ID   SCGR8_HUMAN             Reviewed;         108 AA.
AC   A0A286YFG1;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2017, sequence version 1.
DT   03-AUG-2022, entry version 15.
DE   RecName: Full=Small cysteine and glycine repeat-containing protein 8 {ECO:0000305};
DE   AltName: Full=Keratin-associated protein 28-8 {ECO:0000303|PubMed:18721477};
GN   Name=SCYGR8 {ECO:0000312|HGNC:HGNC:34227};
GN   Synonyms=KRTAP28-8 {ECO:0000303|PubMed:18721477};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   FAMILY CHARACTERIZATION.
RX   PubMed=18721477; DOI=10.1186/1471-2148-8-241;
RA   Wu D.D., Irwin D.M., Zhang Y.P.;
RT   "Molecular evolution of the keratin associated protein gene family in
RT   mammals, role in the evolution of mammalian hair.";
RL   BMC Evol. Biol. 8:241-241(2008).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Human have a similar number of genes as other primates
CC       despite the relative hairlessness of humans.
CC       {ECO:0000303|PubMed:18721477}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 28 family.
CC       {ECO:0000305|PubMed:18721477}.
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DR   EMBL; AC093762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A286YFG1; -.
DR   BioMuta; ENSG00000284635; -.
DR   MassIVE; A0A286YFG1; -.
DR   PeptideAtlas; A0A286YFG1; -.
DR   Ensembl; ENST00000641981.1; ENSP00000493156.1; ENSG00000284635.1.
DR   MANE-Select; ENST00000641981.2; ENSP00000493156.1; NM_001395409.1; NP_001382338.1.
DR   GeneCards; SCYGR8; -.
DR   HGNC; HGNC:34227; SCYGR8.
DR   HPA; ENSG00000284635; Not detected.
DR   neXtProt; NX_A0A286YFG1; -.
DR   VEuPathDB; HostDB:ENSG00000284635; -.
DR   GeneTree; ENSGT00950000183378; -.
DR   OMA; CCHRGYR; -.
DR   Pharos; A0A286YFG1; Tdark.
DR   PRO; PR:A0A286YFG1; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000284635; Expressed in skin of abdomen and 3 other tissues.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..108
FT                   /note="Small cysteine and glycine repeat-containing protein
FT                   8"
FT                   /id="PRO_0000445148"
FT   REGION          4..84
FT                   /note="12 X 2 AA repeats of CG"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   108 AA;  10123 MW;  5A0E264C84F361A9 CRC64;
     MGCCGCGGCG GGCGGCSGGC GGGCGGGCGG GGCGGGCGSC TTCRCYRVGC CSSCCPCCRG
     CCGGCCSTPV ICCCRRTCSS CGCGYGKGCC QQKGCCQQKC CCQKQCCC