ID   SCIN_STAA8              Reviewed;         116 AA.
AC   Q2FWV6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Staphylococcal complement inhibitor;
DE            Short=SCIN;
DE   Flags: Precursor;
GN   Name=scn; OrderedLocusNames=SAOUHSC_02167;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   CHARACTERIZATION, AND SUBCELLULAR LOCATION.
RC   STRAIN=Cowan EMS;
RX   PubMed=16086019; DOI=10.1038/ni1235;
RA   Rooijakkers S.H.M., Ruyken M., Roos A., Daha M.R., Presanis J.S., Sim R.B.,
RA   van Wamel W.J.B., van Kessel K.P.M., van Strijp J.A.G.;
RT   "Immune evasion by a staphylococcal complement inhibitor that acts on C3
RT   convertases.";
RL   Nat. Immunol. 6:920-927(2005).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND INDUCTION.
RX   PubMed=16882032; DOI=10.1111/j.1462-5822.2006.00709.x;
RA   Rooijakkers S.H.M., Ruyken M., van Roon J., van Kessel K.P.M.,
RA   van Strijp J.A.G., van Wamel W.J.B.;
RT   "Early expression of SCIN and CHIPS drives instant immune evasion by
RT   Staphylococcus aureus.";
RL   Cell. Microbiol. 8:1282-1293(2006).
CC   -!- FUNCTION: Involved in countering the first line of host defense
CC       mechanisms. Efficiently inhibits opsonization, phagocytosis and killing
CC       of S.aureus by human neutrophils. Acts by binding and stabilizing human
CC       C3 convertases (C4b2a and C3bBb), leading to their inactivation. The
CC       convertases are no longer able to cleave complement C3, therefore
CC       preventing further C3b deposition on the bacterial surface and
CC       phagocytosis of the bacterium. Also prevents C5a-induced neutrophil
CC       responses. {ECO:0000269|PubMed:16882032}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16086019,
CC       ECO:0000269|PubMed:16882032}.
CC   -!- DEVELOPMENTAL STAGE: Expressed maximally during the exponential growth
CC       phase. {ECO:0000269|PubMed:16882032}.
CC   -!- INDUCTION: Up-regulated by agr and sae loci. Down-regulated by sigma B
CC       factor. {ECO:0000269|PubMed:16882032}.
CC   -!- SIMILARITY: Belongs to the SCIN family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD31213.1; -; Genomic_DNA.
DR   RefSeq; WP_000702262.1; NZ_LS483365.1.
DR   RefSeq; YP_500655.1; NC_007795.1.
DR   AlphaFoldDB; Q2FWV6; -.
DR   BMRB; Q2FWV6; -.
DR   SMR; Q2FWV6; -.
DR   STRING; 1280.SAXN108_2045; -.
DR   EnsemblBacteria; ABD31213; ABD31213; SAOUHSC_02167.
DR   GeneID; 3921862; -.
DR   GeneID; 66840169; -.
DR   KEGG; sao:SAOUHSC_02167; -.
DR   PATRIC; fig|93061.5.peg.1966; -.
DR   eggNOG; ENOG50305IG; Bacteria.
DR   HOGENOM; CLU_166895_0_0_9; -.
DR   OMA; LARTMYP; -.
DR   PRO; PR:Q2FWV6; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR021612; SCIN.
DR   Pfam; PF11546; CompInhib_SCIN; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..116
FT                   /note="Staphylococcal complement inhibitor"
FT                   /id="PRO_0000319874"
FT   REGION          62..79
FT                   /note="Essential for activity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   116 AA;  13052 MW;  6C30E48187D31719 CRC64;
     MKIRKSILAG TLAIVLASPL VTNLDKNEAQ ASTSLPTSNE YQNEKLANEL KSLLDELNVN
     ELATGSLNTY YKRTIKISGL KAMYALKSKD FKKMSEAKYQ LQKIYNEIDE ALKSKY