ID   SCIN_STAAS              Reviewed;         116 AA.
AC   Q6G7Z2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Staphylococcal complement inhibitor;
DE            Short=SCIN;
DE   Flags: Precursor;
GN   Name=scn; OrderedLocusNames=SAS1866;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Involved in countering the first line of host defense
CC       mechanisms. Efficiently inhibits opsonization, phagocytosis and killing
CC       of S.aureus by human neutrophils. Acts by binding and stabilizing human
CC       C3 convertases (C4b2a and C3bBb), leading to their inactivation. The
CC       convertases are no longer able to cleave complement C3, therefore
CC       preventing further C3b deposition on the bacterial surface and
CC       phagocytosis of the bacterium. Also prevents C5a-induced neutrophil
CC       responses (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCIN family. {ECO:0000305}.
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DR   EMBL; BX571857; CAG43672.1; -; Genomic_DNA.
DR   RefSeq; WP_000702263.1; NC_002953.3.
DR   AlphaFoldDB; Q6G7Z2; -.
DR   BMRB; Q6G7Z2; -.
DR   SMR; Q6G7Z2; -.
DR   KEGG; sas:SAS1866; -.
DR   HOGENOM; CLU_166895_0_0_9; -.
DR   OMA; LARTMYP; -.
DR   PRO; PR:Q6G7Z2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR021612; SCIN.
DR   Pfam; PF11546; CompInhib_SCIN; 1.
PE   3: Inferred from homology;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..116
FT                   /note="Staphylococcal complement inhibitor"
FT                   /id="PRO_0000319869"
FT   REGION          62..79
FT                   /note="Essential for activity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   116 AA;  13067 MW;  6C30E481973D19E9 CRC64;
     MKIRKSILAG TLAIVLASPL VTNLDKNEAQ ASTSLPTSNE YQNEKLANEL KSLLDELNVN
     ELATGSLNTY YKRTIKISGQ KAMYALKSKD FKKMSEAKYQ LQKIYNEIDE ALKSKY