro; IPR023551; ScdA.
DR   InterPro; IPR038062; ScdA-like_N_sf.
DR   PANTHER; PTHR36438; PTHR36438; 1.
DR   Pfam; PF01814; Hemerythrin; 1.
DR   Pfam; PF04405; ScdA_N; 1.
DR   SUPFAM; SSF140683; SSF140683; 1.
DR   TIGRFAMs; TIGR03652; FeS_repair_RIC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Iron; Metal-binding; Stress response.
FT   CHAIN           1..222
FT                   /note="Iron-sulfur cluster repair protein ScdA"
FT                   /id="PRO_0000406191"
SQ   SEQUENCE   222 AA;  25829 MW;  160B35553FF4E13C CRC64;
     MITNESIVAE IVTDIPLSAD IFRKYGIDFC CGGNISINEA VKNKKVDAET LIDEINELPN
     HDQGNINVKY LDAPSLIQYI QSRYHETMRE EFKNLSPYVT KVAKVHGPNH PFLIQLQDLY
     RQYRDGMLEH MAQEDEHDFP ALIKLSRGEQ VDHSSDIIQS LVDDHTQTGQ LLEDMRELTS
     QYQPPSEACQ TWRLVYHRLM NLERETHEHV HLENHVLFNK FS