SCMC2_XENLA
ID SCMC2_XENLA Reviewed; 514 AA.
AC Q7ZYD5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Calcium-binding mitochondrial carrier protein SCaMC-2;
DE AltName: Full=Small calcium-binding mitochondrial carrier protein 2;
DE AltName: Full=Solute carrier family 25 member 25;
GN Name=slc25a25; Synonyms=scamc2;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Calcium-dependent mitochondrial solute carrier.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; BC043834; AAH43834.1; -; mRNA.
DR RefSeq; NP_001080348.1; NM_001086879.1.
DR AlphaFoldDB; Q7ZYD5; -.
DR SMR; Q7ZYD5; -.
DR DNASU; 380040; -.
DR GeneID; 380040; -.
DR KEGG; xla:380040; -.
DR CTD; 380040; -.
DR Xenbase; XB-GENE-5933262; slc25a25.L.
DR OrthoDB; 442523at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Bgee; 380040; Expressed in kidney and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002167; Graves_DC.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF13499; EF-hand_7; 2.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00928; GRAVESDC.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00054; EFh; 4.
DR SUPFAM; SSF103506; SSF103506; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 4.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Calcium; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..514
FT /note="Calcium-binding mitochondrial carrier protein SCaMC-
FT 2"
FT /id="PRO_0000317607"
FT TOPO_DOM 1..234
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..252
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 253..289
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..309
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..332
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..346
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 347..382
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..402
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 403..425
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..443
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 444..482
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 483..502
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 503..514
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT DOMAIN 56..91
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 92..122
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 123..158
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 159..194
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REPEAT 229..315
FT /note="Solcar 1"
FT REPEAT 323..408
FT /note="Solcar 2"
FT REPEAT 420..508
FT /note="Solcar 3"
FT BINDING 69
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 71
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 73
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 80
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 105
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 107
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 109
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 111
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 116
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 514 AA; 56808 MW; D8C127DD5A34F888 CRC64;
MARPRSLVSP LLSGVFCQCD TVSGAPHSHE TPASPSLAAA ALAADPCGGL LCGGPEHERR
LQILFQELDV NKDGAICIND LAVGLKRLGV HRTELELRKI VKAGDKDQDG QLDFDEFVHY
LRDHEKKLRL VFKSLDKKND GRIDAQEIMQ SLRDLGVNIS EQQAEKILKS MDKNGTMTID
WNEWRDYHLL HSAENIPEII LYWKHSTIFD VGENLLVPDE FTVEEKQTGM WWRHLVAGGG
AGAVSRTCTA PLDRLKVLMQ VHASRSNNMS ILGGFTHMIR EGGFRSLWRG NGINVIKIAP
ESAIKFMAYE QIKRIIGSNQ ETLGIHERFV AGSLAGVIAQ SSIYPMEVLK TRMALRKTGQ
YQGVLDCGKK ILLQEGLSAF YKGYVPNMLG IIPYAGIDLA VYETLKNAWL QRYATSSADP
GVFVLLACGT VSSTCGQLAS YPLALVRTRM QAEASVEGAP QMTMSKLFKH IVKTEGAFGL
YRGLAPNFMK VIPAVSISYV VYENLKLTLG VQSR
