SCL22_ARATH
ID SCL22_ARATH Reviewed; 623 AA.
AC Q9M000; B2CV30; B2CV32;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Scarecrow-like protein 22;
DE Short=AtSCL22;
DE AltName: Full=GRAS family protein 21;
DE Short=AtGRAS-21;
DE AltName: Full=SCL6-III;
GN Name=SCL22; OrderedLocusNames=At3g60630; ORFNames=T4C21.40;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 180-354, AND VARIANT THR-305.
RC STRAIN=cv. Ag-0, cv. An-1, cv. Bay-0, cv. Br-0, cv. C24, cv. Ct-0,
RC cv. Cvi-0, cv. Edi-0, cv. Ei-2, cv. Ga-0, cv. Gy-0, cv. Kas-2, cv. Ll-0,
RC cv. Mrk-0, cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Sorbo,
RC cv. Wa-1, cv. Wassilewskija, cv. Wei-0, and cv. Wt-5;
RX PubMed=18305205; DOI=10.1104/pp.108.116582;
RA Ehrenreich I.M., Purugganan M.D.;
RT "Sequence variation of microRNAs and their binding sites in Arabidopsis.";
RL Plant Physiol. 146:1974-1982(2008).
RN [5]
RP GENE FAMILY.
RX PubMed=15316287; DOI=10.1023/b:plan.0000038256.89809.57;
RA Tian C., Wan P., Sun S., Li J., Chen M.;
RT "Genome-wide analysis of the GRAS gene family in rice and Arabidopsis.";
RL Plant Mol. Biol. 54:519-532(2004).
RN [6]
RP GENE FAMILY, AND TISSUE SPECIFICITY.
RX PubMed=18500650; DOI=10.1007/s11103-008-9345-1;
RA Lee M.-H., Kim B., Song S.-K., Heo J.-O., Yu N.-I., Lee S.A., Kim M.,
RA Kim D.G., Sohn S.O., Lim C.E., Chang K.S., Lee M.M., Lim J.;
RT "Large-scale analysis of the GRAS gene family in Arabidopsis thaliana.";
RL Plant Mol. Biol. 67:659-670(2008).
CC -!- FUNCTION: Probable transcription factor involved in plant development.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q9M000; Q8GZ67: At1g68160/T22E19_21; NbExp=3; IntAct=EBI-4424954, EBI-25518084;
CC Q9M000; Q9C7G6: At1g72030/F28P5_8; NbExp=4; IntAct=EBI-4424954, EBI-4426026;
CC Q9M000; Q93WB2: At5g25280; NbExp=3; IntAct=EBI-4424954, EBI-25517212;
CC Q9M000; Q93Z18: CKL3; NbExp=3; IntAct=EBI-4424954, EBI-4442347;
CC Q9M000; Q84JH7: SIRB; NbExp=4; IntAct=EBI-4424954, EBI-4424960;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in seedlings, roots, leaves and flowers.
CC {ECO:0000269|PubMed:18500650}.
CC -!- SIMILARITY: Belongs to the GRAS family. {ECO:0000305}.
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DR EMBL; AL162295; CAB82667.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE80090.1; -; Genomic_DNA.
DR EMBL; AY064062; AAL36418.1; -; mRNA.
DR EMBL; AY096372; AAM20013.1; -; mRNA.
DR EMBL; EU550731; ACB31493.1; -; Genomic_DNA.
DR EMBL; EU550732; ACB31494.1; -; Genomic_DNA.
DR EMBL; EU550733; ACB31495.1; -; Genomic_DNA.
DR EMBL; EU550734; ACB31496.1; -; Genomic_DNA.
DR EMBL; EU550735; ACB31497.1; -; Genomic_DNA.
DR EMBL; EU550736; ACB31498.1; -; Genomic_DNA.
DR EMBL; EU550737; ACB31499.1; -; Genomic_DNA.
DR EMBL; EU550738; ACB31500.1; -; Genomic_DNA.
DR EMBL; EU550739; ACB31501.1; -; Genomic_DNA.
DR EMBL; EU550740; ACB31502.1; -; Genomic_DNA.
DR EMBL; EU550741; ACB31503.1; -; Genomic_DNA.
DR EMBL; EU550742; ACB31504.1; -; Genomic_DNA.
DR EMBL; EU550743; ACB31505.1; -; Genomic_DNA.
DR EMBL; EU550744; ACB31506.1; -; Genomic_DNA.
DR EMBL; EU550745; ACB31507.1; -; Genomic_DNA.
DR EMBL; EU550746; ACB31508.1; -; Genomic_DNA.
DR EMBL; EU550747; ACB31509.1; -; Genomic_DNA.
DR EMBL; EU550748; ACB31510.1; -; Genomic_DNA.
DR EMBL; EU550749; ACB31511.1; -; Genomic_DNA.
DR EMBL; EU550750; ACB31512.1; -; Genomic_DNA.
DR EMBL; EU550752; ACB31514.1; -; Genomic_DNA.
DR EMBL; EU550754; ACB31516.1; -; Genomic_DNA.
DR EMBL; EU550751; ACB31513.1; -; Genomic_DNA.
DR EMBL; EU550753; ACB31515.1; -; Genomic_DNA.
DR PIR; T47874; T47874.
DR RefSeq; NP_191622.1; NM_115927.5.
DR AlphaFoldDB; Q9M000; -.
DR SMR; Q9M000; -.
DR BioGRID; 10548; 10.
DR IntAct; Q9M000; 7.
DR STRING; 3702.AT3G60630.1; -.
DR PaxDb; Q9M000; -.
DR PRIDE; Q9M000; -.
DR ProteomicsDB; 232805; -.
DR EnsemblPlants; AT3G60630.1; AT3G60630.1; AT3G60630.
DR GeneID; 825234; -.
DR Gramene; AT3G60630.1; AT3G60630.1; AT3G60630.
DR KEGG; ath:AT3G60630; -.
DR Araport; AT3G60630; -.
DR TAIR; locus:2101801; AT3G60630.
DR eggNOG; ENOG502QQQC; Eukaryota.
DR HOGENOM; CLU_013139_1_0_1; -.
DR InParanoid; Q9M000; -.
DR OMA; YRWMERS; -.
DR OrthoDB; 420029at2759; -.
DR PhylomeDB; Q9M000; -.
DR PRO; PR:Q9M000; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M000; baseline and differential.
DR Genevisible; Q9M000; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IMP:TAIR.
DR GO; GO:0051301; P:cell division; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0048768; P:root hair cell tip growth; IMP:TAIR.
DR InterPro; IPR005202; TF_GRAS.
DR PANTHER; PTHR31636; PTHR31636; 1.
DR Pfam; PF03514; GRAS; 1.
DR PROSITE; PS50985; GRAS; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..623
FT /note="Scarecrow-like protein 22"
FT /id="PRO_0000350861"
FT DOMAIN 235..622
FT /note="GRAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT REGION 62..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..311
FT /note="Leucine repeat I (LRI)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT REGION 330..398
FT /note="VHIID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT REGION 413..448
FT /note="Leucine repeat II (LRII)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT REGION 458..545
FT /note="PFYRE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT REGION 548..622
FT /note="SAW"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT MOTIF 361..365
FT /note="VHIID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT COMPBIAS 62..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 305
FT /note="S -> T (in strain: cv. cv. Ag-0, cv. Bay-0, cv. C24,
FT cv. Ct-0, cv. Cvi-0, cv. Kas-2, cv. Mrk-0, cv. Ms-0, cv.
FT Mt-0, cv. Nok-3, cv. Oy-0, cv. Sorbo, cv. Wa-1, cv. Wei-0
FT and cv. Wt-5)"
FT /evidence="ECO:0000269|PubMed:18305205"
SQ SEQUENCE 623 AA; 68090 MW; C4129E04F46AB336 CRC64;
MPLPFEQFQG KGVLGFLDSS SSPGYKIWAN PEKLHGRVEE DLCFVVNNGG FSEPTSVLDS
VRSPSPFVSS STTTLSSSHG GPSGGGAAAA TFSGADGKCD QMGFEDLDGV LSGGSPGQEQ
SIFRLIMAGD VVDPGSEFVG FDIGSGSDPV IDNPNPLFGY GFPFQNAPEE EKFQISINPN
PGFFSDPPSS PPAKRLNSGQ PGSQHLQWVF PFSDPGHESH DPFLTPPKIA GEDQNDQDQS
AVIIDQLFSA AAELTTNGGD NNPVLAQGIL ARLNHNLNNN NDDTNNNPKP PFHRAASYIT
EALHSLLQDS SLSPPSLSPP QNLIFRIAAY RAFSETSPFL QFVNFTANQT ILESFEGFDR
IHIVDFDIGY GGQWASLIQE LAGKRNRSSS APSLKITAFA SPSTVSDEFE LRFTEENLRS
FAGETGVSFE IELLNMEILL NPTYWPLSLF RSSEKEAIAV NLPISSMVSG YLPLILRFLK
QISPNVVVCS DRSCDRNNDA PFPNGVINAL QYYTSLLESL DSGNLNNAEA ATSIERFCVQ
PSIQKLLTNR YRWMERSPPW RSLFGQCGFT PVTLSQTAET QAEYLLQRNP MRGFHLEKRQ
SSSPSLVLCW QRKELVTVSA WKC
