SCM5A_XENLA
ID SCM5A_XENLA Reviewed; 235 AA.
AC Q6GPA8;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Secretory carrier-associated membrane protein 5A;
DE Short=Secretory carrier membrane protein 5 A;
GN Name=scamp5-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the calcium-dependent exocytosis of signal
CC sequence-containing cytokines. Probably acts in cooperation with the
CC SNARE machinery (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi
CC network membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Recycling endosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle,
CC synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Mainly localizes in Golgi apparatus membrane. Upon
CC calcium-triggered exocytosis, it translocates to the cell membrane.
CC Highly enriched in synaptic vesicles (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SCAMP family. SCAMP5 subfamily.
CC {ECO:0000305}.
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DR EMBL; BC073233; AAH73233.1; -; mRNA.
DR RefSeq; NP_001085710.1; NM_001092241.1.
DR AlphaFoldDB; Q6GPA8; -.
DR SMR; Q6GPA8; -.
DR MaxQB; Q6GPA8; -.
DR DNASU; 444136; -.
DR GeneID; 444136; -.
DR KEGG; xla:444136; -.
DR CTD; 444136; -.
DR Xenbase; XB-GENE-5960142; scamp5.2.S.
DR OMA; KAQQEWT; -.
DR OrthoDB; 995882at2759; -.
DR Proteomes; UP000186698; Chromosome 3S.
DR Bgee; 444136; Expressed in brain and 17 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; ISS:UniProtKB.
DR GO; GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR007273; SCAMP.
DR PANTHER; PTHR10687; PTHR10687; 1.
DR Pfam; PF04144; SCAMP; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasmic vesicle; Endosome; Exocytosis; Golgi apparatus;
KW Membrane; Protein transport; Reference proteome; Synapse; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..235
FT /note="Secretory carrier-associated membrane protein 5A"
FT /id="PRO_0000370555"
FT TOPO_DOM 1..39
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..67
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..148
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 235 AA; 26073 MW; 6C0E358991F36808 CRC64;
MSDKPNNFPP LPRFIPLKPC FYQDFDTDIP DLHRTTAKRL YYLWMLNSIT LGVNLIGCLA
WLIGGGSATN FGLAFLWLIL FTPCSYVCWF RPIYKAFKTD SSFNFMAFFF TFTAQLVISI
IQAVGIPGWG VCGWIASISF FGTNVGSAVV MLIPTIMFTA VAVLSFVALT KVHRFYRGAG
GSLSKAQEEW TTGAWKNPHV QQAAQNAAFG ATQGAMTQNE PQYSATPNYG YSNEM