ID   SCM3_SCHPO              Reviewed;         336 AA.
AC   Q9HDY7;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=CENP-A histone chaperone scm3 {ECO:0000312|PomBase:SPAPB1A10.02};
GN   Name=scm3 {ECO:0000312|PomBase:SPAPB1A10.02}; ORFNames=SPAPB1A10.02;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Centromeric protein that plays a central role in the
CC       incorporation and maintenance of histone H3-like variant CENPA at
CC       centromeres. {ECO:0000250|UniProtKB:Q8NCD3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
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DR   EMBL; CU329670; CAC21475.1; -; Genomic_DNA.
DR   RefSeq; NP_593516.1; NM_001018950.2.
DR   AlphaFoldDB; Q9HDY7; -.
DR   BioGRID; 279869; 18.
DR   STRING; 4896.SPAPB1A10.02.1; -.
DR   iPTMnet; Q9HDY7; -.
DR   PaxDb; Q9HDY7; -.
DR   PRIDE; Q9HDY7; -.
DR   EnsemblFungi; SPAPB1A10.02.1; SPAPB1A10.02.1:pep; SPAPB1A10.02.
DR   GeneID; 2543449; -.
DR   KEGG; spo:SPAPB1A10.02; -.
DR   PomBase; SPAPB1A10.02; -.
DR   VEuPathDB; FungiDB:SPAPB1A10.02; -.
DR   eggNOG; ENOG502SCHT; Eukaryota.
DR   HOGENOM; CLU_740003_0_0_1; -.
DR   InParanoid; Q9HDY7; -.
DR   OMA; KNKNDVW; -.
DR   PRO; PR:Q9HDY7; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0034506; C:chromosome, centromeric core domain; IDA:PomBase.
DR   GO; GO:0000775; C:chromosome, centromeric region; IDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0042393; F:histone binding; IPI:PomBase.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0034080; P:CENP-A containing chromatin assembly; IMP:PomBase.
DR   GO; GO:0051382; P:kinetochore assembly; IC:PomBase.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR018465; Scm3/HJURP.
DR   Pfam; PF10384; Scm3; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..336
FT                   /note="CENP-A histone chaperone scm3"
FT                   /id="PRO_0000350767"
FT   REGION          243..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   336 AA;  37694 MW;  6770C5C0AFEA4B5A CRC64;
     MCNRQPKAVD LPPNYSCPHL LSFQSVEFNT NPTACDDVFC KRIESEKKYN DFLESLFKKY
     GRDTSDIADE VDLATGEIIV NNGHLEALKT KDDIWDPTFN NLEISASNGY EKKLDSSIGN
     PGEKAVSPVH IEDFQSPQIY KFKNLSLRDE MVSDCVFADE VPLASLFVEN VCNETIPSQS
     CVRLKINDKT RKVDASALEK KSCLLPNSSG TLTDQRGLDT IKHKSIEQNE ILHVISDTLS
     SPRRRNPLLS SPKTPLRRSF SKSKVRNSNS TKRRNFISLI SMISPRPNLS THHFNLGFQP
     LSQQTSFSGS STQNPHSSST CKKAFCFQCI SESKKC