SCM2A_DANRE
ID SCM2A_DANRE Reviewed; 469 AA.
AC Q6NYZ6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Calcium-binding mitochondrial carrier protein SCaMC-2-A;
DE AltName: Full=Small calcium-binding mitochondrial carrier protein 2-A;
DE AltName: Full=Solute carrier family 25 member 25-A;
GN Name=slc25a25a; Synonyms=scamc2a, slc25a25; ORFNames=zgc:77454;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Calcium-dependent mitochondrial solute carrier.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; BC066404; AAH66404.1; -; mRNA.
DR RefSeq; NP_998422.1; NM_213257.1.
DR AlphaFoldDB; Q6NYZ6; -.
DR SMR; Q6NYZ6; -.
DR STRING; 7955.ENSDARP00000008863; -.
DR PaxDb; Q6NYZ6; -.
DR Ensembl; ENSDART00000027214; ENSDARP00000008863; ENSDARG00000010572.
DR GeneID; 406541; -.
DR KEGG; dre:406541; -.
DR CTD; 406541; -.
DR ZFIN; ZDB-GENE-040426-2396; slc25a25a.
DR eggNOG; KOG0036; Eukaryota.
DR GeneTree; ENSGT00940000157207; -.
DR HOGENOM; CLU_015166_2_0_1; -.
DR InParanoid; Q6NYZ6; -.
DR OMA; SAIKFMC; -.
DR OrthoDB; 442523at2759; -.
DR PhylomeDB; Q6NYZ6; -.
DR TreeFam; TF313492; -.
DR PRO; PR:Q6NYZ6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000010572; Expressed in cleaving embryo and 35 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005347; F:ATP transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002167; Graves_DC.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00928; GRAVESDC.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Calcium; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..469
FT /note="Calcium-binding mitochondrial carrier protein SCaMC-
FT 2-A"
FT /id="PRO_0000317605"
FT TOPO_DOM 1..189
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..207
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..244
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..264
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..287
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..301
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..337
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..357
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 358..380
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..398
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 399..437
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 438..457
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 458..469
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT DOMAIN 47..80
FT /note="EF-hand 1"
FT /evidence="ECO:0000305"
FT DOMAIN 78..113
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 114..149
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REPEAT 184..270
FT /note="Solcar 1"
FT REPEAT 278..363
FT /note="Solcar 2"
FT REPEAT 375..463
FT /note="Solcar 3"
FT BINDING 64
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000305"
FT BINDING 66
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000305"
FT BINDING 71
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000305"
SQ SEQUENCE 469 AA; 52458 MW; 7F583A75FA61B1EE CRC64;
MLCLCLYVPV HNSDQIEVEY FESNGLPSEL KSLKSLSVLL PSQEFSTYRR WRKKSLKTEE
KEHDGQLDFE EFVHYLQDHE KDLKLVFKSM DRKIAGQVNA NDIVNSLRDL GVHISLKQAE
KVLKSMDKNG TMTIDWNEWK KYPTLQPAEN IPEIILYWKH STIFDVGESL MVPDEFTVEE
HLTGMWWRHL VSGGGAGAVS RTCTAPLDRL KVLMQVHGCQ GKSMCLMSGL TQMIKEGGVR
SLWRGNGINV IKIAPETALK FMAYEQIKRV MGSSQETLGI SERFVAGSLA GVIAQSTIYP
MEVLKTRLAL RKTGQYKGIS DCAKHILKTE GMSAFYKGYV PNMLGIIPYA GIDLAVYETL
KNTWLQRYGT ENADPGVFVL LACGTVSSTC GQLASYPLAL IRTRMQAQAS VEGSSQVSMT
GLFKQIMKTE GPTGLYRGLT PNFLKVIPAV SISYVVYEHI KSTLGVRSR
