SCM2B_DANRE
ID SCM2B_DANRE Reviewed; 469 AA.
AC A2CEQ0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Calcium-binding mitochondrial carrier protein SCaMC-2-B;
DE AltName: Full=Small calcium-binding mitochondrial carrier protein 2-B;
DE AltName: Full=Solute carrier family 25 member 25-B;
GN Name=slc25a25b; Synonyms=scamc2b; ORFNames=si:dkey-7o20.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: Calcium-dependent mitochondrial solute carrier.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; CR387979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR749745; CAM16394.1; -; Genomic_DNA.
DR RefSeq; NP_001153492.1; NM_001160020.1.
DR AlphaFoldDB; A2CEQ0; -.
DR SMR; A2CEQ0; -.
DR STRING; 7955.ENSDARP00000088935; -.
DR PaxDb; A2CEQ0; -.
DR PeptideAtlas; A2CEQ0; -.
DR Ensembl; ENSDART00000043010; ENSDARP00000043009; ENSDARG00000035468.
DR GeneID; 569227; -.
DR KEGG; dre:569227; -.
DR CTD; 569227; -.
DR ZFIN; ZDB-GENE-060526-340; slc25a25b.
DR eggNOG; KOG0036; Eukaryota.
DR GeneTree; ENSGT00940000157207; -.
DR HOGENOM; CLU_015166_2_0_1; -.
DR InParanoid; A2CEQ0; -.
DR OMA; DIWMQEG; -.
DR OrthoDB; 442523at2759; -.
DR PhylomeDB; A2CEQ0; -.
DR PRO; PR:A2CEQ0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000035468; Expressed in retina and 21 other tissues.
DR ExpressionAtlas; A2CEQ0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005347; F:ATP transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0060972; P:left/right pattern formation; IMP:ZFIN.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002167; Graves_DC.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00928; GRAVESDC.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Calcium; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..469
FT /note="Calcium-binding mitochondrial carrier protein SCaMC-
FT 2-B"
FT /id="PRO_0000317606"
FT TOPO_DOM 1..189
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..207
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..244
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..264
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..287
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..301
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..337
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..357
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 358..380
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..398
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 399..437
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 438..457
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 458..469
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT DOMAIN 47..80
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 78..113
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 114..149
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REPEAT 184..270
FT /note="Solcar 1"
FT REPEAT 278..363
FT /note="Solcar 2"
FT REPEAT 375..463
FT /note="Solcar 3"
FT BINDING 60
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000305"
FT BINDING 62
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000305"
FT BINDING 64
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000305"
FT BINDING 66
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000305"
FT BINDING 71
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000305"
SQ SEQUENCE 469 AA; 52712 MW; 37BCF177C9BA2B0E CRC64;
MLCLCLYVPV HISERTEFEY FESESLPVQL KSLFKLSLFL PSQEFDSYRK WRKKVVKAGD
KDLDGQLDFE EFVHYLRDHE KKLRLVFKSL DKKNDGHIDS QEIMQSLRDL GVHISEEQAE
KILKSMDKNG TMTIDWNEWR DYHLLHPAEN IPEIILYWKH STIFDVGESM LVPDEFTAEE
KNTGMWWRHL VAGGGAGAVS RTCTAPLDRL KVLMQVHATR SNSMGIAGGF TQMIREGGLR
SLWRGNGINV LKIAPESAIK FMAYEQIKRL IGSNQETLGI LERLVSGSLA GAIAQSSIYP
MEVLKTRLAL GRTGQYSGIA DCAKHIFKKE GMTAFYKGYI PNMLGIIPYA GIDLAVYETL
KNSWLQRFAT DSADPGVFVL LACGTMSSTC GQLASYPLAL VRTRMQAQAS QEGSPQMTMS
GLFRHIVRTE GAIGLYRGLA PNFMKVIPAV SISYVVYENL KITLGVQSR
