SCM4_YEAST
ID SCM4_YEAST Reviewed; 187 AA.
AC P32564; D6VUI6; Q45U35;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Protein SCM4;
DE AltName: Full=Suppressor of CDC4 mutation 4;
GN Name=SCM4; OrderedLocusNames=YGR049W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1465103; DOI=10.1007/bf00279372;
RA Smith S.A., Kumar P., Johnston I., Rosamond J.;
RT "SCM4, a gene that suppresses mutant cdc4 function in budding yeast.";
RL Mol. Gen. Genet. 235:285-291(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SK1;
RX PubMed=16273108; DOI=10.1038/ng1674;
RA Deutschbauer A.M., Davis R.W.;
RT "Quantitative trait loci mapped to single-nucleotide resolution in yeast.";
RL Nat. Genet. 37:1333-1340(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 3210 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the ATG33 family. {ECO:0000305}.
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DR EMBL; X69566; CAA49291.1; -; Genomic_DNA.
DR EMBL; DQ115391; AAZ22464.1; -; Genomic_DNA.
DR EMBL; Z72834; CAA97049.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08147.1; -; Genomic_DNA.
DR PIR; S30093; S30093.
DR RefSeq; NP_011563.1; NM_001181178.1.
DR AlphaFoldDB; P32564; -.
DR BioGRID; 33296; 59.
DR DIP; DIP-1870N; -.
DR IntAct; P32564; 3.
DR MINT; P32564; -.
DR STRING; 4932.YGR049W; -.
DR iPTMnet; P32564; -.
DR MaxQB; P32564; -.
DR PaxDb; P32564; -.
DR PRIDE; P32564; -.
DR DNASU; 852940; -.
DR EnsemblFungi; YGR049W_mRNA; YGR049W; YGR049W.
DR GeneID; 852940; -.
DR KEGG; sce:YGR049W; -.
DR SGD; S000003281; SCM4.
DR VEuPathDB; FungiDB:YGR049W; -.
DR eggNOG; ENOG502S9YE; Eukaryota.
DR GeneTree; ENSGT00940000176491; -.
DR HOGENOM; CLU_105986_0_0_1; -.
DR InParanoid; P32564; -.
DR OMA; HLACVIG; -.
DR BioCyc; YEAST:G3O-30767-MON; -.
DR PRO; PR:P32564; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P32564; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; HDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..187
FT /note="Protein SCM4"
FT /id="PRO_0000097626"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 114..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 187 AA; 20118 MW; 6DE7C5C791B13568 CRC64;
MQVSPAIVKG IAVSSLGLYA GILTSSTVIS ITTPINVLTQ HLKNVLCTLG CWSTVLGGLA
TGAFGLSYYL AAPGERPNYL LCGLGVAPLS AAYLYLVSLF NHKLAPKCTR DQNDLEKQKD
EKLPQHHPEV KDGEAACPFS KMNNAKTLKP ESERSVKCHS YMSLHMSIVT GITIFTFGKC
ILDGFKA
