ID   SCED_STAES              Reviewed;         219 AA.
AC   Q8CMK7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable transglycosylase SceD;
DE            EC=3.2.-.-;
DE   Flags: Precursor;
GN   Name=sceD; OrderedLocusNames=SE_1694;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Is able to cleave peptidoglycan and affects clumping and
CC       separation of bacterial cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transglycosylase family. SceD subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE015929; AAO05293.1; -; Genomic_DNA.
DR   RefSeq; NP_765249.1; NC_004461.1.
DR   RefSeq; WP_001829904.1; NZ_WBME01000021.1.
DR   AlphaFoldDB; Q8CMK7; -.
DR   SMR; Q8CMK7; -.
DR   STRING; 176280.SE_1694; -.
DR   CAZy; GH23; Glycoside Hydrolase Family 23.
DR   EnsemblBacteria; AAO05293; AAO05293; SE_1694.
DR   GeneID; 50018206; -.
DR   KEGG; sep:SE_1694; -.
DR   PATRIC; fig|176280.10.peg.1654; -.
DR   eggNOG; COG1388; Bacteria.
DR   HOGENOM; CLU_099865_0_0_9; -.
DR   OMA; AGPSQWV; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd13925; RPF; 1.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR010618; RPF.
DR   Pfam; PF06737; Transglycosylas; 1.
DR   SUPFAM; SSF53955; SSF53955; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..219
FT                   /note="Probable transglycosylase SceD"
FT                   /id="PRO_0000320319"
FT   REGION          86..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   219 AA;  23056 MW;  7BCCEF11B838E78C CRC64;
     MKKTLVASSL AIGLGVVAGN AGHDAHASET TNVDKAELAQ KALTNDQSLN ESPVQEGAYN
     INFDYNGNSY HFESDGSTWS WSYESTNNAT QPVQPSQSQV ATQQQPVQVS APQNEQTAQP
     QTKSTSTSQT SSSKASSGSS VNVNSHLQQI AQRESGGDIH AINPSSGAAG KYQFLQSTWD
     SVAPSQYKGV SPAKAPESVQ DRAAVKLYNT GGPGHWVTA