ID   SCG2_MACFA              Reviewed;         617 AA.
AC   Q4R5E9;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Secretogranin-2;
DE   AltName: Full=Secretogranin II;
DE            Short=SgII;
DE   Contains:
DE     RecName: Full=Secretoneurin;
DE              Short=SN;
DE   Contains:
DE     RecName: Full=Manserin;
DE   Flags: Precursor;
GN   Name=SCG2; ORFNames=QnpA-15483;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Parietal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Neuroendocrine protein of the granin family that regulates
CC       the biogenesis of secretory granules. {ECO:0000250|UniProtKB:P13521}.
CC   -!- SUBUNIT: Interacts with Secretogranin III/SCG3.
CC       {ECO:0000250|UniProtKB:P13521}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=Neuroendocrine and endocrine
CC       secretory granules. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Binds calcium with a low-affinity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chromogranin/secretogranin protein family.
CC       {ECO:0000305}.
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DR   EMBL; AB169594; BAE01676.1; -; mRNA.
DR   RefSeq; NP_001271543.1; NM_001284614.1.
DR   AlphaFoldDB; Q4R5E9; -.
DR   SMR; Q4R5E9; -.
DR   STRING; 9541.XP_005574491.1; -.
DR   GeneID; 101866139; -.
DR   CTD; 7857; -.
DR   eggNOG; ENOG502QV5W; Eukaryota.
DR   OrthoDB; 587478at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR   InterPro; IPR018054; Chromogranin_CS.
DR   InterPro; IPR001990; Granin.
DR   InterPro; IPR038858; ScgII.
DR   PANTHER; PTHR15119; PTHR15119; 1.
DR   Pfam; PF01271; Granin; 1.
DR   PROSITE; PS00422; GRANINS_1; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cleavage on pair of basic residues; Phosphoprotein;
KW   Reference proteome; Secreted; Signal; Sulfation.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   PROPEP          28..30
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000352311"
FT   CHAIN           31..617
FT                   /note="Secretogranin-2"
FT                   /id="PRO_0000352312"
FT   PEPTIDE         182..214
FT                   /note="Secretoneurin"
FT                   /id="PRO_0000352313"
FT   PEPTIDE         527..566
FT                   /note="Manserin"
FT                   /evidence="ECO:0000250|UniProtKB:P10362"
FT                   /id="PRO_0000432736"
FT   REGION          123..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          552..583
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         151
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P13521"
FT   MOD_RES         174
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P10362"
FT   MOD_RES         268
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P10362"
FT   MOD_RES         432
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P10362"
FT   MOD_RES         532
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q03517"
FT   MOD_RES         555
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q03517"
FT   MOD_RES         556
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q03517"
SQ   SEQUENCE   617 AA;  70918 MW;  308AFA0EABD45CED CRC64;
     MAEAKTHWLG AALSLIPLIF LISGAEAASF QRNQLLQKEP DLRLENVQKF PSPEMIRALE
     YIEKLRQQAH KEESSPDYNP YQGVSIPLQQ KENGDESHLP ERDSLSEEDW MRIILEALRQ
     VENEPQSVPK ENKPHALNSE KNFPIDMSDD YETQQWPERK LKHMQFPPMY EENSRDNPFK
     RTNEIVEEQY TPQSLATLES VFQELGKLTG PNNQKRERMD EEQKLYTDDE DDIYKANNIA
     YEDVVGGEDW NPVEEKIESQ TQEEVRDSKE NTEKNEQIND EVKRSGQLGI QEEDLRKESK
     DQLSDDVSKV ITYLKRLVNA AGSGRLQNGQ NGERATRLFE KPLDSQSIYQ LIEISRNLQI
     PPEDLIEMLK TGEKPNGSVE PERELDLPVD LDDISEADLD HPDLFQNKML SKSGYPKTVG
     RAGTEALPDG LSVEDILNLL GMESAANQKT SYFPNPYNQE KVLPRLPYGP GRSRSNQLPK
     AAWMPYVENR QMAYENLNDK DQELGEYLAR MLVKYPEIIN SNQVKRVPGQ GSPEDDLQEE
     EQIEQAIKEH LNQGSSQETD KLAPVSKRFP VGPPKNDDTP NRQYLDEDLL TKVLEYLNQE
     KAEKGREHIA KRAMENM