ID   SCKI_MESMA              Reviewed;          55 AA.
AC   Q7Z0H4;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Neurotoxin BmP08;
DE   AltName: Full=Short-chain peptide BmKX;
DE   Flags: Precursor;
OS   Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34649;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], PARTIAL PROTEIN SEQUENCE,
RP   SYNTHESIS, STRUCTURE BY NMR OF 24-54, AND DISULFIDE BONDS.
RC   TISSUE=Venom;
RX   PubMed=15683869; DOI=10.1016/j.toxicon.2004.11.014;
RA   Wang C.-G., Cai Z., Lu W., Wu J., Xu Y., Shi Y., Chi C.-W.;
RT   "A novel short-chain peptide BmKX from the Chinese scorpion Buthus martensi
RT   karsch, sequencing, gene cloning and structure determination.";
RL   Toxicon 45:309-319(2005).
RN   [2]
RP   PROTEIN SEQUENCE OF 24-54, MASS SPECTROMETRY, STRUCTURE BY NMR OF 24-54,
RP   AND DISULFIDE BONDS.
RC   TISSUE=Venom;
RX   PubMed=15823559; DOI=10.1016/j.bbrc.2005.03.084;
RA   Chen X., Li Y., Tong X., Zhang N., Wu G., Zhang Q., Wu H.;
RT   "Solution structure of BmP08, a novel short-chain scorpion toxin from
RT   Buthus martensi Karsch.";
RL   Biochem. Biophys. Res. Commun. 330:1116-1126(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=3326; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:15823559};
CC   -!- MISCELLANEOUS: Does not show any effect on Na(+), Ca(2+) currents, nor
CC       on voltage-gated and calcium-activated potassium channels.
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DR   EMBL; AY125328; AAM91031.1; -; mRNA.
DR   EMBL; AY147404; AAN39841.1; -; Genomic_DNA.
DR   PDB; 1RJI; NMR; -; A=24-54.
DR   PDB; 1WT8; NMR; -; A=24-54.
DR   PDBsum; 1RJI; -.
DR   PDBsum; 1WT8; -.
DR   AlphaFoldDB; Q7Z0H4; -.
DR   SMR; Q7Z0H4; -.
DR   EvolutionaryTrace; Q7Z0H4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:15823559"
FT   CHAIN           24..54
FT                   /note="Neurotoxin BmP08"
FT                   /id="PRO_0000035338"
FT   DISULFID        30..45
FT   DISULFID        36..50
FT   DISULFID        39..53
FT   STRAND          29..32
FT                   /evidence="ECO:0007829|PDB:1WT8"
FT   HELIX           33..36
FT                   /evidence="ECO:0007829|PDB:1RJI"
FT   TURN            37..39
FT                   /evidence="ECO:0007829|PDB:1RJI"
FT   STRAND          47..51
FT                   /evidence="ECO:0007829|PDB:1RJI"
SQ   SEQUENCE   55 AA;  6145 MW;  8B30D90904D6A39C CRC64;
     MKIFFAVLVI LVLFSMLIWT AYGTPYPVNC KTDRDCVMCG LGISCKNGYC QGCTR