SCG3_XENTR
ID SCG3_XENTR Reviewed; 463 AA.
AC F7E728; A4IIY0; A7MC32;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 2.
DT 03-AUG-2022, entry version 40.
DE RecName: Full=Secretogranin-3;
DE AltName: Full=Secretogranin III;
DE Short=SgIII;
DE Flags: Precursor;
GN Name=scg3;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-395 (ISOFORMS 1 AND 2).
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Member of the granin protein family that regulates the
CC biogenesis of secretory granules (By similarity). Acts as a sorting
CC receptor for intragranular proteins including chromogranin A/CHGA (By
CC similarity). May also play a role in angiogenesis. Promotes endothelial
CC proliferation, migration and tube formation through MEK/ERK signaling
CC pathway (By similarity). {ECO:0000250|UniProtKB:P47868,
CC ECO:0000250|UniProtKB:Q8WXD2}.
CC -!- SUBUNIT: Interacts with CHGA (By similarity). Interacts with
CC secretogranin II/SCG2 (By similarity). Interacts (via C-terminus) with
CC CPE (By similarity). {ECO:0000250|UniProtKB:P47867,
CC ECO:0000250|UniProtKB:Q8WXD2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle
CC {ECO:0000250|UniProtKB:P47868}. Cytoplasmic vesicle, secretory vesicle
CC membrane {ECO:0000250|UniProtKB:P47868}; Peripheral membrane protein.
CC Secreted {ECO:0000250|UniProtKB:Q8WXD2}. Note=Associated with the
CC secretory granule membrane through direct binding to cholesterol-
CC enriched lipid rafts. {ECO:0000250|UniProtKB:P47868}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F7E728-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F7E728-2; Sequence=VSP_043175;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI36198.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=AAI52025.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AAMC01056589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01056590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01056591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136197; AAI36198.1; ALT_SEQ; mRNA.
DR EMBL; BC152024; AAI52025.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001263622.1; NM_001276693.1.
DR RefSeq; NP_001263623.1; NM_001276694.1.
DR AlphaFoldDB; F7E728; -.
DR SMR; F7E728; -.
DR STRING; 8364.ENSXETP00000052912; -.
DR PaxDb; F7E728; -.
DR GeneID; 100125084; -.
DR KEGG; xtr:100125084; -.
DR CTD; 29106; -.
DR Xenbase; XB-GENE-966935; scg3.
DR eggNOG; ENOG502QUJH; Eukaryota.
DR HOGENOM; CLU_031198_1_0_1; -.
DR InParanoid; F7E728; -.
DR OrthoDB; 692526at2759; -.
DR Reactome; R-XTR-114608; Platelet degranulation.
DR Reactome; R-XTR-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR Reactome; R-XTR-8957275; Post-translational protein phosphorylation.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030667; C:secretory granule membrane; IBA:GO_Central.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033366; P:protein localization to secretory granule; IBA:GO_Central.
DR InterPro; IPR026197; SCG3.
DR PANTHER; PTHR17388; PTHR17388; 1.
DR Pfam; PF15467; SGIII; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cleavage on pair of basic residues;
KW Cytoplasmic vesicle; Membrane; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..463
FT /note="Secretogranin-3"
FT /id="PRO_0000417024"
FT REGION 87..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 353
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_043175"
FT CONFLICT 234
FT /note="E -> G (in Ref. 2; AAI36198)"
FT /evidence="ECO:0000305"
FT CONFLICT 392..394
FT /note="DKP -> KKK (in Ref. 2; AAI36198/AAI52025)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 463 AA; 52476 MW; F2883301A1224267 CRC64;
MGPKYVFITA IIGVFWHVQG FPNPGIKQDK AVHNRELSEE RPLEEQIAEA DTVSRGTSKE
NQEMLKNDSF ADELGLLMSV AEKEGDVKRS GSVRSSVGGH RGTLDDADST KNLKPAEYFD
STKSMLDYKY EDDPDGLHQL DGTPLTAEDI VRKIATRIYE ENDRGVFDKI VSKLLNLGLI
TESQAYTLED EVAEVLQQLI ANEAKNREKE AGDLDYAAVR SDVYDDDKQE GKMETRNKNE
DRESSETKNE DSFSSKERRN ELSPEEDFDD LQYFPNFNRL IKSLNSENDA KEKKTLITIM
KTLIDFVKMM VKYGTITPEE GVNYLENLDA MIAVQAKNKL GKSFGSHKSI LSEDKNVDES
DSTKQEAAKM EKEYEALKDS TKPEPKDAED KDKPKGKAET YLEAIRKNIE WLKEHNKEGN
KGVSDNDLSK LKDFINQQAD SYVEKGILDK EEANVIKRIY SSL
