SCG3_DANRE
ID SCG3_DANRE Reviewed; 478 AA.
AC A3KQQ9; Q6PBU8;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Secretogranin-3;
DE AltName: Full=Secretogranin III;
DE Short=SgIII;
DE Flags: Precursor;
GN Name=scg3; ORFNames=si:ch211-12a1.3, zgc:73236;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle lumen
CC {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted
CC {ECO:0000250}. Note=Associated with the secretory granule membrane
CC through direct binding to cholesterol-enriched lipid rafts in
CC intragranular conditions. {ECO:0000250}.
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DR EMBL; BX927313; CAM56318.1; -; Genomic_DNA.
DR EMBL; BC059577; AAH59577.1; -; mRNA.
DR RefSeq; NP_957051.1; NM_200757.1.
DR AlphaFoldDB; A3KQQ9; -.
DR SMR; A3KQQ9; -.
DR STRING; 7955.ENSDARP00000105698; -.
DR PaxDb; A3KQQ9; -.
DR PeptideAtlas; A3KQQ9; -.
DR PRIDE; A3KQQ9; -.
DR Ensembl; ENSDART00000122930; ENSDARP00000105698; ENSDARG00000086288.
DR GeneID; 393730; -.
DR KEGG; dre:393730; -.
DR CTD; 29106; -.
DR ZFIN; ZDB-GENE-040426-1725; scg3.
DR eggNOG; ENOG502QUJH; Eukaryota.
DR GeneTree; ENSGT00390000005488; -.
DR HOGENOM; CLU_031198_1_0_1; -.
DR InParanoid; A3KQQ9; -.
DR OMA; MEKEYEI; -.
DR OrthoDB; 692526at2759; -.
DR TreeFam; TF331266; -.
DR Reactome; R-DRE-114608; Platelet degranulation.
DR Reactome; R-DRE-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR Reactome; R-DRE-8957275; Post-translational protein phosphorylation.
DR PRO; PR:A3KQQ9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 18.
DR Bgee; ENSDARG00000086288; Expressed in brain and 20 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030667; C:secretory granule membrane; IBA:GO_Central.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033366; P:protein localization to secretory granule; IBA:GO_Central.
DR InterPro; IPR026197; SCG3.
DR PANTHER; PTHR17388; PTHR17388; 1.
DR Pfam; PF15467; SGIII; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Cytoplasmic vesicle; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..478
FT /note="Secretogranin-3"
FT /id="PRO_0000417023"
FT REGION 22..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..256
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 18..20
FT /note="HIN -> DIS (in Ref. 2; AAH59577)"
FT /evidence="ECO:0000305"
FT CONFLICT 106
FT /note="T -> A (in Ref. 2; AAH59577)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 478 AA; 53995 MW; 31688E409CA82429 CRC64;
MASKRLGFVV VLALVCQHIN AFPTPAGPDD KYNRELTEEK PLEQQIAEAD SIRKTESKPT
PPAEEETNSE DDDITFLKAL AEKSKESNNE TPISDSANER LGADDTDSTK NRRLADDYDS
TKNGMDYKYQ DDPESFRQLD GTPLTAQDIV QKIANKIYEE DDRGVFDRIV SKLLKLGLIT
DSQAETLEYE VAEALQDLIT KNAKDNMIGD RSVDYPVSAA KDTQDEEDRP SPRFDEEDEV
ENEGGDDANG DEPQEEESRD DTVRSDDSWD AVSDGNDRNE LNPEDGLQDL QFFPNFYRLL
KSLDSEQDKE ERETLITIMK TLIDFVKMMV KYGTITPEEG VTYLENLDAM IALQTKNKLG
KSLVPLSITP PTGKAADDDD NTKTEAAKMQ KEYESLKDST KDVQTAAEIS HPGKSESYLE
AIRKNIEWLK KHNKEGNKED YDLSKLRDFM DQQVDSYIDK GILEKDEGDV IKRIYGSL
