SCI1_ARATH
ID SCI1_ARATH Reviewed; 159 AA.
AC Q8GWY0; O64533; Q8LCI9;
DT 20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Style cell-cycle inhibitor 1 {ECO:0000303|PubMed:22301969};
DE Short=AtSCI1 {ECO:0000303|PubMed:25443839};
GN Name=SCI1 {ECO:0000303|PubMed:22301969};
GN OrderedLocusNames=At1g79200 {ECO:0000312|Araport:AT1G79200};
GN ORFNames=YUP8H12R.41 {ECO:0000312|EMBL:AAC17063.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION.
RX PubMed=22301969; DOI=10.4161/psb.7.1.18525;
RA DePaoli H.C., Goldman G.H., Goldman M.-H.S.;
RT "SCI1, the first member of the tissue-specific inhibitors of CDK (TIC)
RT class, is probably connected to the auxin signaling pathway.";
RL Plant Signal. Behav. 7:53-58(2012).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=25443839; DOI=10.1016/j.plantsci.2014.09.003;
RA DePaoli H.C., Dornelas M.C., Goldman M.H.S.;
RT "SCI1 is a component of the auxin-dependent control of cell proliferation
RT in Arabidopsis upper pistil.";
RL Plant Sci. 229:122-130(2014).
CC -!- FUNCTION: Component of the auxin signaling transduction pathway that
CC regulates cell proliferation and differentiation during flowers stigmas
CC and styles development (PubMed:25443839). Involved in the regulation of
CC auxin-related genes (PubMed:22301969, PubMed:25443839).
CC {ECO:0000269|PubMed:22301969, ECO:0000269|PubMed:25443839}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25443839}.
CC Note=Inside the nucleus, confined to the interchromatic region.
CC {ECO:0000250|UniProtKB:A0A1S4AX27}.
CC -!- DISRUPTION PHENOTYPE: Increased cell number in upper pistils leading to
CC enhanced stigmatic structure. Impaired siliques formation. Reduced
CC expression of auxin-related genes. {ECO:0000269|PubMed:25443839}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC17063.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002986; AAC17063.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE36214.1; -; Genomic_DNA.
DR EMBL; AK118564; BAC43165.1; -; mRNA.
DR EMBL; BT003682; AAO39910.1; -; mRNA.
DR EMBL; AY086579; AAM63641.1; -; mRNA.
DR PIR; T01037; T01037.
DR RefSeq; NP_565201.1; NM_106571.5.
DR AlphaFoldDB; Q8GWY0; -.
DR STRING; 3702.AT1G79200.1; -.
DR PaxDb; Q8GWY0; -.
DR PRIDE; Q8GWY0; -.
DR ProteomicsDB; 232910; -.
DR EnsemblPlants; AT1G79200.1; AT1G79200.1; AT1G79200.
DR GeneID; 844261; -.
DR Gramene; AT1G79200.1; AT1G79200.1; AT1G79200.
DR KEGG; ath:AT1G79200; -.
DR Araport; AT1G79200; -.
DR TAIR; locus:2207335; AT1G79200.
DR eggNOG; ENOG502S2GY; Eukaryota.
DR HOGENOM; CLU_141912_0_0_1; -.
DR InParanoid; Q8GWY0; -.
DR OMA; SAHKWNI; -.
DR OrthoDB; 1595815at2759; -.
DR PhylomeDB; Q8GWY0; -.
DR PRO; PR:Q8GWY0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8GWY0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0071365; P:cellular response to auxin stimulus; IGI:TAIR.
DR GO; GO:0048467; P:gynoecium development; IMP:TAIR.
DR GO; GO:0051782; P:negative regulation of cell division; ISS:UniProtKB.
DR GO; GO:0010928; P:regulation of auxin mediated signaling pathway; IMP:UniProtKB.
DR GO; GO:0048480; P:stigma development; IMP:UniProtKB.
DR GO; GO:0048479; P:style development; IMP:UniProtKB.
DR InterPro; IPR044688; SCI-1-like.
DR PANTHER; PTHR34117; PTHR34117; 1.
PE 2: Evidence at transcript level;
KW Auxin signaling pathway; Cell cycle; Cell division; Developmental protein;
KW Nucleus; Reference proteome.
FT CHAIN 1..159
FT /note="Style cell-cycle inhibitor 1"
FT /id="PRO_0000444449"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..62
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 2
FT /note="V -> G (in Ref. 5; AAM63641)"
FT /evidence="ECO:0000305"
FT CONFLICT 27
FT /note="E -> G (in Ref. 5; AAM63641)"
FT /evidence="ECO:0000305"
FT CONFLICT 143
FT /note="G -> R (in Ref. 5; AAM63641)"
FT /evidence="ECO:0000305"
FT CONFLICT 155
FT /note="M -> I (in Ref. 5; AAM63641)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 159 AA; 19087 MW; 304AC8085E73BEA3 CRC64;
MVSERSSKEK KRSRARSEDS SSSDYEEKVK RHRGTEKDDE RRSRRSDKKD KKSHKHHKSS
TSKKSKDDKP KKKHTESDHK LKEGIPELSM EDYFSKNNEF ATWLKEEKRT YFNDLTTEAA
RGLFSRFVKR WNRGKLESRY YEGISTAPRT AHDWMIKRR
