SCL18_ARATH
ID SCL18_ARATH Reviewed; 445 AA.
AC Q9ZWC5; A5YYE7;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Scarecrow-like protein 18;
DE Short=AtSCL18;
DE AltName: Full=GRAS family protein 7;
DE Short=AtGRAS-7;
DE AltName: Full=Protein LATERAL SUPPRESSOR;
GN Name=SCL18; Synonyms=LAS; OrderedLocusNames=At1g55580; ORFNames=F20N2.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=12730136; DOI=10.1101/gad.260703;
RA Greb T., Clarenz O., Schaefer E., Mueller D., Herrero R., Schmitz G.,
RA Theres K.;
RT "Molecular analysis of the LATERAL SUPPRESSOR gene in Arabidopsis reveals a
RT conserved control mechanism for axillary meristem formation.";
RL Genes Dev. 17:1175-1187(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-277.
RC STRAIN=cv. Ag-0, cv. An-1, cv. Bay-0, cv. Br-0, cv. C24, cv. Ct-0,
RC cv. Cvi-0, cv. Edi-0, cv. Ei-2, cv. Ga-0, cv. Gy-0, cv. Kas-2, cv. Ll-0,
RC cv. Mrk-0, cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Sorbo,
RC cv. Wa-1, cv. Wassilewskija, cv. Wei-0, and cv. Wt-5;
RX PubMed=18305205; DOI=10.1104/pp.108.116582;
RA Ehrenreich I.M., Purugganan M.D.;
RT "Sequence variation of microRNAs and their binding sites in Arabidopsis.";
RL Plant Physiol. 146:1974-1982(2008).
RN [6]
RP GENE FAMILY.
RX PubMed=15316287; DOI=10.1023/b:plan.0000038256.89809.57;
RA Tian C., Wan P., Sun S., Li J., Chen M.;
RT "Genome-wide analysis of the GRAS gene family in rice and Arabidopsis.";
RL Plant Mol. Biol. 54:519-532(2004).
RN [7]
RP GENE FAMILY, AND TISSUE SPECIFICITY.
RX PubMed=18500650; DOI=10.1007/s11103-008-9345-1;
RA Lee M.-H., Kim B., Song S.-K., Heo J.-O., Yu N.-I., Lee S.A., Kim M.,
RA Kim D.G., Sohn S.O., Lim C.E., Chang K.S., Lee M.M., Lim J.;
RT "Large-scale analysis of the GRAS gene family in Arabidopsis thaliana.";
RL Plant Mol. Biol. 67:659-670(2008).
CC -!- FUNCTION: Probable transcription factor required for axillary (lateral)
CC shoot meristem formation during vegetative development. Seems to act
CC upstream of REVOLUTA. {ECO:0000269|PubMed:12730136}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots and flowers.
CC {ECO:0000269|PubMed:18500650}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the axils of leaf primordia and
CC leaves from P1 to P20/22. In the axil of P1, expressed in 3 to 5 cell
CC layers including the L1 to L3 layers of the shoot apical meristem
CC (SAM). Then, extends from 1 or 2 cell layers in the adaxial-abaxial
CC dimension. From P5 to P22, expression is restricted to a 1 to 2 cell-
CC layer domain located within primordium. In the axils of older leaf
CC primordia, expression decreases until it is no longer detectable in the
CC axils of primordia older than P20/P22. {ECO:0000269|PubMed:12730136}.
CC -!- DISRUPTION PHENOTYPE: Plants fail to initiate axillary meristems and do
CC not form lateral shoots during vegetative development.
CC {ECO:0000269|PubMed:12730136}.
CC -!- SIMILARITY: Belongs to the GRAS family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY196482; AAP20048.1; -; mRNA.
DR EMBL; AC002328; AAF79493.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33268.1; -; Genomic_DNA.
DR EMBL; BT026519; ABH04626.1; -; mRNA.
DR EMBL; EF598379; ABR08911.1; -; Genomic_DNA.
DR EMBL; EF598380; ABR08912.1; -; Genomic_DNA.
DR EMBL; EF598381; ABR08913.1; -; Genomic_DNA.
DR EMBL; EF598382; ABR08914.1; -; Genomic_DNA.
DR EMBL; EF598383; ABR08915.1; -; Genomic_DNA.
DR EMBL; EF598384; ABR08916.1; -; Genomic_DNA.
DR EMBL; EF598385; ABR08917.1; -; Genomic_DNA.
DR EMBL; EF598386; ABR08918.1; -; Genomic_DNA.
DR EMBL; EF598387; ABR08919.1; -; Genomic_DNA.
DR EMBL; EF598388; ABR08920.1; -; Genomic_DNA.
DR EMBL; EF598389; ABR08921.1; -; Genomic_DNA.
DR EMBL; EF598390; ABR08922.1; -; Genomic_DNA.
DR EMBL; EF598391; ABR08923.1; -; Genomic_DNA.
DR EMBL; EF598392; ABR08924.1; -; Genomic_DNA.
DR EMBL; EF598393; ABR08925.1; -; Genomic_DNA.
DR EMBL; EF598394; ABR08926.1; -; Genomic_DNA.
DR EMBL; EF598395; ABR08927.1; -; Genomic_DNA.
DR EMBL; EF598396; ABR08928.1; -; Genomic_DNA.
DR EMBL; EF598397; ABR08929.1; -; Genomic_DNA.
DR EMBL; EF598398; ABR08930.1; -; Genomic_DNA.
DR EMBL; EF598399; ABR08931.1; -; Genomic_DNA.
DR EMBL; EF598400; ABR08932.1; -; Genomic_DNA.
DR EMBL; EF598401; ABR08933.1; -; Genomic_DNA.
DR EMBL; EF598402; ABR08934.1; -; Genomic_DNA.
DR RefSeq; NP_175954.1; NM_104434.4.
DR AlphaFoldDB; Q9ZWC5; -.
DR SMR; Q9ZWC5; -.
DR STRING; 3702.AT1G55580.1; -.
DR PaxDb; Q9ZWC5; -.
DR PRIDE; Q9ZWC5; -.
DR ProteomicsDB; 232802; -.
DR EnsemblPlants; AT1G55580.1; AT1G55580.1; AT1G55580.
DR GeneID; 842007; -.
DR Gramene; AT1G55580.1; AT1G55580.1; AT1G55580.
DR KEGG; ath:AT1G55580; -.
DR Araport; AT1G55580; -.
DR TAIR; locus:2020487; AT1G55580.
DR eggNOG; ENOG502QTC4; Eukaryota.
DR HOGENOM; CLU_011924_0_2_1; -.
DR InParanoid; Q9ZWC5; -.
DR OMA; VSAWQPS; -.
DR OrthoDB; 1063953at2759; -.
DR PhylomeDB; Q9ZWC5; -.
DR PRO; PR:Q9ZWC5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9ZWC5; baseline and differential.
DR Genevisible; Q9ZWC5; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0090506; P:axillary shoot meristem initiation; IGI:TAIR.
DR GO; GO:0010014; P:meristem initiation; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0010223; P:secondary shoot formation; IMP:TAIR.
DR InterPro; IPR030017; Scarecrow-like_18.
DR InterPro; IPR005202; TF_GRAS.
DR PANTHER; PTHR31636; PTHR31636; 1.
DR PANTHER; PTHR31636:SF2; PTHR31636:SF2; 1.
DR Pfam; PF03514; GRAS; 1.
DR PROSITE; PS50985; GRAS; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..445
FT /note="Scarecrow-like protein 18"
FT /id="PRO_0000350859"
FT DOMAIN 32..445
FT /note="GRAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..127
FT /note="Leucine repeat I (LRI)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT REGION 146..217
FT /note="VHIID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT REGION 227..259
FT /note="Leucine repeat II (LRII)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT REGION 275..366
FT /note="PFYRE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT REGION 369..445
FT /note="SAW"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT MOTIF 179..183
FT /note="VHIID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
SQ SEQUENCE 445 AA; 50009 MW; D89C1110E877FA53 CRC64;
MLTSFKSSSS SSEDATATTT ENPPPLCIAS SSAATSASHH LRRLLFTAAN FVSQSNFTAA
QNLLSILSLN SSPHGDSTER LVHLFTKALS VRINRQQQDQ TAETVATWTT NEMTMSNSTV
FTSSVCKEQF LFRTKNNNSD FESCYYLWLN QLTPFIRFGH LTANQAILDA TETNDNGALH
ILDLDISQGL QWPPLMQALA ERSSNPSSPP PSLRITGCGR DVTGLNRTGD RLTRFADSLG
LQFQFHTLVI VEEDLAGLLL QIRLLALSAV QGETIAVNCV HFLHKIFNDD GDMIGHFLSA
IKSLNSRIVT MAEREANHGD HSFLNRFSEA VDHYMAIFDS LEATLPPNSR ERLTLEQRWF
GKEILDVVAA EETERKQRHR RFEIWEEMMK RFGFVNVPIG SFALSQAKLL LRLHYPSEGY
NLQFLNNSLF LGWQNRPLFS VSSWK
