SCF_CHICK
ID SCF_CHICK Reviewed; 287 AA.
AC Q09108;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Kit ligand;
DE AltName: Full=Mast cell growth factor;
DE Short=MGF;
DE AltName: Full=Stem cell factor;
DE Short=SCF;
DE AltName: Full=c-Kit ligand;
DE Contains:
DE RecName: Full=Processed kit ligand;
DE Flags: Precursor;
GN Name=KITLG; Synonyms=SCF;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7684722; DOI=10.1016/0378-1119(93)90732-i;
RA Zhou J., Ohtaki M., Sakurai M.;
RT "Sequence of a cDNA encoding chicken stem cell factor.";
RL Gene 127:269-270(1993).
CC -!- FUNCTION: Ligand for the receptor-type protein-tyrosine kinase KIT.
CC Plays an essential role in the regulation of cell survival and
CC proliferation, hematopoiesis, stem cell maintenance, gametogenesis,
CC mast cell development, migration and function, and in melanogenesis.
CC KITLG/SCF binding can activate several signaling pathways. Acts
CC synergistically with other cytokines, probably interleukins (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer, non-covalently linked. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P21583}.
CC Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane
CC {ECO:0000250|UniProtKB:P21583}; Single-pass type I membrane protein
CC {ECO:0000250}. Cell projection, lamellipodium
CC {ECO:0000250|UniProtKB:P21583}. Cell projection, filopodium
CC {ECO:0000250|UniProtKB:P21583}.
CC -!- SUBCELLULAR LOCATION: [Processed kit ligand]: Secreted {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Acts in the early stages of hematopoiesis.
CC -!- PTM: A soluble form is produced by proteolytic processing of the
CC extracellular domain. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SCF family. {ECO:0000305}.
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DR EMBL; D13516; BAA02733.1; -; mRNA.
DR PIR; JN0637; JN0637.
DR RefSeq; NP_990461.1; NM_205130.1.
DR AlphaFoldDB; Q09108; -.
DR SMR; Q09108; -.
DR STRING; 9031.ENSGALP00000042694; -.
DR PaxDb; Q09108; -.
DR Ensembl; ENSGALT00000018268; ENSGALP00000018246; ENSGALG00000011206.
DR GeneID; 396028; -.
DR KEGG; gga:396028; -.
DR CTD; 4254; -.
DR VEuPathDB; HostDB:geneid_396028; -.
DR eggNOG; ENOG502QTGT; Eukaryota.
DR GeneTree; ENSGT00390000018272; -.
DR InParanoid; Q09108; -.
DR OMA; CWISVMV; -.
DR OrthoDB; 1083457at2759; -.
DR PhylomeDB; Q09108; -.
DR TreeFam; TF330811; -.
DR Reactome; R-GGA-1257604; PIP3 activates AKT signaling.
DR Reactome; R-GGA-1433557; Signaling by SCF-KIT.
DR Reactome; R-GGA-1433559; Regulation of KIT signaling.
DR Reactome; R-GGA-5673001; RAF/MAP kinase cascade.
DR Reactome; R-GGA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR PRO; PR:Q09108; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000011206; Expressed in heart and 12 other tissues.
DR ExpressionAtlas; Q09108; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005173; F:stem cell factor receptor binding; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR003452; SCF.
DR PANTHER; PTHR11574; PTHR11574; 1.
DR Pfam; PF02404; SCF; 1.
DR PIRSF; PIRSF015599; SCF; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Cell membrane; Cell projection; Cytoplasm; Cytoskeleton;
KW Disulfide bond; Glycoprotein; Growth factor; Membrane; Reference proteome;
KW Secreted; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..287
FT /note="Kit ligand"
FT /id="PRO_0000031919"
FT CHAIN 26..?
FT /note="Processed kit ligand"
FT /id="PRO_0000292279"
FT TOPO_DOM 26..225
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 29..117
FT /evidence="ECO:0000250"
FT DISULFID 68..167
FT /evidence="ECO:0000250"
SQ SEQUENCE 287 AA; 32328 MW; 6AE8556ADC152578 CRC64;
MKKAQTWIIT CFCLQLLLLN PLVKAQSSCG NPVTDDVNDI AKLVGNLPND YLITLKYVPK
MDSLPNHCWL HLMVPEFSRS LHNLLQKFSD ISDMSDVLSN YSIINNLTRI INDLMACLAF
DKNKDFIKEN GHLYEEDRFI PENFFRLFNS TIEVYKEFAD SLDKNDCIMP STVETPENDS
RVAVTKTISF PPVAASSLRN DSIGSNTSSN SNKEALGFIS SSSLQGISIA LTSLLSLLIG
FILGAIYWKK THPKSRPESN ETIQCHGCQE ENEISMLQQK EKEHLQV
