ID   SCI1A_TOBAC             Reviewed;         154 AA.
AC   A0A1S4AX27; F8QMT0; F8QMT2;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2018, sequence version 2.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Style cell-cycle inhibitor 1-A {ECO:0000303|PubMed:21388377};
DE            Short=NtSCI1 {ECO:0000303|PubMed:21388377};
GN   Name=SCI1A {ECO:0000303|PubMed:21388377};
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR
RP   LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=cv. Petit Havana SR1;
RX   PubMed=21388377; DOI=10.1111/j.1469-8137.2011.03660.x;
RA   Depaoli H.C., Brito M.S., Quiapim A.C., Teixeira S.P., Goldman G.H.,
RA   Dornelas M.C., Goldman M.-H.S.;
RT   "Stigma/style cell cycle inhibitor 1 (SCI1), a tissue-specific cell cycle
RT   regulator that controls upper pistil development.";
RL   New Phytol. 190:882-895(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. TN90;
RX   PubMed=24807620; DOI=10.1038/ncomms4833;
RA   Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA   Goepfert S., Peitsch M.C., Ivanov N.V.;
RT   "The tobacco genome sequence and its comparison with those of tomato and
RT   potato.";
RL   Nat. Commun. 5:3833-3833(2014).
RN   [3]
RP   FUNCTION.
RX   PubMed=22301969; DOI=10.4161/psb.7.1.18525;
RA   DePaoli H.C., Goldman G.H., Goldman M.-H.S.;
RT   "SCI1, the first member of the tissue-specific inhibitors of CDK (TIC)
RT   class, is probably connected to the auxin signaling pathway.";
RL   Plant Signal. Behav. 7:53-58(2012).
CC   -!- FUNCTION: Component of the auxin signaling transduction pathway that
CC       regulates cell proliferation and differentiation during flowers stigmas
CC       and styles development (PubMed:21388377). Involved in the regulation of
CC       auxin-related genes (PubMed:22301969). {ECO:0000269|PubMed:21388377,
CC       ECO:0000269|PubMed:22301969}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21388377}.
CC       Note=Inside the nucleus, confined to the interchromatic region.
CC       {ECO:0000269|PubMed:21388377}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in flowers pistils,
CC       especially in stigmas and styles. Barely detected in roots, stems,
CC       leaves, sepals, petals and stamen. {ECO:0000269|PubMed:21388377}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at high levels at the early stages of
CC       pistil development (stages 1 to 6) and disappears towards anthesis
CC       (stages 7 to 12). At stage 4, observed in the stigmatic secretory zone,
CC       including the papillar cells, and in the stylar transmitting tissue.
CC       Expressed in stigma and style specialized tissues at initial stages of
CC       flower development. {ECO:0000269|PubMed:21388377}.
CC   -!- DISRUPTION PHENOTYPE: Enlarged stigmas and styles due to increased in
CC       cell numbers. {ECO:0000269|PubMed:21388377}.
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DR   EMBL; GQ272329; ADG60253.1; -; mRNA.
DR   EMBL; GQ272331; ADG60255.1; -; mRNA.
DR   AlphaFoldDB; A0A1S4AX27; -.
DR   OrthoDB; 1564723at2759; -.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051782; P:negative regulation of cell division; IMP:UniProtKB.
DR   GO; GO:0010928; P:regulation of auxin mediated signaling pathway; IMP:UniProtKB.
DR   GO; GO:0048480; P:stigma development; IMP:UniProtKB.
DR   GO; GO:0048479; P:style development; IMP:UniProtKB.
DR   InterPro; IPR044688; SCI-1-like.
DR   PANTHER; PTHR34117; PTHR34117; 1.
PE   2: Evidence at transcript level;
KW   Auxin signaling pathway; Cell cycle; Cell division; Developmental protein;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..154
FT                   /note="Style cell-cycle inhibitor 1-A"
FT                   /id="PRO_0000444450"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..44
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..65
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        23
FT                   /note="L -> R (in Ref. 1; ADG60253)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   154 AA;  18147 MW;  2E2A10C62B8B8DE9 CRC64;
     MGSDKKTPEE KRKHKRSSPS SPLDEVKSKR QNIKGDEERR KEKKDKSKKE KHKSHSSEEK
     KSGEKHKTKS HKHKDKSKNK FEELSKDDYF SKNNEFATWL KDKKNLFFSD LSSETARDLF
     SDFVIQWNKG KLDSQYYEGI ATGPRSSHAW NIKK