SCK_HOTTA
ID SCK_HOTTA Reviewed; 45 AA.
AC O96669;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=Putative potassium channel blocker;
DE Flags: Fragment;
OS Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX NCBI_TaxID=34647;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Jeyaseelan K., Armugam A., Shrestha R., Kini R.M., Strong P.N.,
RA Gopalakrishnakone P.;
RT "Molecular cloning of potassium channel blocking toxin gene from Indian red
RT scorpion, Mesobuthus tamulus.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits potassium channels.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
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DR EMBL; AF102776; AAC72985.1; -; Genomic_DNA.
DR AlphaFoldDB; O96669; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW Secreted; Toxin.
FT CHAIN <1..45
FT /note="Putative potassium channel blocker"
FT /id="PRO_0000066864"
FT NON_TER 1
SQ SEQUENCE 45 AA; 5241 MW; 2433AC8FB19931CB CRC64;
CQNECCGISS LRERNYCANL VCINCFCQGR TYKICRCFFS IHAIR