SCFD2_MOUSE
ID SCFD2_MOUSE Reviewed; 684 AA.
AC Q8BTY8; Q3USN5; Q8BFV9; Q8BKU5; Q8BKZ0; Q8BTP6; Q8BTQ9; Q8BXI1; Q8BXS0;
AC Q8BZ58;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Sec1 family domain-containing protein 2;
DE AltName: Full=Neuronal Sec1;
DE AltName: Full=Syntaxin-binding protein 1-like 1;
GN Name=Scfd2; Synonyms=Stxbp1l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Bone, Cerebellum, Corpora quadrigemina, Corpus striatum, Embryo,
RC Ovary, Retina, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=NMRI; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in protein transport. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8BTY8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BTY8-2; Sequence=VSP_010714;
CC Name=3;
CC IsoId=Q8BTY8-3; Sequence=VSP_010712, VSP_010713;
CC Name=4;
CC IsoId=Q8BTY8-4; Sequence=VSP_010711, VSP_010712, VSP_010713;
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC32943.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC34373.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK036637; BAC29514.1; -; mRNA.
DR EMBL; AK044408; BAC31906.1; -; mRNA.
DR EMBL; AK047026; BAC32943.1; ALT_INIT; mRNA.
DR EMBL; AK047738; BAC33143.1; -; mRNA.
DR EMBL; AK050673; BAC34373.1; ALT_INIT; mRNA.
DR EMBL; AK054548; BAC35820.1; -; mRNA.
DR EMBL; AK088353; BAC40298.1; -; mRNA.
DR EMBL; AK089011; BAC40699.1; -; mRNA.
DR EMBL; AK140246; BAE24296.1; -; mRNA.
DR EMBL; BC042528; AAH42528.1; -; mRNA.
DR CCDS; CCDS19345.1; -. [Q8BTY8-3]
DR CCDS; CCDS51519.1; -. [Q8BTY8-1]
DR CCDS; CCDS71603.1; -. [Q8BTY8-2]
DR RefSeq; NP_001108132.1; NM_001114660.2. [Q8BTY8-1]
DR RefSeq; NP_001273366.1; NM_001286437.1. [Q8BTY8-2]
DR RefSeq; NP_848787.2; NM_178672.7. [Q8BTY8-3]
DR AlphaFoldDB; Q8BTY8; -.
DR STRING; 10090.ENSMUSP00000072636; -.
DR iPTMnet; Q8BTY8; -.
DR PhosphoSitePlus; Q8BTY8; -.
DR EPD; Q8BTY8; -.
DR MaxQB; Q8BTY8; -.
DR PaxDb; Q8BTY8; -.
DR PeptideAtlas; Q8BTY8; -.
DR PRIDE; Q8BTY8; -.
DR ProteomicsDB; 256744; -. [Q8BTY8-1]
DR ProteomicsDB; 256745; -. [Q8BTY8-2]
DR ProteomicsDB; 256746; -. [Q8BTY8-3]
DR ProteomicsDB; 256747; -. [Q8BTY8-4]
DR Antibodypedia; 23902; 81 antibodies from 20 providers.
DR DNASU; 212986; -.
DR Ensembl; ENSMUST00000072857; ENSMUSP00000072636; ENSMUSG00000062110. [Q8BTY8-1]
DR Ensembl; ENSMUST00000075848; ENSMUSP00000075245; ENSMUSG00000062110. [Q8BTY8-3]
DR Ensembl; ENSMUST00000113542; ENSMUSP00000109170; ENSMUSG00000062110. [Q8BTY8-2]
DR Ensembl; ENSMUST00000151474; ENSMUSP00000121098; ENSMUSG00000062110. [Q8BTY8-3]
DR GeneID; 212986; -.
DR KEGG; mmu:212986; -.
DR UCSC; uc008xtk.3; mouse. [Q8BTY8-1]
DR UCSC; uc012dxh.2; mouse. [Q8BTY8-2]
DR CTD; 152579; -.
DR MGI; MGI:2443446; Scfd2.
DR VEuPathDB; HostDB:ENSMUSG00000062110; -.
DR eggNOG; ENOG502QQIB; Eukaryota.
DR GeneTree; ENSGT00390000011192; -.
DR HOGENOM; CLU_027230_1_0_1; -.
DR InParanoid; Q8BTY8; -.
DR OMA; CPFSPRV; -.
DR OrthoDB; 277043at2759; -.
DR PhylomeDB; Q8BTY8; -.
DR TreeFam; TF329842; -.
DR BioGRID-ORCS; 212986; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Scfd2; mouse.
DR PRO; PR:Q8BTY8; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8BTY8; protein.
DR Bgee; ENSMUSG00000062110; Expressed in animal zygote and 146 other tissues.
DR ExpressionAtlas; Q8BTY8; baseline and differential.
DR Genevisible; Q8BTY8; MM.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.1910; -; 1.
DR InterPro; IPR001619; Sec1-like.
DR InterPro; IPR027482; Sec1-like_dom2.
DR InterPro; IPR036045; Sec1-like_sf.
DR PANTHER; PTHR11679; PTHR11679; 1.
DR Pfam; PF00995; Sec1; 1.
DR SUPFAM; SSF56815; SSF56815; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Protein transport; Reference proteome; Transport.
FT CHAIN 1..684
FT /note="Sec1 family domain-containing protein 2"
FT /id="PRO_0000206291"
FT VAR_SEQ 1..143
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010711"
FT VAR_SEQ 438..477
FT /note="SLGDSTMAGVLNQLLPMIKSSSQRTSDDLNPEELLILLIY -> CSFVLRAC
FT GHLLHSCHGTMLPPVPRQPPWVHPPHGCPFIP (in isoform 3 and isoform
FT 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_010712"
FT VAR_SEQ 478..684
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_010713"
FT VAR_SEQ 615..654
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010714"
FT CONFLICT 89
FT /note="L -> V (in Ref. 1; BAC29514)"
FT /evidence="ECO:0000305"
FT CONFLICT 234
FT /note="E -> G (in Ref. 1; BAC31906/BAC34373)"
FT /evidence="ECO:0000305"
FT CONFLICT 368
FT /note="S -> R (in Ref. 1; BAC29514)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 684 AA; 74751 MW; 96F00899480022D5 CRC64;
MSAAGILAFA QQGWEQVLAK VKWSVVYLDA ACAESLHWSC GSSRLLEAVK GPACHLREFE
PQAIGGGAKQ PRAVFVLSSP LKGRIVDTLQ SIICRSHFQH CVVVTAVSHA VHLTANHVPA
AAAAELEGQQ PVFEQLEEKL CEWMGNENYT AEVLHVPLFL APVASHLAFT PAFATLFPLL
PQDVHALNSA RPDKRRLSSL GEVDATALTP ELLLYIRCLV SGLSSLCEHL GVREECFAVG
PLSRVIATDL ANYAPAKNRK KTATGRASVV FVDRTLDLTG AVGHHGDNLV EKIMSVLPQL
PGHTHDVMVN MAELTAVQAV EENQNVIAPG CLAPSNEASA KALWEALLNS KHKEAVMEVR
RHLVEAASRE NLPIKMSMGR VTPGQLMSYI QLFKNNLRAL RNHCGLLQLG MATVQTLKHP
QTAKWDNFLA FERLLLQSLG DSTMAGVLNQ LLPMIKSSSQ RTSDDLNPEE LLILLIYIYS
VPGDVTLDRD LGDVEEKVKK ALAHVLSEES ELSPLLQKIT GCDSAVDLTL PKSQIAVNDV
FMALREIAGA RNLMRQFKSV YVPGNNTHQA SYKPLLKQVV EEIFNPEKSD PIDIEHMSSG
LTDLLKTGFS MFMKVSRPHP SDHPLLILFV VGGVTVAEAK MVKDLVASLK PGTQVMVLST
RLLKPLNIPE LLFATDRLHP DLGF
